Rchr
J-GLOBAL ID:201801017455534141
Update date: Jun. 30, 2024
Mihoko Hagiwara-Nagasawa
Mihoko Hagiwara-Nagasawa
Research field (1):
Pharmacology
Research theme for competitive and other funds (2):
- 2019 - 心房細動薬物治療における有効不応期延長作用の病態薬理学的意義の解明
- 2017 - 2018 アルツハイマー病治療薬による致死性不整脈の発生機序の解明および回避戦略の検討
Papers (5):
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Ryuichi Kambayashi, Ai Goto, Mihoko Hagiwara-Nagasawa, Hiroko Izumi-Nakaseko, Makoto Shinozaki, Shinichi Kawai, Akio Matsumoto, Yoshinori Takei, Atsushi Sugiyama. Analysis of clinically-reported, memantine-induced cardiovascular adverse responses using the halothane-anesthetized dogs: Reverse translational study. Journal of pharmacological sciences. 2022. 148. 4. 343-350
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Ryuichi Kambayashi, Hiroko Izumi-Nakaseko, Ai Goto, Kazuya Tsurudome, Hironori Ohshiro, Taku Izumi, Mihoko Hagiwara-Nagasawa, Koki Chiba, Ryota Nishiyama, Satomi Oyama, et al. Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses. Frontiers in Pharmacology. 2021. 12
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萩原 美帆子, 中村 裕二, 後藤 愛, 千葉 浩輝, Lubna Nur Jaharat, 中瀬古 寛子[泉], 安東 賢太郎, 内藤 篤彦, 杉山 篤. Donepezilの心血管安全性薬理評価 ハロセン麻酔犬生体位心臓を用いて. 応用薬理. 2017. 92. 5-6. 165-165
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萩原 美帆子, 神林 隆一, 仲條 美佐子, 永澤 悦伸, 相本 恵美, 高原 章. 急性房室ブロックウサギはアドレナリンα1受容体遮断作用を有するQT延長薬の催不整脈作用を検出できる. 日本薬学会年会要旨集. 2017. 137年会. 4. 102-102
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Hagiwara Mihoko, Kambayashi Ryuichi, Takada Kazuhiro, Kusakabe Taichi, Kato Keisuke, Takahara Akira. Involvement of L-type Ca2+ channels and Na+/Ca2+ exchanger in drug-induced ventricular arrhythmias in rabbits with acute atrioventricular block. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2015. 128. 3. S173
MISC (23):
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Goto A†, Kambayashi R†, Hagiwara-Nagasawa M†, Izumi-Nakaseko H†, Takei Y†, Kawai S†, Matsumoto A†, Lurie K, Sugiyama A*†. Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs. Heart and vessels. 2022. 37. 10. in press-1815
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Hagiwara-Nagasawa M†, Kambayashi R†, Goto A†, Chiba K†, Wada T†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Lurie KG, et al. Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano-physiology and potential application. The Journal of Physiological Sciences. 2021. 71. 1. in press-17
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Goto A†, Sakamoto K, Hagiwara-Nagasawa M†, Kambayashi R†, Chiba K†, Nunoi Y†, Izumi-Nakaseko H†, Takei Y†, Matsumoto A†, Sugiyama A*†. In vivo analysis of the effects of intravenously as well as orally administered moxifloxacin on the pharmacokinetic and electrocardiographic variables along with its torsadogenic action in the chronic atrioventricular block cynomolgus monkeys. Journal of Pharmacological Sciences. 2020. 143. 4. 272-280
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中瀬古(泉)寛子, 中瀬古(泉)寛子, 藤吉正哉, 長澤(萩原)美帆子, 後藤愛, 千葉浩輝, 神林隆一, 内藤篤彦, 安東賢太郎, 諫田泰成, et al. ダサチニブは左心機能を低下するが,催不整脈作用を示さない:チロシンキナーゼ阻害薬のヒト心血管有害作用を予測する非臨床的評価方法の開発. 日本薬理学雑誌. 2020. 155. Supplement
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光井英晃, 長澤(萩原, 美帆子, 神林隆一, 布井啓雄, 千葉浩輝, 後藤愛, 中瀬古(泉, 寛子, 中瀬古(泉, et al. 完全房室ブロックサルにおける薬物性TdP発生の必要条件. 応用薬理. 2019. 96. 5-6. 133-133
more...
Books (1):
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コメディカルのための薬理学 第3版
朝倉書店 2018
Lectures and oral presentations (4):
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Effect of negative expiratory airway pressure on the systemic circulation: a new strategy to salvage patients with cardiogenic shock.
(第84回日本循環器学会学術集会, Asian Pacific Society of Cardiology Congress 2020 2020)
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Analysis of in vivo electropharmacological effects of vanoxerine.
(第93回日本薬理学会年会 2020)
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Negative expiratory airway pressure: A new strategy to salvage patients with cardiogenic shock from a vicious cycle leading to death
(第83回日本循環器学会学術集会 2019)
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Analysis of proarrhythmic potential of donepezil
(第92回日本薬理学会年会 2019)
Awards (2):
- 2018/02 - 日本安全性薬理研究会 第9回 日本安全性薬理研究会学術年会優秀研究賞 急性房室ブロックウサギはmethoxamine負荷ウサギに比べて薬物性不整脈を高感度に検出できる
- 2018/02 - 第9回 日本安全性薬理研究会学術年会 優秀研究賞
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