Research field (3)：
Pharmacology
, Tumor biology
, Veterinary medicine
Research keywords (4)：
Veterinary Medicine
, Cell Biology
, Cancer
, Protein Phosphatase
Research theme for competitive and other funds (8)：
2022 - 2024 メチオニン代謝のリン酸化シグナルへの変換に着目したNASH発症機構の解明
2020 - 2023 Stemness as a target for anti-cancer drug development
2017 - 2020 Development of novel anti-cancer strategy targeting protein phosphatases
2015 - 2017 Clarification of the role of myofibroblasts in cancer niche by development of cancer-tissue like organoid
2013 - 2015 Mechanism of turnout switch for cell death
2010 - 2012 The expression mechanism of protease activated receptors with inflammatory stimulations in intestinal myofibroblasts.
2006 - 2008 Prostaglandin D2-mediated control mechanisms of natural immunity and gastrointestinal dysfunction
2005 - 2006 慢性腸炎時における消化管運動機能傷害の分子機序
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Papers (61)：
Naoki Kohyanagi, Nao Kitamura, Shunta Ikeda, Shusaku Shibutani, Koichi Sato, Takashi Ohama. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. The Journal of biological chemistry. 2023. 105584-105584
Nao Kitamura, Takashi Ohama, Koichi Sato. Protein phosphatase 6 promotes transforming growth factor-β signaling in mouse embryonic fibroblasts. The Journal of veterinary medical science. 2023. 85. 12. 1319-1323
Naoki Kohyanagi, Nao Kitamura, Shunta Ikeda, Shusaku Shibutani, Koichi Sato, Takashi Ohama. PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt activation and maintains the colony-formation ability of cancer cells. Journal of Biological Chemistry. 2023. 105584-105584
Shunta Ikeda, Koichi Sato, Takashi Ohama. Transcriptome analysis revealed that PME-1 suppresses inflammatory signaling, activates PI3K/Akt signaling, and promotes epithelial-mesenchymal transition. Biochemical and biophysical research communications. 2023. 692. 149148-149148
Sana Ando, Masashi Sakurai, Shusaku Shibutani, Nobuyuki Kimura, Nobuhiro Shimozawa, Yasuhiro Yasutomi, Ryotaro Yabe, Takashi Ohama, Koichi Sato. Age-related alterations in protein phosphatase 2A methylation levels in brains of cynomolgus monkeys: a pilot study. Journal of biochemistry. 2023
THE JAPANESE PHARMACOLOGICAL SOCIETY
, THE JAPANESE CANCER ASSOCIATION
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY OF VETERINARY SCIENCE
