Research field (3)：
Pharmaceuticals - chemistry and drug development
, Molecular biology
, Structural biochemistry
Research keywords (7)：
化合物スクリーニング
, cryoEM / single particle analysis
, biochemistry
, hem-copper oxide reductase
, cytochrome c oxidase
, Thermus
, X-ray crystal structure analysis
Research theme for competitive and other funds (6)：
2024 - 2025 進化的に隠されたアロステリーを利用した特異的阻害剤
2023 - 2025 進化的に隠されたアロステリック部位の探索方法確立と抗菌薬開発への展開
2022 - 2023 新規アロステリーによる特異的抗菌薬の合理的創出
2021 - 2023 呼吸鎖酵素の新規アロステリック調節機構の証明と抗菌剤開発への展開
2017 - 2020 Analysis of the regulatory mechanism of the activity of cardiac specific myosin light chain kinase
2011 - 2013 ヌクレオイド構成タンパク質 HU を手がかりとした核様体システムの解明
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Papers (11)：
Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Satoshi Ogasawara, Ken Shimuta, Takashi Iwamoto, Chisa Nakabayashi, et al. Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases. Nature Communications. 2022. 13. 1. 7591-7591
Masaru Kato, Ryoya Sano, Narumi Yoshida, Masatoshi Iwafuji, Yoshito Nishiyama, Sayuki Oka, Kyoko Shinzawa-Itoh, Yuya Nishida, Yasunori Shintani, Ichizo Yagi. Effects of Interfacial Interactions on Electrocatalytic Activity of Cytochrome c Oxidase in Biomimetic Lipid Membranes on Gold Electrodes. The Journal of Physical Chemistry Letters. 2022. 13. 39. 9165-9170
Shohei Yashirogi, Takemasa Nagao, Yuya Nishida, Yusuke Takahashi, Tasneem Qaqorh, Issei Yazawa, Toru Katayama, Hidetaka Kioka, Tsubasa S Matsui, Shigeyoshi Saito, et al. AMPK regulates cell shape of cardiomyocytes by modulating turnover of microtubules through CLIP-170. EMBO reports. 2020
Takemasa Nagao, Yasunori Shintani, Takaharu Hayashi, Hidetaka Kioka, Hisakazu Kato, Yuya Nishida, Satoru Yamazaki, Osamu Tsukamoto, Shohei Yashirogi, Issei Yazawa, et al. Higd1a improves respiratory function in the models of mitochondrial disorder. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020. 34. 1. 1859-1871
Kenta Kamikubo, Hisakazu Kato, Hidetaka Kioka, Satoru Yamazaki, Osamu Tsukamoto, Yuya Nishida, Yoshihiro Asano, Hiromi Imamura, Hiroyuki Kawahara, Yasunori Shintani, et al. A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 2. The Journal of biological chemistry. 2019. 294. 40. 14562-14573
Conserved allostery buried inside mitochondrial heme-copper oxidases can generate novel antibiotics. Journal of Japanese Biochemical Society. 2024. 96. 3. 359-363
Yuya NISHIDA, Yasunori SHINTANI. Identifying Antibiotics Based on Structural Differences in the Conserved Allostery from Mitochondrial Respiratory Complex IV. Seibutsu Butsuri. 2023. 63. 5. 273-275
Yuya Nishida, Yasunori Shintani. Evolutionally conserved allostery in heme-copper oxidases can generate pathogen-specific antibiotics. Biochimica et Biophysica Acta (BBA) - Bioenergetics. 2022. 1863. 148673-148673
