Rchr
J-GLOBAL ID：201801017481488310
Update date: Jan. 30, 2024
Hinoi Takao
ヒノイ タカオ | Hinoi Takao
Affiliation and department：
Job title：
特任教授
Research field (1)：
Tumor diagnostics and therapeutics
Research keywords (6)：
Surgical Oncology
, Medical Oncology
, Cancer Genetics
, Genetic Counseling
, Hereditary Cancer Syndrome
, Cancer Genome Medicine
Research theme for competitive and other funds (7)：
- 2021 - 2025 Identification of the novel driver genes in drug-resistance colorectal cancers and the development of treatment
- 2018 - 2021 Establishment of mouse models and organoids corresponding to colorectal cancer molecular subtypes and their clinical application
- 2015 - 2017 Establishment of new colon cancer animal model using CRISPR / CAS 9 genome editing system
- 2013 - 2017 Establishment of a novel mouse colon cancer disease model with different genome instability useful for subclass classification
- 2013 - 2015 Investigation of metastasis related genes based on conditinoal knock out mouse model
- 2010 - 2012 Establishment of the novel mouse model of metastatic colorectalcancer and identification of the biomarker for tissue-specific metastasis
- 2010 - 2011 Generation of intestinal epithelial cell line from induced pluripotent stem cell and establishment of colorectal cancer stem cell model
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Papers (193)：
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Takafumi Fukushima, Keisuke Goto, Tetsutaro Hayashi, Kenichiro Ikeda, Tomoya Hatayama, Ryoken Yamanaka, Kyosuke Iwane, Ryo Tasaka, Yuki Kohada, Kenshiro Takemoto, et al. Comprehensive genomic profiling testing in Japanese castration-resistant prostate cancer patients: results of a single-center retrospective cohort study. Japanese journal of clinical oncology. 2023
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Haruki Sada, Hiroyuki Sawada, Masakazu Tokunaga, Manabu Shimomura, Hiroyuki Egi, Minoru Hattori, Hiroki Ohge, Hideki Ohdan, Takao Hinoi. Clinical efficacy of Daikenchuto (DKT: TJ-100) for gastrointestinal symptoms in patients with a history of colon and rectosigmoid cancer surgery: a randomized crossover study. Surgery today. 2023. 53. 8. 873-881
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Shumpei Onishi, Fumiyuki Yamasaki, Kazuya Kuraoka, Akira Taguchi, Takeshi Takayasu, Kiwamu Akagi, Takao Hinoi. Diagnostic and therapeutic challenges of glioblastoma as an initial malignancy of constitutional mismatch repair deficiency (CMMRD): two case reports and a literature review. BMC Medical Genomics. 2023. 16. 1
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Takafumi Fukushima, Jun Teishima, Keisuke Goto, Kenshiro Takemoto, Yohei Sekino, Kohei Kobatake, Kenichiro Ikeda, Tetsutaro Hayashi, Kazuhiro Sentani, Naohide Oue, et al. Two case reports of immune checkpoint therapy on chromophobe renal cell carcinoma with sarcomatoid differentiation. International cancer conference journal. 2022. 11. 4. 286-291
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Megumi Yamaguchi, Hirotaka Tashiro, Shintaro Kuroda, Sho Okimoto, Tsuyoshi Kobayashi, Takao Hinoi, Hideki Ohdan. Downregulation of thrombomodulin contributes to ischemia-reperfusion injury in mice with steatotic liver. Hepatology research : the official journal of the Japan Society of Hepatology. 2022. 52. 9. 762-772
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MISC (27)：
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河内 雅年, 檜井 孝夫, 斎藤 保文, 新津 宏明, 佐田 春樹, 坂本 直也, 仙谷 和弘, 大上 直秀, 安井 弥, 大段 秀樹. BRAF遺伝子の下流に位置し大腸癌の増殖に関与する遺伝子Xの解析. 日本癌学会総会記事. 2020. 79回. PJ4-1
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丸山 諒太, 坂本 直也, 谷山 大樹, 常國 健太, 本間 りりの, 鵜飼 翔一, 檜井 孝夫, 大段 秀樹, 安井 弥. 大腸癌オルガノイドを用いたトリフルリジンの効用の検討. 日本癌学会総会記事. 2020. 79回. PJ11-4
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檜井 孝夫, 斉藤 保文, 新津 宏明, 河内 雅年, 佐田 春樹, 田代 裕尊, 大段 秀樹. 新規大腸上皮細胞特異的複合的遺伝子改変マウスモデルによる大腸癌ドライバー遺伝子の機能解析と新規バイオマーカーの同定. 日本消化器病学会雑誌. 2020. 117. 臨増総会. A318-A318
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Yuji Takakura, Katsunori Shinozaki, Satoshi Ikeda, Hiroyuki Egi, Yuzo Hirata, Manabu Shimomura, Takafumi Oshiro, Takao Hinoi, Daisuke Sumitani, Masahiro Nakahara, et al. Pre- versus postoperative CAPOX plus bevacizumab (CAPOX-Bev) for resectable liver metastases from colorectal cancer (CLM): A randomized phase II/III trial (HiSCO-01). JOURNAL OF CLINICAL ONCOLOGY. 2020. 38. 15
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久保田 晴菜, 首藤 毅, 清水 洋祐, 兒島 正人, 赤羽 慎太郎, 三隅 俊博, 羽田野 直人, 田澤 宏文, 清水 亘, 鈴木 崇久, et al. 区域性肝内胆管の拡張を呈した大腸癌肝転移の2例. 癌と化学療法. 2019. 46. 3. 537-539
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