Research field (2)：
Pathobiochemistry
, Molecular biology
Research keywords (3)：
Ubiquitin-like proteins
, UBA5
, UFM1
Research theme for competitive and other funds (4)：
2022 - 2025 Regulation of ER-phagy through the Ufmylation
2020 - 2022 Regulation of CYB5R3 function by Ufmylation
2018 - 2020 The mechanism of severe developmental disorders caused by abnormalities in UFM1 system
2016 - 2018 ユビキチン様分子Ufm1による生体制御
Papers (13)：
Ryosuke Ishimura*, Sota Ito* (*co-first authors), Gaoxin Mao, Satoko Komatsu-Hirota, Toshifumi Inada, Nobuo N. Noda, Masaaki Komatsu. Mechanistic insights into the roles of the UFM1 E3 ligase complex in ufmylation and ribosome-associated protein quality control. Science Advances. 2023. 9. 33
Ryosuke Ishimura, Afnan H. El-Gowily, Daisuke Noshiro, Satoko Komatsu-Hirota, Yasuko Ono, Mayumi Shindo, Tomohisa Hatta, Manabu Abe, Takefumi Uemura, Hyeon-Cheol Lee-Okada, et al. The UFM1 system regulates ER-phagy through the ufmylation of CYB5R3. Nature Communications. 2022. 13. 1. 7857-7857
Shun-suke Sakai, Atsushi Hasegawa, Ryosuke Ishimura, Naoki Tamura, Shun Kageyama, Satoko Komatsu-Hirota, Manabu Abe, Yiwei Ling, Shujiro Okuda, Manabu Funayama, et al. Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size. Molecular and Cellular Biology. 2022. 42. 1
Lauren C. Briere, Melissa A. Walker, Frances A. High, Cynthia Cooper, Cassandra A. Rogers, Christine J. Callahan, Ryosuke Ishimura, Yoshinobu Ichimura, Paul A. Caruso, Nutan Sharma, et al. A description of novel variants and review of phenotypic spectrum in UBA5-related early epileptic encephalopathy. Cold Spring Harb Mol Case Stud . 2021. 7. 3. a005827-a005827
Macarena Cabrera-Serrano, David Joseph Coote, Dimitar Azmanov, Hayley Goullee, Erik Andersen, Catriona McLean, Mark Davis, Ryosuke Ishimura, Zornitza Stark, Jean-Michel Vallat, et al. A homozygous UBA5 pathogenic variant causes a fatal congenital neuropathy. Journal of Medical Genetics. 2020. 57. 12. 835-842
