Aoyama Eriko

アオヤマエリコ | Aoyama Eriko

Research field (1)： Oral medicine

Research keywords (4)：生化学 , 骨代謝 , biological chmistry , bone metabolism

Research theme for competitive and other funds (40)：

2023 - 2027 Development of dropletomics that clarifies transcriptional regulation under liquid-liquid phase separation
2023 - 2026 Intracellular proteostatic function of CCN2 in chondrocytes during endochondral ossification
2022 - 2025 S-アデノシルメチオニンによる軟骨基質産生の新制御機構の解明-ポリアミンを中心に
2022 - 2025 象牙芽細胞の表面に突き出た細胞小器官の機能解析と象牙質再生への応用
2021 - 2025 Regulation of skeletogenesis by long noncoding RNAs through CCN2

2021 - 2024 Inverse genetics: A new methodology for the identification of key genes of somatic cell differentiation

2020 - 2024 Pioneering chondroneutrigenomics research and its development into chondroneutrigenetics

2020 - 2023 CCN2の転写因子様機能を介した線維症のキープレイヤー筋線維芽細胞分化機構の解明

2020 - 2023 三次元腫瘍オルガノイド評価系により見出された新規癌転移抑制化合物の創薬展開

2019 - 2023 Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular base

2019 - 2022 CD302の新機能:破骨細胞の分化制御とその機構及び骨・軟骨代謝研究への展開

2019 - 2022 細胞アンテナによる象牙質再生への道を拓く基礎研究

2018 - 2022 The study of the regulatory mechanisms of cancer bone destruction metabolism and immunity in Hedgehog signaling

2019 - 2021 Regulation of CCN2 by an endogenous UTR blocker and its biological significance

2017 - 2020 Neutrigenomics studies on endochondral ossification and articular cartilage mainteinance/regeneration

2017 - 2020 Mechanism of onset of osteoarthritis caused by obesity and regulatory effects of CCN2

2016 - 2020 The investigation of the mechanism of regular arrangement of odontoblasts via extracellular environment sensing sensors

2017 - 2019 Novel regulatory mechanism of endochondral ossification via CCN2-VASH1 axis

2017 - 2019 New potential of CCN2: Functional evaluation as a Warburg effector

2016 - 2019 Roles of CCN2 and Rab14 in the formation of extracellular matrix

2015 - 2018 Establishment of molecular basis of CCN family proteins for therapeutic use and its related translational research

2015 - 2018 Mechanism and expression of CD302 as a new regulator of osteoclast maturation

2015 - 2018 Analysis of the CTGF/CCN2 expression promotion system which classified cartilage regenerative therapy into the field

2014 - 2017 Effect of CCN2 on the osteocyte function regulating the osteoclast formation, and its possibility as a novel drug of osteoporosis

2014 - 2016 The presence and its significance of non-canonical action of decoy receptors

2013 - 2016 Investigation on the biological diarchy by CCN2 and CCN3 for integrated tissue development

2013 - 2016 Novel function of CCN3: A regulator of endochondral ossification

2013 - 2015 New regulatory system of RANK signaling via the binding of CCN2 and OPG

2012 - 2015 Elucidation of molecular basis of CCN family action as masterminds and its medical application

2011 - 2013 Functional analysis of CCN2 as a metabolic supporter and potential clinical applications in chondrocyte regeneration

2011 - 2013 Analysis of molecular mechanism of muscle heterotopic ossification by forming a network with CCN family proteins

2011 - 2012 A new protein transport system in cartilage: Multilayered transcytosis

2010 - 2011 The analysis of binding of CTGF/CCN2 to RANK and its effects on RANK/RANKL signaling

2009 - 2011 Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder

2009 - 2011 Development and medical application of peptide and RNA aptamers that bind to CCN2

2007 - 2011 Comprehensive study on molecular basis of actions of CCN family proteins as novel signal conductors and its translational application

2007 - 2008 Analysis of the role of cartilage-specific gene in endochondral bone formation using BAC (bacterial artificial chromosome)-transgenic mice

2007 - 2008 MMPの新機能:マトリクス合成促進因子の転写因子としての役割

2005 - 2006 Role of CCN2 as a trans-modulator in the integrated development of bone, cartilage and hematopoietic systems

2003 - 2006 The role of CTGF as a novel tissue-regenerating factor, regenerin, and its application for medical and dental tissue engineering

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Papers (74)：

Loc Dinh Hoang, Eriko Aoyama, Miki Hiasa, Hiroshi Omote, Satoshi Kubota, Takuo Kuboki, Masaharu Takigawa. Positive Regulation of S-Adenosylmethionine on Chondrocytic Differentiation via Stimulation of Polyamine Production and the Gene Expression of Chondrogenic Differentiation Factors. International Journal of Molecular Sciences. 2023. 24. 24. 17294-17294
Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Toshifumi Ozaki, Masaharu Takigawa. The Evaluation of Meniscus Regenerative Effects 2 of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 3 and Meniscus-Related Genes in Cultured Meniscus Cells 4 and Meniscus Tissues. Methods in Molecular Biology. 2023. 2582. 223-235
Eriko Aoyama, Masaharu Takigawa. Evaluation of the Molecular Interaction Between CCN 2 Protein and Its Binding Partners: A Solid-Phase Binding 3 Assay and Surface Plasmon Resonance. Methods in Molecular Biology. 2023. 2582. 77-86
Mitsuhiro Hoshijima, Eriko Aoyama, Hiroshi Kamioka, Masaharu Takigawa. Imaging of Molecular Interaction Between CCN Protein 2 and Its Binding Partners: An In Situ Proximity Ligation 3 Assay of Interaction Between CCN2 and Rab14 4 in Chondrocytes. Methods in Molecular Biology. 2023. 2582. 31-37
ホアンディン・ロック, 青山絵理子, 久保田聡, 窪木拓男, 滝川正春. S-アデノシルメチオニンはポリアミン産生だけでなく増殖因子の遺伝子発現を促進することによって軟骨分化を促進する(S-adenosylmethionine induces chondrocytic differentiation not only as source of polyamine production but also by stimulating growth factor genes expression). Journal of Oral Biosciences Supplement. 2022. 2022. 134-134

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MISC (92)：

LOC Hoangdinh, LOC Hoangdinh, 青山絵理子, 日浅未来, 表弘志, 久保田聡, 窪木拓男, 滝川正春. S-adenosylmethionine promotes chondrocyte differentiation via polyamine synthesis and gene expression of growth factors. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
東原直裕, 東原直裕, 東原直裕, 青山絵理子, 古松毅之, 久保田聡, 尾崎敏文, 滝川正春. The effects of binding of CCN2 to GDF5 and its receptors on chondrocytes. 日本軟骨代謝学会プログラム・抄録集. 2023. 35th
東原直裕, 東原直裕, 青山絵理子, 古松毅之, 久保田聡, 尾崎敏文, 滝川正春. GDF5およびその受容体との結合を介したCCN2の軟骨細胞分化制御機構. 日本整形外科学会雑誌. 2023. 97. 8
河田かずみ, 青山絵理子, 滝川正春, 久保田聡. Intraflagellar transport protein88によるHippo経路と古典的WNT経路を介した象牙芽前駆細胞増殖制御の可能性. Journal of Oral Biosciences Supplement (Web). 2023. 2023
東原直裕, 東原直裕, 青山絵理子, 古松毅之, 久保田聡, 尾崎敏文, 滝川正春. Physiological significance of binding of GDF5 and CCN2 on chondrocytes. 日本軟骨代謝学会プログラム・抄録集. 2022. 34th

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Education (2)：

- 2005 Okayama University
- 2005 Okayama University Graduate School, Division of National Science and Technology

Professional career (1)：

Doctor (Pharmacy) (Okayama University)

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