Wataru Nakajima

Affiliation and department：

Research field (1)： Tumor biology

Research theme for competitive and other funds (5)：

2023 - 2027 Clinical significance and development of new target treatment of activated mitochondrial function in acute myeloid leukemia
2023 - 2027 DNMT3A変異陽性AMLに生じるG2/M期の遺伝子発現異常とその標的治療の開発
2022 - 2025 分子標的薬耐性肺がんにおける薬剤耐性獲得機構の解明と代謝制御を利用した治療法開発
2016 - 2020 乳癌のサブタイプ別に化学療法の治療効果を決定づける因子の解析と治療予測効果の検討
2005 - 2009 Analysis of the gene transcriptional network system regulated by nuclear tumor suppressive factors

Papers (22)：

Takeru Torii, Wataru Sugimoto, Katsuhiko Itoh, Natsuki Kinoshita, Masaya Gessho, Toshiyuki Goto, Ikuno Uehara, Wataru Nakajima, Yemima Budirahardja, Daisuke Miyoshi, et al. Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments. Cell death & disease. 2023. 14. 11. 766-766
Natsuki Kinoshita, Masaya Gessho, Takeru Torii, Yukako Ashida, Minori Akamatsu, Alvin Kunyao Guo, Sunmin Lee, Tatsuya Katsuno, Wataru Nakajima, Yemima Budirahardja, et al. The iron chelator deferriferrichrysin induces paraptosis via extracellular signal-related kinase activation in cancer cells. Genes to cells : devoted to molecular & cellular mechanisms. 2023. 28. 9. 653-662
Wataru Nakajima, Kai Miyazaki, Masahiro Sakaguchi, Yumi Asano, Mariko Ishibashi, Tomoko Kurita, Hiroki Yamaguchi, Hiroyuki Takei, Nobuyuki Tanaka. Epigenetic Priming with Decitabine Augments the Therapeutic Effect of Cisplatin on Triple-Negative Breast Cancer Cells through Induction of Proapoptotic Factor NOXA. Cancers. 2022. 14. 1
Wataru Nakajima, Kai Miyazaki, Yumi Asano, Satoshi Kubota, Nobuyuki Tanaka. Krüppel-Like Factor 4 and Its Activator APTO-253 Induce NOXA-Mediated, p53-Independent Apoptosis in Triple-Negative Breast Cancer Cells. Genes. 2021. 12. 4
Yushi Hayashi, Hidenori Suzuki, Wataru Nakajima, Ikuno Uehara, Atsuko Tanimura, Toshiki Himeda, Satoshi Koike, Tatsuya Katsuno, Shin-Ichiro Kitajiri, Naoto Koyanagi, et al. Virus-infection in cochlear supporting cells induces audiosensory receptor hair cell death by TRAIL-induced necroptosis. PloS one. 2021. 16. 11. e0260443

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MISC (50)：

中嶋亘, 石野孔祐, 宮崎海, 大橋隆治, 山本林. Identification of Immune Checkpoint Inhibitor Therapeutic Resistance Factors in EGFR-mutated Non-Small Cell Lung Cancer. 日本癌学会学術総会抄録集(Web). 2023. 82nd
取井猛流, 杉本亘, 伊藤功彦, 木下菜月, 月生雅也, 後藤俊志, 上原郁野, 中嶋亘, BUDIRAHARDJA Yemima, 三好大輔, et al. Elucidation of the mechanism of nuclear actin filament formation by anti-tumor drug and its regulation. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
中嶋亘, 石野孔祐, 中道真仁, 松本優, 大橋隆治, 山本林. Elucidation of the mechanism of drug resistance acquisition in EGFR-Mutated Lung Adenocarcinoma. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
湯川廉樹, 石野孔祐, 呉壮香, 北村妙子, 河本陽子, 手塚潔, 藤井雄文, 工藤光洋, 大橋隆治, 中嶋亘. 甲状腺未分化癌細胞におけるメトホルミンによる増殖抑制とオートファジーの関係性の解析. 日本医科大学医学会雑誌. 2023. 19. 4
木下菜月, 芦田侑加子, 赤松実憲, BUDIRAHARDJA Yemima, 中嶋亘, 月生雅也, 取井猛流, 三好大輔, 戸所健彦, 石田博樹, et al. The anticancer effect of deferriferrichrysin produced by Aspergillus oryzae. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th

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Lectures and oral presentations (1)：

平成28年度丸山記念研究助成金受賞記念講演(1)
(日医大医会誌 2017)

Work history (1)：

2012/10 - 2014/09 Virginia commonwealth university Massay Cancer Center postdoctoral fellow

Awards (3)：

2016/12 - 日本分子生物学会優秀ポスター賞 BRCAness乳癌細胞株の微小管阻害薬パクリタキセルに対する抵抗性機構の解析
2016/07 - 日本医科大学丸山記念研究助成受賞金受賞
2008/09 - 日本医科大学日本医科大学優秀論文賞

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