Mano Tatsuo

マノタツオ | Mano Tatsuo

Affiliation and department：

Research field (1)： Neurology

Research theme for competitive and other funds (3)：

2022 - 2025 パーキンソン病における慢性脳低灌流のエピジェネティック制御を介した神経保護効果
2019 - 2022 Maintenance of genomic integrity in neuronal cells
2017 - 2019 A novel model for DNA damageaccumulation in Alzheimer's disease

Papers (59)：

Reito Nakamura, Ikumi Tomizawa, Atsushi Iwai, Tetsuo Ikeda, Kota Hirayama, Yung Wen Chiu, Takanobu Suzuki, Airi Tarutani, Tatsuo Mano, Atsushi Iwata, et al. Photo-oxygenation of histidine residue inhibits α-synuclein aggregation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2023. 37. 12. e23311
So Okubo, Tatsuo Mano, Atsushi Sudo, Ryoji Goto, Satoka Yano, Manato Hara, Hiroyuki Ishiura, Wataru Satake, Shintaro Yanagimoto, Hidenori Ogata, et al. Anti-neurofascin 155 Antibody-positive Neuropathy in a Human Immunodeficiency Virus-infected Patient. Internal medicine (Tokyo, Japan). 2023
Naoki Takegami, Akihiko Mitsutake, Tatsuo Mano, Yukako Shintani-Domoto, Atsushi Unuma, Nanaka Yamaguchi-Takegami, Hiroyuki Ishiura, Kaori Sakuishi, Masahiko Ando, Haruo Yamauchi, et al. The Myocardial Accumulation of Aggregated Desmin Protein in a Case of Desminopathy with a de novo DES p.R406W Mutation. Internal medicine (Tokyo, Japan). 2023
Masanori Kurihara, Tatsuo Mano, Fumihiro Eto, Ikuko Yao, Kenichiro Sato, Gaku Ohtomo, Taro Bannai, Shota Shibata, Hiroyuki Ishiura, Masako Ikemura, et al. Proteomic profile of nuclei containing p62-positive inclusions in a patient with neuronal intranuclear inclusion disease. Neurobiology of disease. 2023. 177. 105989-105989
Kenichiro Sato, Yoshiki Niimi, Tatsuo Mano, Atsushi Iwata, Takeshi Iwatsubo. Time to onset of drug-induced parkinsonism: Analysis using a large Japanese adverse event self-reporting database. Bioscience trends. 2022. 16. 2. 151-157

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MISC (108)：

間野達雄, 岩田淳. 【アルツハイマー病-研究と治療の最前線】基礎エピジェネティクスとアルツハイマー病. 医学のあゆみ. 2023. 287. 13. 916-920
間野達雄, 大友岳, 橋本唯史, 戸田達史, 岩田淳. Hif1aとα-Syn分解パーキンソン病における神経細胞特異的エピゲノム(Hif1a and α-Syn Degradation: A Neuron-Specific Epigenome in Parkinson's Disease). Dementia Japan. 2023. 37. 4. 708-708
中村悠弥子, 木村友彦, 角元利行, 松川敬志, 阿部浩幸, 間野達雄, 濱田雅, 戸田達史. GFAP遺伝子にヘテロ接合性のp.A364T変異を認めた成人型Alexander病の1家系の検討. 臨床神経学. 2023. 63. Suppl. S274-S274
中村悠弥子, 木村友彦, 角元利行, 松川敬志, 阿部浩幸, 間野達雄, 濱田雅, 戸田達史. GFAP遺伝子にヘテロ接合性のp.A364T変異を認めた成人型Alexander病の1家系の検討. 臨床神経学. 2023. 63. Suppl. S274-S274
富澤郁美, Chiu Yung-Wen, 間野達雄, 小野麻衣子, 樋口真人, 戸田達史, 岩田淳, 堀由起子, 富田泰輔. 疾患由来線維を用いた構造選択的αシヌクレイン細胞内線維形成制御因子の同定. 老年精神医学雑誌. 2022. 33. 増刊II. 218-218

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Education (3)：

2012 - 2016 The University of Tokyo Graduate School of Medicine Neuroscience
2003 - 2007 The University of Tokyo Faculty of Medicine School of Medicine
2001 - 2003 The University of Tokyo College of Arts and Sciences

Professional career (1)：

医学博士 (東京大学)

Work history (7)：

2022/04 - 現在 National Center of Neurology and Psychiatry
2018/01 - 2022/03 The University of Tokyo Hospital Department of Neurology
2016/04 - 2017/12 The University of Tokyo Hospital Department of Neurology
2011/04 - 2012/03 横浜労災病院神経内科後期研修医
2010/10 - 2011/03 NTT東日本関東病院神経内科後期研修医

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Awards (6)：

2019/12 - 長寿科学振興財団長寿科学賞 Alzheimer病剖検脳の神経細胞特異的メチル化解析から明らかになった,神経変性におけるDNA傷害蓄積の重要性
2019/12 - 先進医薬研究振興財団精神薬療分野研究助成アルツハイマー病における活動依存性DNA2重鎖切断とその代償機構の解明
2018/11 - 持田記念医学薬学振興財団持田記念研究助成金神経細胞におけるゲノムDNA 恒常性維持機構の分子メカニズムに対する探索的アプローチ
2018/11 - Takeda Science Foundation Research grant for medical science
2018/04 - Japan foundation for aging and health Travel grand award Tau-related dysfunction of BRCA1 lead to reduced neuronal plasticity in Alzheimer’s disease

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