Nimura Keisuke

Affiliation and department：
Job title： Professor

Research field (3)： Genomics , Tumor diagnostics and therapeutics , Tumor biology

Research keywords (4)：遺伝子発現制御 , Next generation sequencing , 腫瘍治療学 , DNAバーコード

Research theme for competitive and other funds (14)：

2023 - 2026 腫瘍微小環境における多因子間相互作用ネットワーク定量的検出への挑戦
2022 - 2025 RNAスプライシング因子が誘発する転写異常による腫瘍増悪化機序の包括的理解
2021 - 2024 転写ユニティー機構を構築する多因子間相互作用の時空間的かつ定量的解明
2021 - 2024 Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions
2021 - 2024 Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions

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Papers (44)：

Airi Ishibashi, Yue Li, Yuuta Hisatomi, Noriko Ohta, Yuko Uegaki, Atsushi Tanemura, Riuko Ohashi, Koji Kitamura, Kotaro Saga, Yasuhide Yoshimura, et al. Local treatment of HVJ-E with T cell costimulatory molecule stimulation elicits systemic anti-tumor effects. Molecular therapy. Oncology. 2024. 32. 4. 200893-200893
Noriko Ohta, Takashi Matsuzaki, Masayoshi Nakai, Yasuhiko Tabata, Keisuke Nimura. Combining mRNA with PBS and calcium ions improves the efficiency of the transfection of mRNA into tumors. Molecular therapy. Nucleic acids. 2024. 35. 3. 102273-102273
Koei Shinzawa, Shinji Matsumoto, Ryota Sada, Akikazu Harada, Kaori Saitoh, Keiko Kato, Satsuki Ikeda, Akiyoshi Hirayama, Kazunori Yokoi, Atsushi Tanemura, et al. GREB1 isoform 4 is specifically transcribed by MITF and required for melanoma proliferation. Oncogene. 2023. 42. 42. 3142-3156
Wei-Ning Wang, Hanako Koguchi-Yoshioka, Keisuke Nimura, Rei Watanabe, Atsushi Tanemura, Manabu Fujimoto, Mari Wataya-Kaneda. Distinct transcriptional profiles in the different phenotypes of neurofibroma from the same neurofibromatosis 1 subject. The Journal of investigative dermatology. 2023
Satoru Hirabayashi, Yuko Tsuyuguchi, Yue Li, Noriko Ohta, Yusuke Yoshikawa, Bangzhong Lin, Megumi Fumimoto, Kazuto Nunomura, Takeyuki Suzuki, Junichi Haruta, et al. Design and synthesis of 4-acetoxypentanamide derivatives of spliceostatin A and their biological evaluation towards prostate cancer treatment. Bioorganic & medicinal chemistry letters. 2023. 129333-129333

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MISC (28)：

二村圭祐. B細胞における転写制御機構. 月刊臨床免疫・アレルギー科 (臨床免疫・アレルギー科). 2024. 81. 2. 116-121
佐々暢亜, 岸川敏博, 伊藤理恵, 佐々暢亜, 岸川敏博, 伊藤理恵, 岸川敏博, 鈴木雅美, 江口博孝, 田中秀憲, et al. HPV関連中咽頭癌におけるHPV組み込みの腫瘍内不均一性. 日本耳鼻咽喉科頭頚部外科学会会報. 2024. 127. 4
平林怜, 太田徳子, 露口結子, LI Yue, 吉川祐介, LIN Bangzhong, 文元めぐみ, 春田純一, 佐古真, 村井健一, et al. Design and Synthesis of Spliceostatin A Derivatives: Structure-Activity-Relationship Study related to Enone moiety of Spliceostatin A. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
波多野浩士, 岡利樹, 二村圭祐, 石津谷祐, 奥田洋平, 植村俊彦, 山道岳, 冨山栄輔, 山本致之, 加藤大悟, et al. Systematic mapping of radiosensitivity and gene interactions identifies a novel therapeutic target in prostate cancer. 日本泌尿器科学会総会(Web). 2023. 110th
二村圭祐. The mechanisms of tumor progression caused by RNA splicing factor-induced aberrant transcription. 日本癌学会学術総会抄録集(Web). 2023. 82nd

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Education (4)：

2003 - 2007 Osaka University Graduate School of Medicine
2001 - 2003 Nara Institute of Science and Technology
1997 - 2001 Nagoya University School of Science Department of Biological Science
1994 - 1997 三重県立四日市高等学校・国際科学コース

Professional career (1)：

博士(医学) (大阪大学)

Work history (6)：

2023/04 - 現在 Gunma University Division of Gene Therapy Science, Gunma University Initiative for Advanced Research
2014/07 - 2024/06 大阪大学大学院医学系研究科遺伝子治療学准教授
2014/10 - 2015/12 National Institutes of Health NIAMS (Dr. Rafael Casellas研究室) Visiting fellow
2010/04 - 2014/06 大阪大学大学院医学系研究科遺伝子治療学助教
2008/04 - 2010/03 大阪大学大学院医学系研究科遺伝子治療学特任研究員

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Awards (2)：

2023/11 - 群馬大学ディスティングイッシュトヤングリサーチャー
2013 - 大阪大学総長奨励賞

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