Rchr
J-GLOBAL ID：201801019049457341   Update date: Feb. 17, 2024

Hiroki Sakai

サカイ ヒロキ | Hiroki Sakai
Research field  (4)： Forensic medicine ,  Environmental effects of chemicals ,  Environmental effects of radiation ,  Pharmacology
Research keywords  (11)： マクロファージ ,  関節リウマチ ,  法医学 ,  Peptide ,  環境汚染 ,  aptamer ,  Heart Failure ,  Nuclear receptor ,  Pharmacology ,  Wound healing ,  Environmental toxicology
Research theme for competitive and other funds  (11)：
  • 2021 - 2024 PDZRN3による核内のパラスペックルを介した新たな心筋分化制御機構の解明
  • 2019 - 2022 Mechanism of promoting wound healing by the coordinated action of growth factors and neurotrophic factors
  • 2018 - 2021 Development of Novel Cyclic Peptide Drugs Targeting Phospholamban for the Treatment of Heart Failure
  • 2017 - 2020 Ultrastructural analysis of calcium transport system of cardiac sarcoplasmic reticulum for drug development
  • 2016 - 2019 Elucidation of the molecular mechanisms by a cyclic peptide, SEK-1005 promotes skin wound healing
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Papers (15)：
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MISC (50)：
  • 中川 碧, 姫宮 彩子, 酒井 大樹, 重本 亜純, 高瀬 泉. 山口県の水中発見事例におけるプランクトン検査を行った12剖検例. 山口医学. 2022. 71. 2-3. 96-96
  • 竹入 雅敏, 常陰 幸乃, 森谷 歩香, 新井 啓子, 酒井 大樹, 朝霧 成挙, 木村 吉秀. JAK阻害活性を持つ植物抽出物の同定. 日本薬学会年会要旨集. 2022. 142年会. 27PO5-05
  • Hina Takegami, Nakamura Hiyori, Takeda Ayano, Matsuo Mayu, Sakai Hiroki, Honda Takeshi, Asagiri Masataka. Synthetic retinoid bexarotene inhibits differentiation of inflammatory osteoclasts. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-P-248
  • Seiya Tanaka, Okamoto Asuka, Tsubaki Honoka, Seto Tetsuya, Sakai Hiroki, Honda Takeshi, Asagiri Masataka. Inhibitory effect of spermidine on differentiation of inflammatory osteoclasts. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-P-249
  • Ishida Chika, Suzuki Miren, Seto Tetsuya, Otsuka Marina, Sakai Hiroki, Takeiri Masatoshi, Tsunekage Yukino, Arai Keiko, Honda Takeshi, Kimura Yoshihide, et al. Suppression of M1 macrophage activation and osteoclast differentiation by Apocynaceae plant extract. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 95. 3-P-164
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Patents (1)：
Lectures and oral presentations  (4)：
  • Molecular characterization of Baikal seal CYP2B/3A promoter/enhancer regions and their transactivation potencies by POPs.
    (5th SETAC World Congress 2008)
  • Transactivation potentials of constitutive androstane/active receptor by persistent organic pollutants and brominated flame retardants: A comparative study of Baikal seal (Pusa sibirica) and mouse.
    (27th International Symposium on Halogenated Environmental Organic Pollutants and POPs 2007)
  • Specific ligand profile of constitutive androstane receptor (CAR) in Baikal seal (Pusa sibirica): Toward the risk assessment of non-dioxin-like chemicals.
    (25th International Symposium on Halogenated Environmental Organic Pollutants and POPs 2005)
  • Molecular and functional characteristics of constitutive androstane receptor in an aquatic mammal, Baikal seal (Pusa sibirica)
    (7th International Symposium on Cytochrome P450 Biodiversity and Biotechnology 2004)
Education (2)：
  • 2004 - 2007 The United Graduate School of Agricultural Science, Ehime University
  • 2001 - 2003 Graduate School of Agriculture, Ehime University
Professional career (1)：
  • 博士(農学) (愛媛大学)
Work history (5)：
  • 2022/04 - 現在 山口大学大学院医学系研究科 法医学 講師(特命)
  • 2012/04 - 2022/03 Yamaguchi University Graduate School of Medicine Department of Pharmacology Research associate
  • 2010/05 - 2012/03 Yamaguchi University Graduate School of Medicine Department of Pharmacology Researcher
  • 2008/08 - 2010/04 Department of Chemistry, Faculty and Graduate School of Science, Kyushu University Laboratory of Structure-Function Biochemistry Researcher
  • 2007/03 - 2008/07 Center for Marine Environmental Studies, Ehime University Researcher
Committee career (2)：
  • 2022/09 - 現在 日本薬理学会 代議員
  • 2020/04 - 現在 日本薬理学会 学術評議員
Awards (3)：
  • 2021/11 - 山口大学大学院医学系研究科 令和3年度革新的研究の発掘と育成プロジェクト(FOCSプロジェクト)研究奨励賞 放線菌由来環状ペプチドSEK-1005をプローブとした創傷治癒創薬ターゲットの探索
  • 2012/08 - 山口大学医学会 学術講演会奨励賞 インスリン様成長因子-1 Cドメイン由来のテトラペプチドSSSRによる単一HaCat細胞の遊走促進作用
  • 2004/08 - 7th International Symposium on Cytochrome P-450 Biodiversity and Biotechnology 優秀ポスター賞
Association Membership(s) (4)：
日本法医学会 ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  Japan Society of Endocrine Disrupter Research ,  THE JAPANESE PHARMACOLOGICAL SOCIETY
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