Zhu Bo

シュハク | Zhu Bo

Affiliation and department：
Job title： Assistant Professor

Research field (4)： Applied biofunctional and bioprocess engineering , Applied biochemistry , Molecular biology , Applied microbiology

Research keywords (6)：高速分子進化 , 合成生物学 , 抗体工学 , 酵素工学 , タンパク質言語モデル , バイオセンサー

Research theme for competitive and other funds (10)：

2024 - 2026 Creatation of antiboy-peptide-nucleic acid conjugates with switch function and its application in a high-sensitive homogeneous detection system
2023 - 2025 将来のパンデミックに備えた迅速対応基盤
2024 - Exploration of microdroplet-based screening methods for rapid engineering of biosensor, bacteria, and functional protein
2023 - 2024 Universal Bio and AI tools for high-throughput engineering of functional proteins
2023 - 2024 Development of hyperstable homogeneous biosensors for virus and cytokine detections

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Papers (23)：

Bo Zhu, Michael D. Lane, Joshua A. Baller, Pratik D. Jagtap, Timothy J. Griffin, Burckhard Seelig. Comprehensive Protease Specificity Profiling. bioRxiv. 2024. 2024.11.06.622033
Akihito Inoue, Bo Zhu, Keisuke Mizutani, Ken Kobayashi, Takanobu Yasuda, Alon Wellner, Chang C. Liu, Tetsuya Kitaguchi. Prediction of singlemutation effects for fluorescent immunosensor engineering with an end-to-end trained protein language model. Jxiv. 2024. Preprint
Cheng Qian, Ayumu Ninomiya, Natsuki Shibukawa, Hiroshi Ueda, Takanobu Yasuda, Bo Zhu, Tetsuya Kitaguchi. Detection of a Large Antigen through the Masking and Exposure of Fragment of Split Luciferase. 2024. Preprint
Yinghui Yang, Akihito Inoue, Takanobu Yasuda, Hiroshi Ueda, Bo Zhu, Tetsuya Kitaguchi. BRET Nano Q-Body: A Nanobody-Based Ratiometric Bioluminescent Immunosensor for Point-of-Care Testing. ACS Sensors. 2024. 9. 11. 5955-5965
Bo Zhu, Yukihiko Yamasaki, Takanobu Yasuda, Cheng Qian, Zhirou Qiu, Mitsue Nagamine, Hiroshi Ueda, Tetsuya Kitaguchi. Customizable OpenGUS immunoassay: a homogeneous detection system using β-glucuronidase switch and label-free antibody. Biosensors and Bioelectronics. 2024. 267. 116796

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MISC (1)：

Alfi Almasul, Zhu Bo, Damnjanovic Jasmina, Kojima Takaaki, Iwasaki Yugo, Nakano Hideo. 3P-024 Expression of the manganese peroxidase from Phanerochaete chrysosporium expressed in chaperone overexpressing Escherichia coli :. 2015. 67. 276-276

Books (2)：

Construction of a DNA library on microbeads using whole genome amplification. In: Kroneis T. (eds) Whole Genome Amplification, Methods in Molecular Biology, vol 1347
Humana Press 2015
切らずに開く酵素スイッチ
日本化学会バイオテクノロジー部ニュースレターVol. 27, No. 2 (2024. 03. 27)

Lectures and oral presentations (10)：

Interaction kinetics analysis of a three-split luciferase-based open sandwich homogeneous immunoassay for mathematical model generation
(The 76th Annual Meeting of the Society of Biotechnology of Japan 2024)
A one-pot detection system using β-glucuronidase-based enzyme switch and label-free antibody
(International Union of Pure and Applied Biophysics (IUPAB) 2024 2024)
A customizable one-pot detection system using β-glucuronidase switch and label-free antibody
(SCEJ 89th Annual Meeting 2024)
Development of diverse immunosensors through rapid molecular evolutions and deep learning
(2024)
Molecular and whole-cell immunosensors developed by directed evolution for applications in diagnostics and food-safety control
(Biotechnology Institute Seminar 2023 Fall, University of Minnesota 2023)

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Education (1)：

Professional career (2)：

Work history (8)：

2024/10 - 現在 Institute of Sciecne Tokyo Laboratory for Chemistry and Life Science, Institute of Integrated Research Assistant professor
2023/03 - 現在 HikariQ Health R&D Manager
2020/05 - 2024/09 Tokyo Institute of Technology Laboratory for Chemistry and Life Science, Institute of Innovative Research Assistant professor
2023/12 - National Yang Ming Chiao Tung University Guest Lecturer
2023/10 - 2023/11 University of California, Los Angeles Visiting scholar

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Committee career (2)：

Awards (6)：

2024/12 - Takeda-rika Award for Young Researcher
2024/06 - 東工大イノベーションデザイン機構(Id機構) 第1回社会変革チャレンジ賞薬物放出制御のためのスイッチ型抗体薬物複合体の創出
2023/10 - On-chip Biotechnologies Award
2023/07 - SBJ East Japan Branch SBJ East Japan Branch Director Award Development of diverse immunosensors through the integration of rapid molecular evolution and in silico structural analysis
2015/09 - 本生物工学会中部支部支部長賞

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Association Membership(s) (5)：

日本抗体学会 , 日本生物工学会 , 日本化学工学会 , 生物化学的測定研究会 , 日本酵素工学研究会

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