Rchr
J-GLOBAL ID:201801019308153348
Update date: Jan. 31, 2024
Takumi Yamaguchi
ヤマグチ タクミ | Takumi Yamaguchi
Affiliation and department:
Homepage URL (1):
http://www.jaist.ac.jp/ms/labs/t-yamaguchi/
Research field (4):
Molecular biochemistry
, Biochemistry
, Bioorganic chemistry
, Structural/physical organic chemistry
Research keywords (5):
分子シミュレーション
, 糖鎖
, 分子認識
, NMR
, 超分子化学
Research theme for competitive and other funds (12):
- 2019 - 2021 糖鎖間相互作用のアシンメトリックな階層構造の解明と制御
- 2015 - 2019 Elucidation of the proteasome formation mechanisms through multilateral structural biology approach toward drug discovery
- 2015 - 2018 Mechanism of sugar chain elongation catalyzed by muscular dystrophy cause gene product LARGE
- 2013 - 2018 Exploration of micro-macro relationships in dynamic ordering of biomolecular systems and their underlying design principles
- 2015 - 2017 NMRデータに基づく配座空間探査による動的糖鎖コードの解読
- 2014 - 2016 Creation of functional neoglycolipid clusters for controlling stemness of neural stem cells
- 2012 - 2015 Elucidation of structural basis of glycoconjugate functions and its application for molecular design toward developing drugs targeting the carbohydrate recognition systems
- 2012 - 2015 常磁性金属修飾糖鎖を用いた過渡的相互作用の動的観察
- 2012 - 2014 Identification and structural-functional analysis of shuttle-type proteasome activator exhibiting molecular chaperone activity
- 2009 - 2011 オリゴ糖鎖ナノクラスターの精密構築と生体分子認識機構の解明
- 2009 - 2011 Elucidation of structural basis for molecular recognition and supramolecular complex formation of intracellular lectins involved in post-endoplasmic reticulum quality control
- 2005 - 2008 配位結合ナノチューブの自己組織化における精密構造制御とその機能化
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Papers (55):
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Supaphorn Seetaha, Nuntaporn Kamonsutthipaijit, Maho Yagi-Utsumi, Yanaka Seako, Takumi Yamaguchi, Supa Hannongbua, Koichi Kato, Kiattawee Choowongkomon. Biophysical Characterization of p51 and p66 Monomers of HIV-1 Reverse Transcriptase with Their Inhibitors. The protein journal. 2023
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Hiroaki Tatsuoka, Takumi Yamaguchi. NMR Analyses of CarbohydrateWater and WaterWater Interactions in Water/DMSO Mixed Solvents, Highlighting Various Hydration Behaviors of Monosaccharides Glucose, Galactose and Mannose. Bulletin of the Chemical Society of Japan. 2023. 96. 2. 168-174
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Shinnosuke Horiuchi, Takumi Yamaguchi, Jacopo Tessarolo, Hirotaka Tanaka, Eri Sakuda, Yasuhiro Arikawa, Eric Meggers, Guido H. Clever, Keisuke Umakoshi. Symmetry-breaking host-guest assembly in a hydrogen-bonded supramolecular system. Nature Communications. 2023. 14. 1
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Yoshiki Yamaguchi, Takumi Yamaguchi, Koichi Kato. Structural Analysis of Oligosaccharides and Glycoconjugates Using NMR. Advances in Neurobiology. 2023. 163-184
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Koichi Kato, Takumi Yamaguchi, Maho Yagi-Utsumi. Experimental and computational characterization of dynamic biomolecular interaction systems involving glycolipid glycans. Glycoconjugate Journal. 2022
more...
MISC (18):
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加藤晃一, 山口拓実. 糖鎖の動的構造解析. 糖鎖生物学. 2020. 109-110
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中根健汰, 鈴木達哉, 谷中冴子, 加藤晃一, 山口拓実. 動的相互作用機構解析に基づいたレクチン高親和性糖鎖の設計. 日本化学会春季年会講演予稿集(CD-ROM). 2019. 99th
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谷中冴子, 谷中冴子, 谷中冴子, 谷中冴子, 與語理那, 與語理那, 與語理那, 矢木宏和, 伊藤暁, 伊藤暁, et al. IgGのフコシル化によるFcのダイナミクスの変化がFcγ受容体との相互作用に及ぼす影響. 日本細胞生物学会大会(Web). 2019. 71st
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鈴木達哉, 鈴木達哉, 谷中冴子, 谷中冴子, 渡邉東紀男, YAN Gengwei, 佐藤匡史, 矢木宏和, 山口拓実, 加藤晃一, et al. 未結合状態の糖鎖のコンフォメーション空間の改変によるレクチン親和性の向上. 日本糖質学会年会要旨集. 2019. 38th
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山口拓実, 山口拓実, 鈴木達哉, 龍岡博亮, 谷中冴子, 矢木宏和, 佐藤匡史, 加藤晃一, 加藤晃一. 糖鎖コンフォメーション空間の改変による糖-タンパク質間相互作用の制御. ホスト-ゲスト・超分子化学シンポジウム講演要旨集. 2019. 17th
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Patents (1):
Books (6):
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分子シミュレーションによる糖鎖の3次元構造の動態予測, タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例
技術情報協会 2023 ISBN:9784861049712
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糖鎖解析技術:核磁気共鳴(NMR)法, 糖質分析
2019
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NMR characterization of the conformations, dynamics, and interactions of glycosphingolipids in NMR in Glycoscience and Glycotechnology
RSC Publishing (Cambridge) 2017
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NMR Characterization of the Dynamic Conformations of Oligosaccharides in Modern Magnetic Resonance
Springer, pp 737-754, 2018 2017
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NMR explorations of biomolecular systems with rapid conformational exchanges in Molecular Science of Fluctuations toward Biological Functions
Springer 2016
more...
Lectures and oral presentations (21):
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分子シミュレーションとクラスター分析を用いた高マンノース型糖鎖の動的立体構造解析
(第42回 日本糖質学会年会 2023)
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Description of the dynamic conformation of oligosaccharides by combining NMR spectroscopy and molecular simulation
(第60回 日本生物物理学会年会 2022)
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オリゴ糖鎖の立体構造・ダイナミクスの解析と制御
(第22回 若手NMR研究会 2022)
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Comprehensive characterization of oligosaccharide dynamical conformations by a kernel method in conjunction with graph theoretical techniques
(Pacifichem 2021 2021)
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常磁性NMR計測を活用した糖鎖の動的立体構造解析法の開発
(第38回日本糖質学会年会 2019)
more...
Education (2):
- 2003 - 2008 東京大学大学院 工学系研究科 応用化学専攻
- - 2003 The University of Tokyo The Faculty of Engineering Department of Applied Chemistry
Professional career (1):
- Ph.D from Tokyo University (2008)
Work history (2):
- 2015 - 現在 Japan Advanced Institute of Science and Technology
- 2008 - 2015 Institute for Molecular Science
Awards (4):
- 2019/08 - 日本糖質学会奨励賞
- 2014/06 - 自然科学研究機構若手研究者賞
- 2013/09 - バイオ関連化学シンポジウム講演賞
- 2013/08 - 日本糖質学会ポスター賞
Association Membership(s) (3):
THE NUCLEAR MAGNETIC RESONANCE SOCIETY OF JAPAN
, THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH
, THE CHEMICAL SOCIETY OF JAPAN
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