YOSHIHARA KOSUKE

• 2024 - 2027 正常組織における変異クローンの空間的増殖を誘導する遺伝・環境要因相互作用の解明
• 2024 - 2027 子宮内膜オルガノイドを用いた子宮内膜症の病態解明
• 2024 - 2027 婦人科がん幹細胞と特異的腫瘍免疫ネットワークの関係性を標的とした新規治療法の探索
• 2024 - 2027 Construction of gene expression atlas of normal endometrium and elucidation of regeneration mechanism by spatial omics analysis
• 2024 - 2027 胎児低酸素血症のサイン「遅発一過性徐脈」先行予測AIの開発
2023 - 2027 Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues
2022 - 2025 Identification of the significance of cancer-associated gene mutations in normal endometrium
2021 - 2024 空間的遺伝子発現解析による明細胞癌の治療抵抗性ネットワークの解明
2020 - 2023 Elucidation of pathogenesis of endometriosis and endometriosis-associated ovarian cancer based on genomic analyses for normal endometrium
2020 - 2023 Elucidation of the pathogenesis of ovarian endometrioid carcinoma using single cell sequencing
2020 - 2022 Identification of pathogenesis of ovarian clear cell carcinoma by topographic single cell sequencing
2019 - 2022 New metastatic pathway via mesenteric lymph node involvement in ovarian cancer liver metastasis
2019 - 2022 Elucidation of the pathogenesis of endometriosis based on the integrated OMICS data analyses
2017 - 2020 Identification of the pathogenesis from the origin to uterine carcinosarcoma based on evolutional theory
2016 - 2019 Identification of genomic linkage from ovarian endometriosis to endometrioid carcinoma based on sequential OMICS data analysis
2016 - 2019 Genetic analysis of 19 susceptibility genes including BRCA1/2 genes in ovarian cancer
2016 - 2019 Identification of the pathogenesis of ovarian cancer based on fusion gene profile
2015 - 2018 Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin
2015 - 2017 Elucidating the mechanism of resistance to chemotherapy in gynecologic cancer based on intratumor heterogeneity
2011 - 2011 Significance of copy-neutral LOH in epithelial ovarian cancer
2009 - 2011 Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

• Shinichi Tate, Toshiyuki Seki, Kyoko Nishikimi, Youichi Unno, Mizue Itoi, Sadatomo Ikeda, Nobuhisa Yoshikawa, Hidehiko Akashi, Eitaro Suzuki, Naotake Tanaka, et al. Bevacizumab in frontline chemotherapy improved the survival outcome for advanced ovarian clear cell carcinoma: a multicenter retrospective analysis. Journal of gynecologic oncology. 2025
• Masato Nakano, Yoshifumi Shimada, Hikaru Ozeki, Akio Matsumoto, Mae Nakano, Shuhei Kondo, Ryosuke Goto, Nozomi Yachida, Kosuke Yoshihara, Toshifumi Wakai. A case of deep endometriosis with cyst formation as a differential diagnosis of rectal duplication cyst in the presacral space. Clinical journal of gastroenterology. 2025
• Tatsuya Katsumi, Ryota Hayashi, Shingo Takei, Osamu Ansai, Sumiko Takatsuka, Tatsuya Takenouchi, Kyota Saito, Kazuaki Suda, Kosuke Yoshihara, Takahiro Nagai, et al. Reevaluating hybrid neurofibroma/schwannoma: Predominance of schwannoma features despite CD34 positivity and initial neurofibroma diagnosis. The Journal of dermatology. 2024. 51. 11. 1461-1469
• Hiroto Yamamoto, Kaoru Yamawaki, Kazufumi Haino, Kosuke Yoshihara, Koji Nishijima. Influence of Warning Bleeding on Blood Loss in Low-Lying Placenta. Cureus. 2024. 16. 11. e74858
• Shiro Takamatsu, R Tyler Hillman, Kosuke Yoshihara, Tsukasa Baba, Muneaki Shimada, Hiroshi Yoshida, Hiroaki Kajiyama, Katsutoshi Oda, Masaki Mandai, Aikou Okamoto, et al. Molecular classification of ovarian high-grade serous/endometrioid carcinomas through multi-omics analysis: JGOG3025-TR2 study. British journal of cancer. 2024. 131. 8. 1340-1349

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• 山田 貴穂, 柳生田 紀子, 西島 浩二, 小川 洋平, 谷内 洋子, 吉原 弘祐, 曽根 博仁. 妊娠糖尿病合併妊婦における産後糖代謝異常リスクの検討. 糖尿病と妊娠. 2023. 23. 3. S-115
• 柳生田 紀子, 山田 貴穂, 西島 浩二, 有森 直子, 小川 洋平, 吉原 弘祐, 曽根 博仁. 新潟大学医歯学総合病院における糖代謝異常合併妊娠に関する周産期レジストリーの構築. 糖尿病と妊娠. 2023. 23. 3. S-115
• 吉原 弘祐, 榎本 隆之. 【婦人科がん機能温存治療のすべて】子宮頸がん 広汎子宮頸部摘出術. 産科と婦人科. 2021. 88. 7. 824-828
• 吉原 弘祐, 榎本 隆之. 【ゲノム時代の生殖内分泌学】ゲノムと子宮内膜症. HORMONE FRONTIER IN GYNECOLOGY. 2021. 28. 2. 111-114
• 吉原 弘祐, 榎本 隆之. 【卵巣癌におけるHRDとPARP阻害薬の効果】卵巣癌の臨床像とHRD. 産婦人科の実際. 2021. 70. 5. 495-499

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• 2006 - 2009 Niigata University Graduate School of Medical and Dental Sciences
• 1997 - 2003 Niigata University School of Medicine

• 博士号 (新潟大学大学院医歯学総合研究科)

• 2022/09 - 現在 Niigata University Graduate School of Medical and Dental Sciences Department of Obstetrics and Gynecology Professor
• 2021/07 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
• 2021/02 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
• 2016/10 - 2022/08 Niigata University Institute for Research Promotion Research Associate Professor
• 2014/07 - 2021/01 Niigata University Graduate School of Medical Department of Obstetrics and Gynecology Assistant professor
2012/01 - 2014/06 University of Texas MD Anderson Cancer Center Department of Bioinformatics and Computational Biology Postdoctoral fellow
2009/04 - 2011/12 Niigata University Graduate School of Medical and Dental Sciences Department of Obstetrics and Gynecology Assistant professor
2003/05 - 2006/03 Niigata University School of Medicine Department of Obstetrics and Gynecology

• 2020/03 - 現在 日本遺伝性乳癌卵巣癌総合診療制度機構 ガイドライン委員
• 2017/12 - 現在 日本婦人科腫瘍学会 代議員
• 2020/12 - 2021/07 日本婦人科腫瘍学会 子宮頸癌治療ガイドライン委員
• 2017/10 - 2020/03 日本癌学会・日本臨床腫瘍学会・日本癌治療学会 3学会合同ゲノム医療推進タスクフォース がんゲノム医療ネットワーキンググループ

• 2016/06 - Yujin Society Yujin Memorial Research Award

日本がん・生殖医療学会 ,  The Japanese Society of Clinical Cytology ,  THE JAPAN SOCIETY OF HUMAN GENETICS ,  Japan Association for Medical Artificial Intelligence ,  THE JAPAN SOCIETY FOR MENOPAUSE AND WOMEN'S HEALTH ,  American Society of Clinical Oncology ,  American Association for Cancer Research ,  JAPAN SOCIETY OF GYNECOLOGIC ONCOLOGY ,  JAPAN SOCIETY OF CLINICAL ONCOLOGY ,  THE JAPANESE CANCER ASSOCIATION ,  JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY