Murotomi Kazutoshi

Affiliation and department：

Research field (3)： Laboratory animal science , Molecular biology , Pharmacology

Research keywords (1)：神経疾患、エピジェネティクス、酸化ストレス、糖尿病

Research theme for competitive and other funds (4)：

2019 - 2022 NASH発症過程における生体内一重項酸素の機能解明
2017 - 2022 非アルコール性肝障害の発症機序解明および早期診断法の確立と予防法の提案
2017 - 2020 糖尿病発症時の膵β細胞に発現するグルタミン酸受容体活性化シグナルの解明
2013 - 2015 Analysis of clock gene expression in diabetic vascular disorder with diabetes model mouse

Papers (31)：

Mayu Yasunaga, Tomoko Watanabe, Gen Yano, Kazutoshi Murotomi, Miki Hiramatsu, Motohiro Hirose, Masayuki Kakehata, Hidehiko Yashiro, Atsushi Yamazaki, Atsuo Ito. Zirconia substrate with periodic surface microstructures enhances osteogenic differentiation of rat adipose-derived stem cells. Materials Letters. 2023. 332. 133544-133544
Kazutoshi Murotomi, Aya Umeno, Mototada Shichiri, Masaki Tanito, Yasukazu Yoshida. Significance of Singlet Oxygen Molecule in Pathologies. International journal of molecular sciences. 2023. 24. 3
Kazutoshi Murotomi, Harumi Kagiwada, Kazumi Hirano, Shoko Yamamoto, Noriaki Numata, Yo Matsumoto, Hidekazu Kaneko, Masakazu Namihira. Cyclo-glycylproline attenuates hydrogen peroxide-induced cellular damage mediated by the MDM2-p53 pathway in human neural stem cells. Journal of cellular physiology. 2022
Mayu Yasunaga, Fumiko Kobayashi, Yu Sogo, Kazutoshi Murotomi, Motohiro Hirose, Yuki Hara, Masashi Yamazaki, Atsuo Ito. The enhancing effects of heparin on the biological activity of FGF-2 in heparin-FGF-2-calcium phosphate composite layers. Acta biomaterialia. 2022. 148. 345-354
Hirohisa Ogawa, Masahiko Azuma, Aya Umeno, Mayuko Shimizu, Kazutoshi Murotomi, Yasukazu Yoshida, Yasuhiko Nishioka, Koichi Tsuneyama. Singlet oxygen -derived nerve growth factor exacerbates airway hyperresponsiveness in a mouse model of asthma with mixed inflammation. Allergology international : official journal of the Japanese Society of Allergology. 2022. 71. 3. 395-404

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MISC (13)：

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Patents (5)：

Lectures and oral presentations (21)：

細胞内一重項酸素発生系の構築と定量的測定法の開発
(第42回日本分子生物学会年会 2019)
トレハロースは肥満型糖尿病モデルTSODマウスのNASH病態を軽減する
(第23回トレハロースシンポジウム 2019)
Transient cerebral ischemia induces NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density
(Neuroscience 2019 2019)
5-Hydroxy-4-phenyl-butenolideはKeap1-Nrf2シグナル伝達経路活性化を介して酸化ストレス耐性を付与する
(第71回日本酸化ストレス学会 2018)
肥満型糖尿病モデルTSODマウスのNASH初期段階における脾臓鉄レベルの解析
(第41回日本鉄バイオサイエンス学会 2017)

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