Rchr
J-GLOBAL ID:201801019097795313   Update date: Jan. 17, 2024

Masayuki Nashimoto

ナシモト マサユキ | Masayuki Nashimoto
Affiliation and department:
Job title: Professor
Homepage URL  (1): http://www2.nupals.ac.jp/kenkoujiritsu/?_ga=2.254999887.693138533.1608213791-1459970760.1595247899
Research field  (8): Medical biochemistry ,  Virology ,  Hematology and oncology ,  Evolutionary biology ,  Pharmaceuticals - chemistry and drug development ,  Molecular biology ,  Cell biology ,  Tumor diagnostics and therapeutics
Research keywords  (28): biomarker ,  31/32-nt Y4-RNA fragment ,  5'-half-tRNA ,  COVID-19 ,  SARS-CoV-2 ,  macrophage ,  tumor microenvironment ,  hematological malignancies ,  multiple myeloma ,  tRNase Z ,  sgRNA ,  TRUE gene silencing ,  gene regulation ,  oligonucleotide therapeutics ,  RNATherapeutics ,  tumor microenvironment ,  バイオマーカー ,  マクロファージ ,  31/32-nt Y4-RNA fragment ,  SARS-CoV-2 ,  multiple myeloma ,  tRNase Z ,  gene regulation、TRUE gene silencing、sgRNA ,  5'-half-tRNA ,  造血器腫瘍 ,  核酸医薬 ,  RNA Therapeutics ,  RNA治療学
Research theme for competitive and other funds  (40):
  • 2022 - 2023 多発性骨髄腫治療用sgRNA薬候補の作用機構の解明
  • 2022 - AI技術を用いた膜透過性アプタマーの機能最適化と網羅的薬効評価法の確立
  • 2021 - 2022 医療応用に向けたWOWエマルション簡易作成デバイスの開発
  • 2020 - 2022 ヒト乳がん細胞にアポトーシスを誘導するIRDAptamerのin vivo試験
  • 2019 - 2022 メタロβ-ラクタマーゼの未知酵素活性の検証と新規アプローチによる阻害剤探索
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Papers (73):
  • Mineaki Seki, Akihiko Komuro, Tatsuya Ishikawa, Masayuki Takahashi, Masayuki Nashimoto. Genes for tRNA recycling are upregulated in response to infection with Theiler's mouse encephalitis virus. Biochemical and Biophysical Research Communications. 2022. 587. 63-68
  • Mineaki Seki, Akihiko Komuro, Masayuki Takahashi, Masayuki Nashimoto. Transcription from the proximal promoter of ELAC1, a gene for tRNA repair, is upregulated by interferons. Biochemical and Biophysical Research Communications. 2021. 585. 162-168
  • HIRONOBU YANAGIE, MASASHI YANAGAWA, YASUYUKI MORISHITA, ATSUKO SHINOHARA, NOVRIANA DEWI, YASUMASA NONAKA, YOSHITAKA FURUYA, RYOUJI MIZUMACHI, YUUJI MURATA, HIROYUKI NAKAMURA, et al. Suppression of Tumor Growth in a Rabbit Hepatic Cancer Model by Boron Neutron Capture Therapy With Liposomal Boron Delivery Systems. In Vivo. 2021. 35. 3125-3135
  • Masayuki Takahashi, Mineaki Seki, Masayuki Nashimoto, and Tomohiro Kabuta. Perturbing the Normal Level of SIDT1 Suppresses the Naked ASO Effect. Journal of Nucleic Acids. 2021. 2021
  • Masayuki Takahashi, Mineaki Seki, Masayuki Nashimoto. A naked antisense oligonucleotide with phosphorothioate linkages is taken up intracellularly more efficiently but functions less effectively. Biochemical and Biophysical Research Communications. 2021. 573. 140-144
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MISC (47):
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Patents (4):
  • HEPTAMER-TYPE SMALL GUIDE NUCEIC ACIDS INDUCING APOPTOSIS OF HUMAN LEUKEMIA CELLS
  • ヒト白血病細胞のアポトーシスを誘導するヘプタマー型スモールガイド核酸
  • ヒト血液がん細胞のアポトーシスを誘導するヘプタマー型スモールガイド核酸
  • RNA切断方法並びにそれに用いられるリボヌクレア-ゼ
Books (2):
  • Biochemistry (4th Edition) by Christopher K. Mathews,‎ Kensal E. van Holde,‎ Dean R. Appling, Spencer J. Anthony-Cahill
    2015
  • Biochemistry (3rd Edition) by Christopher K. Mathews,‎ Kensal E. van Holde,‎ Kevin G. Ahern
    2003
Lectures and oral presentations  (64):
  • 環境DNA情報の秘めた可能性
    (2022)
  • 環境DNA情報の秘めた可能性
    (令和4年度 冬季トップライズグループ講演会 2022)
  • ヒトOCT4 mRNAを標的とするheptamer型sgRNAはOCT4の発現を上昇させることができる
    (第26回バイオ治療法学会学術集会 2022)
  • IMP-27の機能・構造解析: IMP型β-ラクタマーゼの分子進化
    (第62回新潟生化学懇話会 2022)
  • SIDT1の発現レベル変化によるASOの効果抑制について
    (第44回日本分子生物学会年会 2021)
more...
Education (3):
  • 1986 - 1990 Niigata University Graduate School, Division of Medicine
  • 1984 - 1986 Tokyo University of Science
  • 1979 - 1984 Tokyo University of Science Faculty of Science and Engineering
Professional career (2):
  • 理工学 (東京理科大学)
  • 医学 (新潟大学)
Work history (19):
  • 2014/10 - 2023/03 Niigata University of Pharmacy and Applied Life Sciences Professor
  • 2015/04 - 2017/03 Lecturer
  • 2007/04/01 - 2014/09/30 Niigata University of Pharmacy and Applied Life Sciences Faculty of Applied Life Sciences
  • 2007/04 - 2014/09 Niigata University of Pharmacy and Applied Life Sciences Faculty of Applied Life Sciences Department of Applied Life Sciences Professor
  • 2011/04 - 2012/03 Lecturer
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Awards (1):
  • 1997/10 - The RNA Society of North Carolina Young Investigator Participation Award (Symposium on RNA Biology II: Tool and Target)
Association Membership(s) (8):
日本分子生物学会 ,  日本生化学会 ,  日本癌学会 ,  日本RNA学会 ,  新潟生化学懇話会 ,  バイオ治療法研究会 ,  RNA Society ,  Oligonucleotide Therapeutics Society
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