Hara Masatoshi

Affiliation and department：

Research field (1)： Molecular biology

Research theme for competitive and other funds (5)：

2024 - 2027 初期胚発生におけるセントロメア機能を維持する分子機構
2022 - 2024 卵賦活化が引き起こす母性mRNA翻訳調節による全能性獲得機構の解明
2021 - 2024 セントロメアクロマチンの”コンパクトさ”を形作る機構とその意義
2020 - 2022 Regulatory mechanisms of maternal mRNAs translation during egg activation
2016 - 2018 Regulatory mechanisms of cell cycle-dependent switching of protein interaction network in vertebrate kinetochore

Papers (27)：

Weixia Kong, Masatoshi Hara, Yurika Tokunaga, Kazuhiro Okumura, Yasuhiro Hirano, Jiahang Miao, Yusuke Takenoshita, Masakazu Hashimoto, Hiroshi Sasaki, Toshihiko Fujimori, et al. CENP-C-Mis12 complex establishes a regulatory loop through Aurora B for chromosome segregation. Life Science Alliance. 2024. 8. 1. e202402927-e202402927
Masatoshi Hara, Mariko Ariyoshi, Tomoki Sano, Ryu-Suke Nozawa, Soya Shinkai, Shuichi Onami, Isabelle Jansen, Toru Hirota, Tatsuo Fukagawa. Centromere/kinetochore is assembled through CENP-C oligomerization. Molecular Cell. 2023. 83. 13. 2188-2205.e13
Yusuke Takenoshita, Masatoshi Hara, Tatsuo Fukagawa. Recruitment of two Ndc80 complexes via the CENP-T pathway is sufficient for kinetochore functions. Nature communications. 2022. 13. 1. 851-851
Reito Watanabe, Yasuhiro Hirano, Masatoshi Hara, Yasushi Hiraoka, Tatsuo Fukagawa. Mobility of kinetochore proteins measured by FRAP analysis in living cells. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2022
Emir E Avilés-Pagán, Masatoshi Hara, Terry L Orr-Weaver. The GNU subunit of PNG kinase, the developmental regulator of mRNA translation, binds BIC-C to localize to RNP granules. eLife. 2021. 10

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MISC (5)：

Lectures and oral presentations (25)：

CENP-C-Mis12 Complex Interaction Establishes a Positive Feedback Loop Through Aurora B Recruitment for Accurate Chromosome Segregation in Mammalian Cells
(The 2024 Centromere Biology Gordon Research Conference 2024)
マウスを用いたCENP-C機能ドメイン解析
(第41 回染色体ワークショップ・第22 回核ダイナミクス研究会 2024)
ショウジョウバエ卵賦活化における母性mRNA翻訳調節
(全能性プログラム:デコーディングからデザインへ Epigenome Dynamics and Regulation in Germ Cells 第5回公開シンポジウム 2023)
正確な染色体分配を支える分子基盤
(第2回細胞分裂研究会 2023)
セントロメアタンパク質CENP-Cの多量体化によるセントロメアクロマチン構造制御
(第16回日本エピジェネティクス研究会 2023)

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Education (2)：

2000 - 2007 Tokyo Institute of Technology Graduate School of Life Science and Technology
1996 - 2000 Tokyo Institute of Technology Department of Life Science and Technology

Professional career (1)：

Work history (5)：

2015/07 - 現在 Osaka University Graduate School of Frontier Biosciences Assistant Professor
2011/09 - 2015/06 Whitehead Institute of Biomedical Research Postdoc
2011/09 - 2013/08 Whitehead Institute of Biomedical Research JSPS Postdoc fellow
2009/07 - 2011/08 Tokyo Institute of Technology Graduate School of Life Science and Technology Postdoc
2007/10 - 2009/06 Tokyo Institute of Technology Graduate School of Life Science and Technology Research and Teaching Assistant

Awards (12)：

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