Nishimura Akiyuki

ニシムラアキユキ | Nishimura Akiyuki

Affiliation and department：
Job title：特任准教授
Homepage URL (1)： http://www.nips.ac.jp/circulation/

Research field (1)： Pharmacology

Research keywords (5)：レドックス , ミトコンドリア , 心血管 , G蛋白質 , シグナル伝達

Research theme for competitive and other funds (13)：

2024 - 2027 タンパク質超硫黄化修飾に基づく代謝柔軟性制御と筋頑健性獲得機構の解明
2021 - 2026 Novel signal regulation by G protein supersulfidation and its physiological role
2020 - 2025 超硫黄フラックス解析基盤の創出による筋頑健性構築
2019 - 2022 Regulation of mitochondrial redox by sulfiredoxin in cardiac remodeling
2019 - 2022 Elucidation of mechanism underlying dysregulation of mitochondrial quality control in the failing heart and its therapeutic strategy

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Papers (52)：

Kohei Ariyoshi, Kazuhiro Nishiyama, Yuri Kato, Xinya Mi, Tomoya Ito, Yasu-Taka Azuma, Akiyuki Nishimura, Motohiro Nishida. Inhibition of Drp1-Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria-Lipid Droplet Contact. International journal of molecular sciences. 2024. 25. 10
Liuchenzi Zhou, Akiyuki Nishimura, Keitaro Umezawa, Yuri Kato, Xinya Mi, Tomoya Ito, Yasuteru Urano, Takaaki Akaike, Motohiro Nishida. Supersulfide catabolism participates in maladaptive remodeling of cardiac cells. Journal of Pharmacological Sciences. 2024
Qi Cui, Meg Shieh, Tony W Pan, Akiyuki Nishimura, Tetsuro Matsunaga, Shane S Kelly, Shi Xu, Minkyung Jung, Seiryo Ogata, Masanobu Morita, et al. 2H-Thiopyran-2-thione sulfine, a compound for converting H2S to HSOH/H2S2 and increasing intracellular sulfane sulfur levels. Nature communications. 2024. 15. 1. 2453-2453
Kazuhiro Nishiyama, Yuri Kato, Akiyuki Nishimura, Xinya Mi, Ryu Nagata, Yasuo Mori, Yasu-Taka Azuma, Motohiro Nishida. Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression. International journal of molecular sciences. 2024. 25. 4
Akiyuki Nishimura, Liuchenzi Zhou, Yuri Kato, Xinya Mi, Tomoya Ito, Yuko Ibuki, Yasunari Kanda, Motohiro Nishida. Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation. Journal of pharmacological sciences. 2024. 154. 2. 127-135

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MISC (51)：

西山和宏, 西村明幸, 加藤百合, 西田基宏. 心血管系および炎症性疾患におけるプリン受容体P2Y6受容体の病態生理意義の解明. 血管. 2023. 46. 2. 1-8
加藤百合, 冨田拓郎[沼賀], 島内司, 酒田康介, 西山和宏, 西村明幸, 岩本隆宏, 森泰生, 西田基宏. 末梢神経障害における脂質作動性TRPCチャネルの関与. 脂質生化学研究. 2023. 65. 172-173
西田基宏, 西山和宏, 加藤百合, Mi Xinya, 西村明幸. 肺高血圧症治療の新戦略 TRPC3/6タンパク質のアイソフォーム特異的な役割を標的とする創薬. 血管. 2023. 46. 1. 38-38
加藤百合, 島内司, 冨田拓郎, 酒田康介, 西山和宏, 西村明幸, 岩本隆宏, 森泰生, 西田基宏. 末梢循環障害からの血流回復におけるTRPC6の役割. 血管. 2023. 46. 1. 46-46
西村明幸, Tang Xiaokang, Hengphasat Kowit, 西山和宏, 加藤百合, 重田育照, 西田基宏. Drp1グルタチオン化は硫黄代謝異常によって引き起こされるミトコンドリア過剰分裂および心筋細胞老化を改善する. 血管. 2023. 46. 1. 47-47

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Education (3)：

2004 - 2007 Nara Institute of Science and Technology Graduate School for Biological Sciences
2002 - 2004 Nara Institute of Science and Technology Graduate School for Biological Sciences
2000 - 2002 Toyohashi University of Technology Ecological Engineering

Professional career (1)：

PhD (Nara Institute of Science and Technology)

Work history (5)：

2020/08 - 現在自然科学研究機構生理学研究所心循環シグナル研究部門特任准教授
2018/09 - 2020/07 Kyushu University Graduate School of Pharmaceutical Sciences Lecturer
2014/02 - 2018/08 National Institute for Physiological Sciences Division of Cardiocirculatory signaling Project associate professor
2010/04 - 2014/02 Cornell University College of Veterinary Medicine Postdoctoral associate
2007/04 - 2010/03 Nara Institute of Science and Technology Graduate School of Biological Sciences Postdoctoral Associate

Awards (4)：

2020/03 - 日本生理学会入澤宏・彩記念若手研究奨励賞
2018/05 - 第18回日本NO学会学術集会 Young Investigation Awards最優秀賞
2015/03 - 日本薬理学会第88回日本薬理学会年会優秀発表賞
2006/09 - 特定領域「G蛋白質シグナル」研究班特定領域「G蛋白質シグナル」研究班会議ポスター発表会最優秀発表賞

Association Membership(s) (5)：

日本NO学会 , THE PHYSIOLOGICAL SOCIETY OF JAPAN , THE JAPANESE PHARMACOLOGICAL SOCIETY , THE PHARMACEUTICAL SOCIETY OF JAPAN , Japanese Association of Cardiovascular Pharmacology

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