Rchr
J-GLOBAL ID：201801018333869114   Update date: May. 01, 2024

Takahashi-KANEMITSU Atsushi

カネミツ アツシ | Takahashi-KANEMITSU Atsushi
Affiliation and department：
Juntendo University Department of Biochemistry & Systems Biomedicine

About Juntendo University Department of Biochemistry & Systems Biomedicine


Job title： Assistant Professor
Other affiliations (2)：
  • Juntendo University  Nakatani Biomedical Spatialomics Hub (Nakatani-BSH), Graduate School of Medicine   Assistant Professor
  • Juntendo University  Division of Biochemistry II, Faculty of Medicine   Assistant Professor
Homepage URL  (2)： http://www.dbsb.science ,  https://www.researchgate.net/profile/Atsushi_Takahashi-Kanemitsu
Research field  (3)： Cell biology ,  Molecular biology ,  Tumor biology
Research keywords  (12)： Senescence ,  Aging ,  Tissue-clearing ,  Laboratory automation ,  Genetically engineered mice ,  Cancer organoid ,  Intracellular signal transduction ,  Epithelial cell polarity ,  Protein phosphorylation ,  CagA ,  Helicobacter pylori ,  Carcinogenesis
Research theme for competitive and other funds  (10)：
  • 2024 - 2025 3D-Fluorescent Imaging of a Whole Mouse Stomach towards the Development of a Whole-Cell Atlas with Subcellular Resolution
  • 2023 - 2024 多細胞システム解明に向けた技術開発と再生医学・疾患研究応用
  • 2022 - 2023 Elucidation of the Mechanism of Gastric Carcinogenesis by Host Response to Helicobacter pylori
  • 2022 - 2023 多細胞システム解明に向けた技術開発と再生医学・疾患研究応用
  • 2019 - 2022 Understanding of the Mechanism of Gastric Carcinogenesis by the Development of the System that Visualizes Dynamics of the Planar Cell Polarity within Gastric Epithelial Organoids
Show all
Papers (17)：
  • 金光 昌史, 畠山 昌則. Mechanisms of gastric carcinogenesis induced by Helicobacter pylori CagA oncoprotein. Japanese Journal of Helicobacter Research. 2024. 26. 1
  • Akira L Yoshikawa, Takaki Omura, Atsushi Takahashi-Kanemitsu, Etsuo A Susaki. Blueprints from plane to space: outlook of next-generation three-dimensional histopathology. Cancer Science. 2024
  • Ippei Kikuchi, Yusuke Iwashita, Atsushi Takahashi-Kanemitsu, Michinori Koebis, Atsu Aiba, Masanori Hatakeyama. Coevolution of the ileum with Brk/Ptk6 family kinases confers robustness to ileal homeostasis. <I><b>Biochemical and Biophysical Research Communications</I></b>. 2023. 676. 190-197
  • Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, Akira Kikuchi, Nick Barker, et al. The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric gland base cells. Science Signaling. 2023. 16. 794. eabp9020
  • Kamurunnesa Tahmina, Narumi Hikawa, Atsushi Takahashi-Kanemitsu, Christopher T Knight, Kengo Sato, Fumiko Itoh, Masanori Hatakeyama. Transgenically expressed Helicobacter pylori CagA in vascular endothelial cells accelerates arteriosclerosis in mice. Biochemical and Biophysical Research Communications. 2022. 618. 79-85
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MISC (2)：
  • Atsushi Takahashi-Kanemitsu, Mengxue Lu, Masanori Hatakeyama. The Helicobacter pylori CagA oncoprotein disrupts Wnt/PCP signaling and promotes hyperproliferation of pyloric base cells. Japanese Scientists in Science Signaling 2023. 2024
  • Atsushi Takahashi-Kanemitsu, Mengxue Lu, Christopher Takaya Knight, Takayoshi Yamamoto, Takuo Hayashi, Yusuke Mii, Takuya Ooki, Ippei Kikuchi, A. Cover Image <I>Science Signaling</I> 16(794), 2023. <I><B>Science Signaling</I></B>. 2023. 16. 794. eabp9020
Books (6)：
  • セルオミクスが実現するオルガノイドの全細胞解析
    <B>実験医学 増刊</B>「オルガノイドがもたらすライフサイエンス革命」あなたの研究に、どう使う?進化と深化を生む未来型研究30選[武部貴則/編]・羊土社 2024 ISBN:9784758104173
  • ピロリ菌感染が引き起こす胃上皮幹細胞ニッチにおける平面内細胞極性の脱制御
    <b>実験医学</b> 「AI・シュミレーションによる科学的発見は可能か?」Current Topics 2024年1月号 42(1)・羊土社 2023 ISBN:9784758125758
  • ピロリ菌CagAが主導する胃発がんスパイラルにおけるHippo経路の役割
    <b>実験医学</b>「発生・器官形成、がん悪性化に関わるHippoシグナル」33(18)・羊土社 2015
  • Hippo経路のエフェクター分子YAPおよびTAZによるがんタンパク質SHP2の機能制御
    <b>細胞工学</b>「新メカノトランスダクション」33(9) Special Review・学研メディカル秀潤社 2014
  • チロシンホスファターゼSHP2による核における基質タンパク質parafibrominを介したWnt経路の活性化
    <b>ライフサイエンス新着論文レビュー First Author’s</b> 2011
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Lectures and oral presentations  (53)：
  • Mechanism of gastric carcinogenesis via Wnt/PCP signal, a novel target perturbed by <i>H. pylori</i> CagA
    (2024)
  • A novel prooncogenic activity of <i>Helicobacter pylori</i> CagA oncoprotein: Deregulation of Wnt/Planar cell polarity signaling by VANGL inhibition. [Young Investigator Award Lecture]
    (<b>The 20th Japan-Korea Joint Symposium on <i>Helicobacter</i> Infection</b> 2024)
  • Identification of Wnt/PCP signaling as a target of <I>H. pylori</I> CagA oncoprotein, using <I>Xenopus</I> embryos
    (<b>2024 Annual Meeting of Japanese Association for Laboratory Animal Science</b> 2024)
  • ヘリコバクター・ピロリのがんタンパク質CagAは胃上皮幹細胞の運命制御を撹乱して胃発がんを促進する
    (<b>ゲノム・再生医療センター研究成果報告会</b> 2024)
  • ピロリ菌が胃がん発症を促進する新たな分子メカニズム --カエル胚の発生異常の解析を手がかりに--
    (<b>第38回 <I>Science</i> Cafe</b> 2024)
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Education (5)：
  • 2009 - 2011 The University of Tokyo Div. of Microbiology (Prof. Masanori Hatakeyama), Grad. Sch. of Medicine Visiting Student
  • 2006 - 2011 Hokkaido University @Div. of Molecular Oncology (Prof. Masanori Hatakeyama), Institute for Genetic Medicine PhD Course in Chemistry, Grad. Sch. of Science
  • 2004 - 2006 Hokkaido University @Div. of Molecular Oncology (Prof. Masanori Hatakeyama), Institute for Genetic Medicine Master Course in Chemistry, Grad. Sch. of Science
  • 2000 - 2004 Hokkaido University Fac. of Science Div. in Chemistry
  • 1997 - 2000 Hokkaido Sappro Kita High School
Professional career (1)：
  • Ph. D. in Science, Chemistry (Hokkaido University)
Work history (5)：
  • 2024/04 - 現在 Juntendo University Nakatani Biomedical Spatialomics Hub (Nakatani-BSH), Graduate School of Medicine (Prof. Etuso A. Susaki) Assistant Professor
  • 2022/01 - 現在 Juntendo University Grad. Sch. of Medicine Dept. of Biochemistry & Systems Biomedicine (Prof. Etsuo A. Susaki) Assistant Professor
  • 2013/04 - 2021/12 The University of Tokyo Div. of Microbiology (Prof. Masanori Hatakeyama), Fac. and Grad. Sch. of Medicine Research Associate
  • 2011/10 - 2013/03 The University of Tokyo Div. of Microbiology (Prof. Masanori Hatakeyama), Grad. Sch. of Medicine Postdoctoral Researcher
  • 2007/04 - 2009/03 Japan Society for the Promotion of Science (JSPS) Research Fellow (DC2)
Awards (4)：
  • 2024/04 - The Japanese Society of <i>Helicobacter</i> Research (JSHR) & Korean College of <i>Helicobacter</i> and Upper Gastrointestinal Research (HUG) <b>Young Investigator Award, The 20th Japan-Korea Joint Symposium on <i>Helicobacter pylori</i> Infection </b> A Novel Prooncogenic Activity of <i>Helicobacter pylori</i> CagA Oncoprotein: Deregulation of Wnt/Planar Cell Polarity Signaling by VANGL Inhibition
  • 2024/03 - The Japanese Society for <i>Helicobacter</i> Research (JSHR) <b>Research Award of the Japanese Society for <i>Helicobacter</i> Research, in Medical Science</b> Identification of Intracellular Signaling Pathways Perturbed by <i>H. pylori</i> CagA and Elucidation of the Pathophysiological Significance Using <i>cagA</i>-transgenic Mice
  • 2011 - Japanese Association for Protein Phosphatase Research (JAPPR) <b>Research Award of the Japanese Association for Protein Phosphatase Research</b> “SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver.”
  • 2007 - Japan Society for the Promotion of Science (JSPS) <b>Research Fellowship for Young Scientists (DC2)</b> “Comprehensive Analysis of Intracellular Substrates for SHP2 Tyrosine Phospatase”
Association Membership(s) (7)：
Japanese Association for Laboratory Animal Science ,  The Japanese Society for <I>Helicobacter</I> Research ,  The Zoological Society of Japan ,  Wnt研究会 ,  Japanese Association for Protein Phosphatase Research ,  The Molecular Biology Society of Japan ,  The Japanese Cancer Association
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