Research keywords (3):
ハプロタイプフェージング
, ダウン症
, トリソミックレスキュー
Research theme for competitive and other funds (5):
2021 - 2025 Establishing the type I CRISPR platform for extra chromosome elimination through epigenetic modulation
2020 - 2023 エクソソームを利用した後天的トリソミックレスキュー法の構築
2018 - 2020 Search for micronucleus migration trigger proteins and their application to acquired trisomic rescue
2016 - 2019 Proof of concept study of a novel excess chromosome elimination therapy to ameliorate and prevent trisomy 21 associated complications
2016 - 2018 Trisomic rescue induction by allele-specific chromosome breakage using genome editing technique
Papers (9):
Sachiko Wakita, Mari Hara, Yasuji Kitabatake, Keiji Kawatani, Hiroki Kurahashi, Ryotaro Hashizume. Experimental method for haplotype phasing across the entire length of chromosome 21 in trisomy 21 cells using a chromosome elimination technique. Journal of human genetics. 2022. 67. 10. 565-572
Takehisa Kawata, Nobuo Nagano, Masaki Obi, Sonoe Miyata, Chika Koyama, Nami Kobayashi, Sachiko Wakita, Michihito Wada. Cinacalcet suppresses calcification of the aorta and heart in uremic rats. Kidney international. 2008. 74. 10. 1270-7
Nobuo Nagano, Sonoe Miyata, Megumi Abe, Sachiko Wakita, Nami Kobayashi, Michihito Wada. Sevelamer hydrochloride reverses parathyroid gland enlargement via regression of cell hypertrophy but not apoptosis in rats with chronic renal insufficiency. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006. 21. 3. 634-43
Phasing on the entire length of chromosome by chromosome elimination using genome
(the 63rd annual Meeting of the Japan society of human Genetics 2018)
Haplotype phasing of trisomy 21 by chromosome elimination
(The 25th Annual Meeting of the Japanese Society for Gene Diagnosis and Therapy 2018)