Research field (2)：
Immunology
, Oral medicine (pathology)
Research keywords (5)：
immunometabolism
, tissue resident macrophage
, Persistent symbiotic colonization of tissue resident macrophages with commensal bacteria
, Innate inflammation in the intestinal mucosa
, Mucosal Immunity
Research theme for competitive and other funds (29)：
2024 - 2027 微生物細胞内共生現象の分子機構の生体エネルギー論的展開
2019 - 2023 微生物・細胞内共生現象の解明とその破綻に起因する日和見感染発症機構の解析
2016 - 2018 腸管免疫統合的制御による炎症性腸疾患新規予防・治療戦略研究開発
2015 - 2016 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築
2012 - 2016 炎症性腸疾患の慢性化制御機構の解明と治療戦略の基盤構築
2009 - 2010 イネ発現系を利用した新規ヒト型抗う蝕予防抗体の開発と応用
2004 - 2005 食性抗原に対する粘膜免疫作動機構の解明
2004 - 2005 A novel mucosal immunomodulator MICA for homeostasis of the mucosal immune system
2003 - 2004 新規粘膜免疫システム制禦分子MICAの免疫作動機構の解明と応用技術の開発
2002 - 2003 胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析
2002 - 2003 免疫システムの構築・作動の分子機構とその制御技術の開発
2001 - 2002 胸腺外分化T細胞の生理的リガンドの探索と感染防御における病因論的役割の解析
2000 - 2001 Molecular biology of extrathymic T cells for the development of mucosal inflammation
1998 - 2000 Characterization of Novel Mucosal Modulator for IgA
1997 - 2000 Characterization of mucosal intranet formed by γδ/αβ T cells and epithelial cells
1998 - 1999 Molecular biology of oligoclonal ββT cells in murine inflammatory bowel disease
1998 - 1999 A study of the environmental factors for the development of inflammatory bowel disease
1996 - 1997 T細胞受容体欠損マウスを用いた経口免疫寛容の分子メカニズムの解明
1996 - 1997 Mucosal Vaccines : Vectors and Adjuvants for Novel Th1 and Th2 cells
1995 - 1996 細胞感染に起因する粘膜免疫の細胞生物学的研究
1994 - 1996 Development of mutacin MT6223 from Streptococcus sobrinus as an anti-caries agent
1994 - 1995 粘膜免疫誘導エピトープのマッピング
1993 - 1995 Bacterial endotoxic substances from periodontopathic bacteria and their effects on host cells
1992 - 1993 う蝕原性細菌のシグナル伝達系2成分制御蛋白質の遺伝子クローニング
1991 - 1992 MHC非拘束性合成う蝕ワクチンの研究
1990 - 1991 蛋白質工学を利用した蝕ワクチンの分子設計
1989 - 1990 合成ペプチドを用いたう蝕ワクチンの開発
1989 - 1990 蛋白質工学を利用したう蝕ワクチンの開発
1988 - 1990 Development of Anti-Dental Caries Vaccine Using Recombinant Lactic Streptococci
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Papers (77)：
Shunryou Yanagisawa, Karin Nagasaki, Chanbora Chea, Toshinori Ando, Nurina Febriyanti Ayuningtyas, Toshihiro Inubushi, Atsushi Ishikado, Hiromichi Imanaka, Eiji Sugiyama, Ichiro Takahashi, et al. Oral administration of bovine lactoferrin suppresses the progression of rheumatoid arthritis in an SKG mouse model. PLOS ONE. 2022. 17. 2. e0263254-e0263254
Takahashi I, Hosomi K, Nagatake T, Toubou H, Yamamoto D, Hayashi I, Kurashima Y, Sato S, Shibata N, Goto Y, et al. Persistent colonization of non-lymphoid tissue-resident macrophages by Stenotrophomonas maltophilia. Int Immunol. 2020. 32. 2. 133-141
T. Ogita, J. Miyamoto, Y. Hirabayashi, M. Rossi, G. Mazzarella, I. Takahashi, S. Tanabe, T. Suzuki. Analysis of hypoxia-associated dendritic cells in colitic mice and effects of probiotics on IL-10 production in inflammatory dendritic-cells under hypoxia. Beneficial Microbes. 2019. 10. 7. 801-810
