YOSHIHARA KOSUKE

Affiliation and department：
Job title： Professor

Research field (4)： Genomics , Biological, health, and medical informatics , Computational science , Tumor biology

Research keywords (4)： Computational Biology , Bioinformatics , Gynecologic Oncology , Obstetrics and Gynecology

Research theme for competitive and other funds (21)：

2024 - 2027 正常組織における変異クローンの空間的増殖を誘導する遺伝・環境要因相互作用の解明
2024 - 2027 子宮内膜オルガノイドを用いた子宮内膜症の病態解明
2024 - 2027 婦人科がん幹細胞と特異的腫瘍免疫ネットワークの関係性を標的とした新規治療法の探索
2024 - 2027 Construction of gene expression atlas of normal endometrium and elucidation of regeneration mechanism by spatial omics analysis
2024 - 2027 胎児低酸素血症のサイン「遅発一過性徐脈」先行予測AIの開発

2023 - 2027 Gene-environment interactions inducing spatial expansion of mutant clones in human normal tissues

2022 - 2025 Identification of the significance of cancer-associated gene mutations in normal endometrium

2021 - 2024 空間的遺伝子発現解析による明細胞癌の治療抵抗性ネットワークの解明

2020 - 2023 Elucidation of pathogenesis of endometriosis and endometriosis-associated ovarian cancer based on genomic analyses for normal endometrium

2020 - 2023 Elucidation of the pathogenesis of ovarian endometrioid carcinoma using single cell sequencing

2020 - 2022 Identification of pathogenesis of ovarian clear cell carcinoma by topographic single cell sequencing

2019 - 2022 New metastatic pathway via mesenteric lymph node involvement in ovarian cancer liver metastasis

2019 - 2022 Elucidation of the pathogenesis of endometriosis based on the integrated OMICS data analyses

2017 - 2020 Identification of the pathogenesis from the origin to uterine carcinosarcoma based on evolutional theory

2016 - 2019 Identification of genomic linkage from ovarian endometriosis to endometrioid carcinoma based on sequential OMICS data analysis

2016 - 2019 Genetic analysis of 19 susceptibility genes including BRCA1/2 genes in ovarian cancer

2016 - 2019 Identification of the pathogenesis of ovarian cancer based on fusion gene profile

2015 - 2018 Clarification of molecular biological feature of Mullerian endometrioid adenocarcinoma and establishment of differentiation of its origin

2015 - 2017 Elucidating the mechanism of resistance to chemotherapy in gynecologic cancer based on intratumor heterogeneity

2011 - 2011 Significance of copy-neutral LOH in epithelial ovarian cancer

2009 - 2011 Down regulation of antigen presentation pathway plays an important role in metastasis and progression of advanced stage of epithelial ovarian cancer.

Show all

Papers (226)：

Hiroto Yamamoto, Kaoru Yamawaki, Kazufumi Haino, Kosuke Yoshihara, Koji Nishijima. Influence of Warning Bleeding on Blood Loss in Low-Lying Placenta. Cureus. 2024. 16. 11. e74858
Shiro Takamatsu, R Tyler Hillman, Kosuke Yoshihara, Tsukasa Baba, Muneaki Shimada, Hiroshi Yoshida, Hiroaki Kajiyama, Katsutoshi Oda, Masaki Mandai, Aikou Okamoto, et al. Molecular classification of ovarian high-grade serous/endometrioid carcinomas through multi-omics analysis: JGOG3025-TR2 study. British journal of cancer. 2024. 131. 8. 1340-1349
Haruka Ueda, Tatsuya Ishiguro, Yutaro Mori, Kaoru Yamawaki, Koji Okamoto, Takayuki Enomoto, Kosuke Yoshihara. Glycolysis-mTORC1 crosstalk drives proliferation of patient-derived endometrial cancer spheroid cells with ALDH activity. Cell death discovery. 2024. 10. 1. 435-435
Shunya Sugai, Yutaro Mori, Kaoru Yamawaki, Eiri Shima, Mitsuru Matsushita, Kosuke Yoshihara, Koji Nishijima. Temporal trends and regional variations in operative vaginal deliveries in Japan: A national representative cohort study. The journal of obstetrics and gynaecology research. 2024. 50. 9. 1494-1500
Shunya Sugai, Kazufumi Haino, Kaoru Yamawaki, Kosuke Yoshihara, Koji Nishijima. Pregnancy Following Spontaneous Healing of Uterine Rupture: A Case Report and Experience of Management. Cureus. 2024. 16. 9. e70322

ｍore...

MISC (81)：

山田貴穂, 柳生田紀子, 西島浩二, 小川洋平, 谷内洋子, 吉原弘祐, 曽根博仁. 妊娠糖尿病合併妊婦における産後糖代謝異常リスクの検討. 糖尿病と妊娠. 2023. 23. 3. S-115
柳生田紀子, 山田貴穂, 西島浩二, 有森直子, 小川洋平, 吉原弘祐, 曽根博仁. 新潟大学医歯学総合病院における糖代謝異常合併妊娠に関する周産期レジストリーの構築. 糖尿病と妊娠. 2023. 23. 3. S-115
吉原弘祐, 榎本隆之. 【婦人科がん機能温存治療のすべて】子宮頸がん広汎子宮頸部摘出術. 産科と婦人科. 2021. 88. 7. 824-828
吉原弘祐, 榎本隆之. 【ゲノム時代の生殖内分泌学】ゲノムと子宮内膜症. HORMONE FRONTIER IN GYNECOLOGY. 2021. 28. 2. 111-114
吉原弘祐, 榎本隆之. 【卵巣癌におけるHRDとPARP阻害薬の効果】卵巣癌の臨床像とHRD. 産婦人科の実際. 2021. 70. 5. 495-499

ｍore...

Education (2)：

2006 - 2009 Niigata University Graduate School of Medical and Dental Sciences
1997 - 2003 Niigata University School of Medicine

Professional career (1)：

博士号 (新潟大学大学院医歯学総合研究科)

Work history (8)：

2022/09 - 現在 Niigata University Graduate School of Medical and Dental Sciences Department of Obstetrics and Gynecology Professor
2021/07 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
2021/02 - 2022/08 Niigata University Graduate School of Medical and Dental Sciences Obstetrics and Gynecology Associate Professor
2016/10 - 2022/08 Niigata University Institute for Research Promotion Research Associate Professor
2014/07 - 2021/01 Niigata University Graduate School of Medical Department of Obstetrics and Gynecology Assistant professor

Show all

Committee career (4)：

2020/03 - 現在日本遺伝性乳癌卵巣癌総合診療制度機構ガイドライン委員
2017/12 - 現在日本婦人科腫瘍学会代議員
2020/12 - 2021/07 日本婦人科腫瘍学会子宮頸癌治療ガイドライン委員
2017/10 - 2020/03 日本癌学会・日本臨床腫瘍学会・日本癌治療学会 3学会合同ゲノム医療推進タスクフォースがんゲノム医療ネットワーキンググループ

Awards (1)：

2016/06 - Yujin Society Yujin Memorial Research Award

Association Membership(s) (11)：

日本がん・生殖医療学会 , The Japanese Society of Clinical Cytology , THE JAPAN SOCIETY OF HUMAN GENETICS , Japan Association for Medical Artificial Intelligence , THE JAPAN SOCIETY FOR MENOPAUSE AND WOMEN'S HEALTH , American Society of Clinical Oncology , American Association for Cancer Research , JAPAN SOCIETY OF GYNECOLOGIC ONCOLOGY , JAPAN SOCIETY OF CLINICAL ONCOLOGY , THE JAPANESE CANCER ASSOCIATION , JAPAN SOCIETY OF OBSTETRICS AND GYNECOLOGY

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page