KOHYAMA JUN

Research field (1)： Neuroscience - general

Research theme for competitive and other funds (7)：

2019 - 2024 Unraveling mechanism of pathogenesis in CHAREGE syndrome using iPSC-derived brain organoid
2016 - 2018 Development of new technology to analyze cellular interaction between neuron and glial cells
2015 - 2018 Assessment of tumorigenic potential of human induced pluripotent stem cell-derived neural stem/progenitor cells for spinal cord injury
2014 - 2018 Crosstalk between immune system and nervous system in the pathogenesis of spinal cord injury
2008 - 2009 Site-specific epigenetic regulation in cell fate decision of neural progenitor cells

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Papers (63)：

Yusuke Saijo, Narihito Nagoshi, Momotaro Kawai, Takahiro Kitagawa, Yu Suematsu, Masahiro Ozaki, Munehisa Shinozaki, Jun Kohyama, Shinsuke Shibata, Kosei Takeuchi, et al. Human-induced pluripotent stem cell-derived neural stem/progenitor cell ex vivo gene therapy with synaptic organizer CPTX for spinal cord injury. Stem cell reports. 2024
Takahito Iga, Hiroshi Kobayashi, Dai Kusumoto, Tsukasa Sanosaka, Nobuyuki Fujita, Ikue Tai-Nagara, Tomofumi Ando, Tomoko Takahashi, Koichi Matsuo, Katsuto Hozumi, et al. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis. Nature Cell Biology. 2023
Miho Isoda, Tsukasa Sanosaka, Ryo Tomooka, Yo Mabuchi, Munehisa Shinozaki, Tomoko Andoh-Noda, Satoe Banno, Noriko Mizota, Ryo Yamaguchi, Hideyuki Okano, et al. Mesenchymal properties of iPSC-derived neural progenitors that generate undesired grafts after transplantation. Communications biology. 2023. 6. 1. 611-611
Zhi Zhou, Wataru Kakegawa, Koki Fujimori, Misato Sho, Rieko Shimamura, Sopak Supakul, Sho Yoshimatsu, Jun Kohyama, Michisuke Yuzaki, Hideyuki Okano. Highly efficient induction of functionally mature excitatory neurons from feeder-free human ES/iPS cells. 2023
Tsukasa Sanosaka, Hironobu Okuno, Noriko Mizota, Tomoko Andoh-Noda, Miki Sato, Ryo Tomooka, Satoe Banno, Jun Kohyama, Hideyuki Okano. Chromatin remodeler CHD7 targets active enhancer region to regulate cell type-specific gene expression in human neural crest cells. Scientific reports. 2022. 12. 1. 22648-22648

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MISC (110)：

神山淳. 精神科医に知ってもらいたい医学生物学の先端技術脳オルガノイド. 臨床精神医学. 2023. 52. 9. 1111-1113
神山淳. iPS細胞由来神経前駆細胞を用いた脊髄損傷に対する再生医療の実現. 日本医学会総会会誌. 2023. 31回. U40-3
北川剛裕, 名越慈人, 鎌田泰裕, 神山淳, 松本守雄, 岡野栄之, 中村雅也. 脊髄損傷に対するヒトiPS細胞由来神経幹/前駆細胞移植治療における移植細胞由来ニューロンの機能解明. 日本再生医療学会総会(Web). 2021. 20th
磯田美帆, 磯田美帆, 鎌田泰裕, 鎌田泰裕, 佐野坂司, 柴田玲生, 柴田玲生, 伊藤修平, 伊藤修平, 篠崎宗久, et al. ヒトiPS細胞由来グリア指向性神経幹/前駆細胞の誘導法確立とその有効性評価. 日本再生医療学会総会(Web). 2021. 20th
神山淳. 中枢神経系再生医療実現に向けたiPS細胞由来神経前駆細胞作成方法の最適化. 日本再生医療学会総会(Web). 2021. 20th

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Education (1)：

2002 - 2006 Keio University Graduate school of medicine

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