Zhu Bo

シュハク | Zhu Bo

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Applied biofunctional and bioprocess engineering , Applied biochemistry , Molecular biology , Applied microbiology

Research keywords (5)：高速分子進化 , 抗体工学 , 酵素工学 , タンパク質言語モデル , バイオセンサ

Research theme for competitive and other funds (10)：

2024 - 2026 Creatation of antiboy-peptide-nucleic acid conjugates with switch function and its application in a high-sensitive homogeneous detection system
2023 - 2025 将来のパンデミックに備えた迅速対応基盤
2024 - Exploration of microdroplet-based screening methods for rapid engineering of biosensor, bacteria, and functional protein
2023 - 2024 Universal Bio and AI tools for high-throughput engineering of functional proteins
2023 - 2024 Development of hyperstable homogeneous biosensors for virus and cytokine detections

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Papers (20)：

Kana Sasamoto, Takanobu Yasuda, Bo Zhu, Hiroshi Ueda, Tetsuya Kitaguchi. Efficient and rapid linker optimization with heterodimeric coiled coils improves the response of fluorescent biosensors comprising antibody and protein M. Analyst. 2023. 148. 5843-5850
Bo Zhu, Yukihiko Yamasaki, Takanobu Yasuda, Cheng Qian, Zhirou Qiu, Hiroshi Ueda, Tetsuya Kitaguchi. Customizable OpenGUS immunoassay: a homogeneous detection system using split β-glucuronidase and label-free antibody. Jxiv. 2023. preprint
Bo Zhu, Zhe Du, Yancen Dai, Tetsuya Kitguchi, Sebastian Behrens, Burckhard Seelig. Nanodroplet-Based Reagent Delivery into Water-in-Fluorinated-Oil Droplets. Biosensors. 2023. 13. 8. 768
Satoshi Okada, Yuka Muto, Bo Zhu, Hiroshi Ueda, Hiroyuki Nakamura. Development of a peptide sensor derived from human ACE2 for fluorescence polarization assays of the SARS-CoV-2 receptor binding domain. Analytical Chemistry. 2023. 95. 15. 6198-6202
Abdul Qawee Rani, Bo Zhu, Hiroshi Ueda, Tetsuya Kitaguchi. Recent progress in homogeneous immunosensors based on fluorescence or bioluminescence using antibody engineering. Analyst. 2023. 148. 1422-1429

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MISC (1)：

Alfi Almasul, Zhu Bo, Damnjanovic Jasmina, Kojima Takaaki, Iwasaki Yugo, Nakano Hideo. 3P-024 Expression of the manganese peroxidase from Phanerochaete chrysosporium expressed in chaperone overexpressing Escherichia coli :. 2015. 67. 276-276

Books (2)：

Construction of a DNA library on microbeads using whole genome amplification. In: Kroneis T. (eds) Whole Genome Amplification, Methods in Molecular Biology, vol 1347
Humana Press 2015
切らずに開く酵素スイッチ
日本化学会バイオテクノロジー部ニュースレターVol. 27, No. 2 (2024. 03. 27)

Lectures and oral presentations (8)：

A customizable one-pot detection system using β-glucuronidase switch and label-free antibody
(SCEJ 89th Annual Meeting 2024)
Development of diverse immunosensors through rapid molecular evolutions and deep learning
(2024)
Molecular and whole-cell immunosensors developed by directed evolution for applications in diagnostics and food-safety control
(Biotechnology Institute Seminar 2023 Fall, University of Minnesota 2023)
Rapid development of single fluorescent protein-based immunosensor Flashbody through ultra-high-throughput screening and cell-free protein synthesis
(The 75th Annual Meeting of the Society Biotechnology, Japan 2023)
Converting antibodies to rapid response SARS-CoV-2 homogeneous immunosensors via Quenchbody technology and crowding agent
(2022)

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Education (1)：

Professional career (2)：

Work history (6)：

2023/03 - 現在 HikariQ Health R&D General Manager
2020/05 - 現在 Tokyo Institute of Technology Laboratory for Chemistry and Life Science, Institute of Innovative Research Assistant professor
2023/10 - 2023/11 University of California, Los Angeles Visiting scholar
2018/07 - 2020/04 Kobe University Graduate School of Science, Technology and Innovation Postdoctoral Associate
2016/05 - 2018/05 University of Minnesota Twin Cities BioTechnology Institute Postdoctoral Associate

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Committee career (1)：

Awards (4)：

2023/10 - On-chip Biotechnologies Award
2023/07 - SBJ East Japan Branch SBJ East Japan Branch Director Award Development of diverse immunosensors through the integration of rapid molecular evolution and in silico structural analysis
2015/09 - 本生物工学会中部支部支部長賞
2013/10 - 日本農芸化学会中部支部企業奨励賞

Association Membership(s) (5)：

日本抗体学会 , 日本生物工学会 , 日本化学工学会 , 生物化学的測定研究会 , 日本酵素工学研究会

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