Rchr
J-GLOBAL ID：201801018186487251   Update date: Apr. 15, 2024

Nishiyama Akihito

Nishiyama Akihito
Affiliation and department：
Niigata University

About Niigata University


Homepage URL  (1)： https://www.med-niigatauniv-bacteriol.org
Research field  (1)： Bacteriology
Research keywords  (2)： tuberculosis ,  bacteriology
Research theme for competitive and other funds  (5)：
  • 2019 - 2022 結核の発病予測向上と治療期間 短縮を目指した生物学的要因の 探索(研究分担者)
  • 2017 - 2020 細菌における天然変性蛋白質のヒストンコード機構による形質制御の証明
  • 2016 - 2019 結核菌の潜在化機構の解析と、潜在化の維持による結核制圧戦略の構築
  • 2015 - 2018 結核菌抗原による形質細胞様樹状細胞の活性化を介する新しい結核防御免疫機構の解明
  • 2008 - 2010 Panton-Valentineロイコシジンの毒素活性発現メカニズムの解明
Papers (64)：
  • Atsuki Takeishi, Amina K. Shaban, Taichi Kakihana, Hayato Takihara, Shujiro Okuda, Hidekazu Osada, Desak Nyoman Surya Suameitria Dewi, Yuriko Ozeki, Yutaka Yoshida, Akihito Nishiyama, et al. Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo. Microbiology and Immunology. 2024
  • Akihito Nishiyama, Masahiro Shimizu, Tomoyuki Narita, Noriyuki Kodera, Yuriko Ozeki, Akira Yokoyama, Kouta Mayanagi, Takehiro Yamaguchi, Mariko Hakamata, Amina Kaboso Shaban, et al. Dynamic action of an intrinsically disordered protein in DNA compaction that induces mycobacterial dormancy. Nucleic acids research. 2023
  • Yutaka Yoshida, Akihito Nishiyama, Desak Nyoman Surya Suameitria Dewi, Tomoya Yamazaki, Akira Yokoyama, Daiki Kobayashi, Hitoshi Kondo, Yuriko Ozeki, Sohkichi Matsumoto. Limited proteolysis of mycobacterial DNA-binding protein 1 with an extended, lysine-rich, intrinsically disordered region to unveil posttranslational modifications. Biochemical and Biophysical Research Communications. 2023. 681. 111-119
  • Amina K Shaban, Gebremichal Gebretsadik, Mariko Hakamata, Hayato Takihara, Erina Inouchi, Akihito Nishiyama, Yuriko Ozeki, Yoshitaka Tateishi, Yukiko Nishiuchi, Takehiro Yamaguchi, et al. Mycobacterial DNA-binding protein 1 is critical for BCG survival in stressful environments and simultaneously regulates gene expression. Scientific reports. 2023. 13. 1. 14157-14157
  • Desak Nyoman Surya Suameitria Dewi, Ni Made Mertaniasih, Soedarsono, Kimika Hagino, Tomoya Yamazaki, Yuriko Ozeki, Wayan Tunas Artama, Haruka Kobayashi, Erina Inouchi, Yutaka Yoshida, et al. Antibodies against native proteins of Mycobacterium tuberculosis can detect pulmonary tuberculosis patients. Scientific Reports. 2023
ｍore...
MISC (33)：
  • 山崎 智也, 石川 智史, 田村 敏生, 塚本 裕美子, Nyoman Desak, 吉田 豊, 尾関 百合子, 西山 晃史, 立石 善隆, 松本 壮吉. 野生型結核菌抗原を用いた抗体検出による活動性結核の診断と発症予測法の検討. 日本細菌学雑誌. 2023. 78. 1. 69-69
  • 袴田真理子, 袴田真理子, 瀧原速仁, 岩本朋忠, 岩本朋忠, 田丸亜貴, 尾関百合子, 西山晃史, 立石善隆, 菊地利明, et al. GENOME ANALYSIS OF MYCOBACTERIUM TUBERCULOSIS BEIJING STRAINS ISOLATED FROM EARLY-ONSET AND LONG TERM LATENT POST-ONSET. 結核(Web). 2021. 96. 3
  • 袴田真理子, 袴田真理子, 瀧原速仁, 尾関百合子, 西山晃史, 立石善隆, 大橋璃子, 奥田修二郎, 田井中一貴, 菊地利明, et al. Genome analysis of Beijing lineage of Mtb and monitoring mycobacterial infection by CUBIC. 日本細菌学雑誌(Web). 2021. 76. 1
  • 阿部透, 袴田真理子, 西山晃史, 立石善隆, 松本壮吉, 邊見久, 上田大次郎, 佐藤努. マイコバクテリア由来新規Z,E混成型プレニル基還元酵素の機能解析によるセスクアテルペン生合成の洞察. イソプレノイド研究会例会講演要旨集. 2021. 31st (CD-ROM)
  • 阿部透, 袴田真理子, 西山晃史, 立石善隆, 松本壮吉, 邊見久, 上田大次郎, 佐藤努. マイコバクテリア由来新規Z,E混成型プレニル基還元酵素の機能解析. 日本放線菌学会大会講演要旨集. 2021. 35th (CD-ROM)
ｍore...
Books (3)：
  • 病原微生物学 基礎と臨床
    東京化学同人 2014
  • 病原菌の今日的意味 改訂4版
    医薬ジャーナル社 2011
  • MRSA -基礎・臨床・対策-
    医薬ジャーナル社 2010
Lectures and oral presentations  (12)：
  • The functions of mycobacterial histone-like protein MDP1, a major protein in dormant mycobacteria
    (2019)
  • 潜在期結核菌抗原の精製と感染診断への応用
    (第55回日本細菌学会中部支部総会 2018)
  • 抗酸菌ヒストン様タンパク質による染色体制御における天然変性領域の役割
    (第55回日本細菌学会中部支部総会 2018)
  • Conditional control of mycobacterial DNA-binding protein 1 expression in mycobacteria
    (第91回日本細菌学会総会 2018)
  • Mycobacterial DNA-binding protein 1 is critical for long term survival of Mycobacterium smegmatis and simultaneously coordinates cellular functions
    (The 52nd US-Japan Mycobacteria Panel Meeting 2018)
ｍore...
Education (3)：
  • 2000 - 2003 Tohoku University Graduate School of Agricultural Science Department of Molecular and Cellular Biology
  • 1998 - 2000 Tohoku University Graduate School of Agricultural Science Department of Molecular and Cellular Biology
  • 1994 - 1998 Tohoku University Faculty of Agriculture Applied Biological Chemistry
Professional career (1)：
  • 博士(農学) (東北大学)
Work history (4)：
  • 2010/07 - 現在 Niigata University Department of Bacteriology, School of Medicine Lecturer
  • 2007/03 - 2010/06 Niigata University Department of Bacteriology, School of Medicine Assistant Professor
  • 2003/09 - 2007/01 Florida Atlantic University Charles E. Schmidt College of Biomedical Sciences Research Associate
  • 2003/06 - 2003/09 East Carolina University Department of Physiology, the Brody School of Medicine Research Associate
Association Membership(s) (3)：
American Society for Microbiology ,  JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY ,  JAPANESE SOCIETY FOR BACTERIOLOGY
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