YOSHIHARA KOSUKE

• 2023 - 2027 Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues
• 2022 - 2025 Identification of the significance of cancer-associated gene mutations in normal endometrium
• 2020 - 2023 Elucidation of pathogenesis of endometriosis and endometriosis-associated ovarian cancer based on genomic analyses for normal endometrium
• 2020 - 2023 単一細胞シークエンスを用いた卵巣類内膜癌の発症機序の解明
• 2020 - 2022 Identification of pathogenesis of ovarian clear cell carcinoma by topographic single cell sequencing
2019 - 2022 New metastatic pathway via mesenteric lymph node involvement in ovarian cancer liver metastasis
2019 - 2022 Elucidation of the pathogenesis of endometriosis based on the integrated OMICS data analyses
2017 - 2020 Identification of the pathogenesis from the origin to uterine carcinosarcoma based on evolutional theory
2016 - 2019 Identification of genomic linkage from ovarian endometriosis to endometrioid carcinoma based on sequential OMICS data analysis
2016 - 2019 Genetic analysis of 19 susceptibility genes including BRCA1/2 genes in ovarian cancer
2016 - 2019 Identification of the pathogenesis of ovarian cancer based on fusion gene profile
2015 - 2018 Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin
2015 - 2017 Elucidating the mechanism of resistance to chemotherapy in gynecologic cancer based on intratumor heterogeneity
2011 - 2011 Significance of copy-neutral LOH in epithelial ovarian cancer
2009 - 2011 Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

• Yosuke Konno, Michinori Mayama, Kazuhiro Takehara, Yoshihito Yokoyama, Jiro Suzuki, Nobuyuki Susumu, Kenichi Harano, Satoshi Nakagawa, Toru Nakanishi, Wataru Yamagami, et al. Prognostic impact of the number of resected pelvic nodes in endometrial cancer: Japanese Gynecologic Oncology Group Study JGOG2043 post hoc analysis. Journal of gynecologic oncology. 2024
• Noriyuki Okonogi, Keisuke Tsuchida, Ken Ando, Tatsuya Ohno, Hiroyuki Fujiwara, Kosuke Yoshihara, Takuya Aoki, Hirokuni Takano, Munetaka Takekuma, Aikou Okamoto, et al. Significance of definitive concurrent chemoradiotherapy for vulvar cancer: a Japanese Gynecologic Oncology Group nationwide survey study. Japanese journal of radiology. 2024
• Eiri Shima, Kazufumi Haino, Shunya Sugai, Kazuaki Suda, Koji Nishijima, Kosuke Yoshihara. A case of fetal hydrops caused by generalized arterial calcification of infancy. Journal of medical ultrasonics (2001). 2024. 51. 2. 367-368
• Yutaro Mori, Yoshie Okimoto, Hiroaki Sakai, Yusuke Kanda, Hirokazu Ohata, Daisuke Shiokawa, Mikiko Suzuki, Hiroshi Yoshida, Haruka Ueda, Tomoyuki Sekizuka, et al. Targeting PDGF signaling of cancer-associated fibroblasts blocks feedback activation of HIF-1α and tumor progression of clear cell ovarian cancer. Cell Reports Medicine. 2024. 101532-101532
• Kotaro Takahashi, Nozomi Yachida, Ryo Tamura, Sosuke Adachi, Shuhei Kondo, Tatsuya Abé, Hajime Umezu, Hiromi Nyuzuki, Shujiro Okuda, Hirofumi Nakaoka, et al. Clonal origin and genomic diversity in Lynch syndrome-associated endometrial cancer with multiple synchronous tumors: Identification of the pathogenicity of MLH1 p.L582H. Genes, Chromosomes and Cancer. 2024. 63. 3

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• 吉原 弘祐, 榎本 隆之. 【婦人科がん機能温存治療のすべて】子宮頸がん 広汎子宮頸部摘出術. 産科と婦人科. 2021. 88. 7. 824-828
• 吉原 弘祐, 榎本 隆之. 【ゲノム時代の生殖内分泌学】ゲノムと子宮内膜症. HORMONE FRONTIER IN GYNECOLOGY. 2021. 28. 2. 111-114
• 吉原 弘祐, 榎本 隆之. 【卵巣癌におけるHRDとPARP阻害薬の効果】卵巣癌の臨床像とHRD. 産婦人科の実際. 2021. 70. 5. 495-499
• Yutaro Mori, Kaoru Yamawaki, Tatsuya Ishiguro, Kosuke Yoshihara, Yusuke Kanda, Daisuke Shiokawa, Takayuki Enomoto, Koji Okamoto. Identification of cellular networks for chemoresistance of ovarian clear cell cancers through single nucleus analysis. CANCER SCIENCE. 2021. 112. 375-375
• 中野麻恵, 島田能史, 吉原弘祐, 西野幸治, 関根正幸, 齋木琢郎, 松本吉史, 西條康夫, 棗田学, 今井千速, et al. Current status of genomic profiling using cancer gene panel testing in Niigata University Medical & Dental Hospital. 日本臨床腫瘍学会学術集会(CD-ROM). 2021. 18th

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• 2006 - 2009 Niigata University Graduate School of Medical and Dental Sciences
• 1997 - 2003 Niigata University School of Medicine

• 博士号 (新潟大学大学院医歯学総合研究科)

• 2022/09 - 現在 Niigata University Graduate School of Medical and Dental Sciences Department of Obstetrics and Gynecology Professor
• 2021/07 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
• 2021/02 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
• 2016/10 - 2022/08 Niigata University Institute for Research Promotion Research Associate Professor
• 2014/07 - 2021/01 Niigata University Graduate School of Medical Department of Obstetrics and Gynecology Assistant professor
2012/01 - 2014/06 University of Texas MD Anderson Cancer Center Department of Bioinformatics and Computational Biology Postdoctoral fellow
2009/04 - 2011/12 Niigata University Graduate School of Medical and Dental Sciences Department of Obstetrics and Gynecology Assistant professor
2003/05 - 2006/03 Niigata University School of Medicine Department of Obstetrics and Gynecology

• 2020/12 - 現在 日本婦人科腫瘍学会 子宮頸癌治療ガイドライン委員
• 2020/03 - 現在 日本遺伝性乳癌卵巣癌総合診療制度機構 ガイドライン委員
• 2017/12 - 現在 日本婦人科腫瘍学会 代議員
• 2017/10 - 2020/03 日本癌学会・日本臨床腫瘍学会・日本癌治療学会 3学会合同ゲノム医療推進タスクフォース がんゲノム医療ネットワーキンググループ

• 2016/06 - Yujin Society Yujin Memorial Research Award

日本がん・生殖医療学会 ,  The Japanese Society of Clinical Cytology ,  THE JAPAN SOCIETY OF HUMAN GENETICS ,  Japan Association for Medical Artificial Intelligence ,  THE JAPAN SOCIETY FOR MENOPAUSE AND WOMEN'S HEALTH ,  American Society of Clinical Oncology ,  American Association for Cancer Research ,  JAPAN SOCIETY OF GYNECOLOGIC ONCOLOGY ,  JAPAN SOCIETY OF CLINICAL ONCOLOGY ,  THE JAPANESE CANCER ASSOCIATION ,  JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY