Zou Kun

Research field (1)： Neuropathology

Research theme for competitive and other funds (7)：

2023 - 2026 Elucidation of novel functions of presenilin in ApoE secretion and brain amyloid removal
2022 - 2026 Role of Abeta-converting activity in the pathogenesis of familial Alzheimer's disease
2019 - 2023 Role of renin-angiotensin system in regulation of brain amyloid deposition
2014 - 2017 Regulation of brian amyloid deposition by angiotensin receptor type Ia
2012 - 2014 Abeta43-converting enzyme and its role in amyloid deposition

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Papers (68)：

Yang Sun, Sadequl Islam, Yuan Gao, Tomohisa Nakamura, Taisuke Tomita, Makoto Michikawa, Kun Zou. Presenilin deficiency enhances tau phosphorylation and its secretion. Journal of neurochemistry. 2024. 168. 9. 2956-2973
Yang Sun, Sadequl Islam, Makoto Michikawa, Kun Zou. Presenilin: A Multi-Functional Molecule in the Pathogenesis of Alzheimer's Disease and Other Neurodegenerative Diseases. International journal of molecular sciences. 2024. 25. 3
Yuan Gao, Yang Sun, Sadequl Islam, Tomohisa Nakamura, Taisuke Tomita, Kun Zou, Makoto Michikawa. Presenilin 1 deficiency impairs Aβ42-to-Aβ40- and angiotensin-converting activities of ACE. Frontiers in Aging Neuroscience. 2023. 15. 1098034-1098034
Tomohisa Nakamura, Tadahiro Hashita, Yuxin Chen, Yuan Gao, Yang Sun, Sadequl Islam, Hiroyuki Sato, Yasuyuki Shibuya, Kun Zou, Tamihide Matsunaga, et al. Aβ42 treatment of the brain side reduced the level of flotillin from endothelial cells on the blood side via FGF-2 signaling in a blood-brain barrier model. Molecular brain. 2023. 16. 1. 15-15
Yang Sun, Sadequl Islam, Yuan Gao, Tomohisa Nakamura, Kun Zou, Makoto Michikawa. Apolipoprotein E4 inhibits γ-secretase activity via binding to the γ-secretase complex. Journal of neurochemistry. 2022. 164. 6. 858-874

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MISC (41)：

鄒鶤, 高原, 孫陽, イスラムサデクル, 中村知寿, 富田泰輔, 道川誠. プレセニリン1欠損/変異はACEのAβ42変換活性を阻害する. 日本生化学会大会(Web). 2023. 96th
鄒鶤, 道川誠. ニューロサイエンスの最新情報アルツハイマー病におけるプレセニリンの役割. Clinical Neuroscience. 2022. 40. 10. 1320-1322
高原, 孫陽, SADEQUL Islam, 中村知寿, 富田泰輔, 鄒鶤, 道川誠. プレセニリン1欠損がACEのAβ変換活性に及ぼす影響. 日本神経化学会大会抄録集(Web). 2022. 65th
藤田融, 岸野重信, 可野邦行, 鄒鶤, 鈴木利治, 駒野宏人. アルツハイマー病におけるCis型共役リノール酸摂取の効果. 日本薬学会関東支部大会講演要旨集. 2022. 66th (CD-ROM)
イスラムサデクル, 孫陽, 高原, 中村知寿, ARSHAD Ali Noorani, 木村成志, 松原悦郎, 春日健作, 池内健, 富田泰輔, et al. プレセニリンはApoEの分泌に必須である. Dementia Japan. 2022. 36. 4

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Books (1)：

Handbook on longevity : genetics, diet and disease
Nova Biomedical Books ISBN:9781607410751

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