Taguchi Tomohiko

タグチトモヒコ | Taguchi Tomohiko

Affiliation and department：
Homepage URL (1)： https://www.lifesci.tohoku.ac.jp/research/teacher/detail---id-45523.html

Research field (1)： Cell biology

Research keywords (8)： signalling , endosomes , membrane traffic , innate immunity , phospholipids , organelles , Biochemistry , Cell Biology

Research theme for competitive and other funds (12)：

2024 - 2027 STINGのリソソームミクロオートファジー分解を制御する分子基盤
2019 - 2022 細胞内輸送が厳密に制御する自然免疫分子STINGの活性・不活性化の分子機構
2017 - 2021 細胞内小器官特異的脂質環境が制御するシグナル伝達とその破綻に起因する疾患の分子機構の解明
2015 - 2020 リポクオリティが制御する膜マイクロドメインの動態と機能
2017 - 2019 Functional analysis of ubiquitin E3 complex scaffold protein,Cullin-3 in breast cancer cells

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Papers (99)：

Toshiki Mori, Takahiro Niki, Yasunori Uchida, Kojiro Mukai, Yoshihiko Kuchitsu, Takuma Kishimoto, Shota Sakai, Asami Makino, Toshihide Kobayashi, Hiroyuki Arai, et al. A non-toxic equinatoxin-II reveals the dynamics and distribution of sphingomyelin in the cytosolic leaflet of the plasma membrane. Scientific reports. 2024. 14. 1. 16872-16872
Tsumugi Shoji, Ayumi Shinojima, Satoshi Kusumi, Daisuke Koga, Kojiro Mukai, Jun Nakayama, Shigeki Higashiyama, Yoshihiko Kuchitsu, Tomohiko Taguchi. A PI(3,5)P2/ESCRT-III axis terminates STING signalling by facilitating TSG101-mediated lysosomal microautophagy. 2024
Hitomi Karyu, Takahiro Niki, Yuriko Sorimachi, Shoji Hata, Shiho Shimabukuro-Demoto, Tetsuya Hirabayashi, Kojiro Mukai, Kohji Kasahara, Keiyo Takubo, Nobuhito Goda, et al. Collaboration between a cis-interacting natural killer cell receptor and membrane sphingolipid is critical for the phagocyte function. Frontiers in Immunology. 2024. 15
Yoshihiko Kuchitsu, Tomohiko Taguchi. STINGing organelle surface with acid. EMBO Reports. 2024
Haruka Kemmoku, Kanoko Takahashi, Kojiro Mukai, Toshiki Mori, Koichiro M. Hirosawa, Fumika Kiku, Yasunori Uchida, Yoshihiko Kuchitsu, Yu Nishioka, Masaaki Sawa, et al. Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol. Nature Communications. 2024. 15. 1

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MISC (83)：

Derek A. Applewhite, Needhi Bhalla, Nina Cabezas-Wallscheid, Neta Erez, Mengfeng Li, Jose M. Polo, Tomohiko Taguchi, Abdou Rachid Thiam, Xiaochen Wang. Mentoring the next generation of cell biologists. Nature Cell Biology. 2024. 26. 1. 15-18
田口友彦, 朽津芳彦. The STING inflammatory signal. 月刊臨床免疫・アレルギー科. 2023. 80. 6
高橋花乃子, 朽津芳彦, 田口友彦. LPDS及び7-デヒドロコレステロールレダクターゼ阻害剤(AY9944)同時処理によって,STING経路の活性化は抑制される. 日本生化学会大会(Web). 2023. 96th
湯本瑛亮, 朽津芳彦, 小出頌悟, 向井康治朗, 田口友彦. アラニンスキャニング変異体解析による自然免疫分子STINGの新規活性制御部位の同定. 日本生化学会大会(Web). 2023. 96th
進藤瑠璃, 朽津芳彦, 向井康治朗, 和栗聡, 田口友彦. リソソームによる内包化・分解現象の基質:STINGクラスリン被覆小胞クラスター. 日本生化学会大会(Web). 2023. 96th

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Books (19)：

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Lectures and oral presentations (55)：

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Education (5)：

1994 - 1997 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1992 - 1994 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1990 - 1992 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry
1988 - 1990 東京大学理科I類
1985 - 1988 兵庫県立神戸高等学校

Professional career (3)：

Work history (2)：

Committee career (7)：

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Association Membership(s) (4)：

JAPAN SOCIETY FOR CELL BIOLOGY , THE JAPANESE CONFERENCE ON THE BIOCHEMISTRY OF LIPIDS , THE JAPANESE BIOCHEMICAL SOCIETY , 日本免疫不全・自己炎症学会

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