Research theme for competitive and other funds (7):
2023 - 2026 Mechanisms of reciprocal regulation of immune diseases by EBI3-containing heterodimer cytokines
2019 - 2022 The investigation of the pathogenesis of TNF receptor-associated periodic syndrome
2019 - 2022 A novel regulatory mechanism for innate immune signals by ectoenzymes BST-1 and CD38
2018 - 2021 The role of SH3BP2 in the pathogenesis of systemic lupus eryhematosus
2017 - 2021 Roles for CD157 in functions of macrophage lineage cells and early pathophysiology of a rheumatoid arthritis model
2015 - 2018 Activation machinery of tissue-resident innate IL-5-producing cells and their roles in inflammatory diseases and fibrosis
2009 - 2011 Analysis of the pathogenic mechanisms of autoimmune diseases induced by overproduction of cytokine TSLP
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Papers (27):
Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai. Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model. Frontiers in immunology. 2023. 14. 1214623-1214623
Takahiko Akagi, Sumie Hiramatsu-Asano, Kenta Ikeda, Hiroyasu Hirano, Shoko Tsuji, Ayano Yahagi, Masanori Iseki, Makoto Matsuyama, Tak W. Mak, Kazuhisa Nakano, et al. TRAPS mutations in Tnfrsf1a decrease the responsiveness to TNFα via reduced cell surface expression of TNFR1. Frontiers in Immunology. 2022. 13
Kenta Ikeda, Shin Morizane, Takahiko Akagi, Sumie Hiramatsu-Asano, Kota Tachibana, Ayano Yahagi, Masanori Iseki, Hideaki Kaneto, Jun Wada, Katsuhiko Ishihara, et al. Obesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation. International journal of molecular sciences. 2022. 23. 8
Tomoyuki Mukai, Takahiko Akagi, Sumie Hiramatsu Asano, Ikue Tosa, Mitsuaki Ono, Mizuho Kittaka, Yasuyoshi Ueki, Ayano Yahagi, Masanori Iseki, Toshitaka Oohashi, et al. Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model. Oral diseases. 2021. 29. 3. 1089-1101
Kyoko Kawahara, Tomoyuki Mukai, Masanori Iseki, Akiko Nagasu, Hajime Nagasu, Takahiko Akagi, Shoko Tsuji, Sumie Hiramatsu-Asano, Yasuyoshi Ueki, Katsuhiko Ishihara, et al. SH3BP2 Deficiency Ameliorates Murine Systemic Lupus Erythematosus. International Journal of Molecular Sciences. 2021. 22. 8. 4169-4169
Ishihara Katsuhiko, Yahagi Ayano, Iseki Masanori, Mukai Tomoyuki. マウス関節リウマチモデルgp130F759の自然免疫から獲得免疫への移行期における滑膜のシングルセルRNAシーケンシング(Single-cell RNA-sequencing of the synovium in gp130F759, a murine rheumatoid arthritis model, at the transitional phase from innate to acquired immunity). 日本免疫学会総会・学術集会記録. 2021. 50. Proceedings. 2-P
Single-cell RNA-sequencing of the synovial cells in gp130F759, a murine rheumatoid arthritis model, revealed changes in B-cell repertoire at the transitional phase from innate to acquired immunity
(The 51st Annual Meeting of the Japanese Society for Immunology 2022)
The diet-induced differences in gut microbiota determines the responder / non-responder of Daiokanzoto
(The 6th International Symposium for Japanese Kampo Medicine 2022)