Rchr
J-GLOBAL ID：201801019371273809   Update date: Sep. 15, 2024

Onishi Nobuyuki

オオニシ ノブユキ | Onishi Nobuyuki
Affiliation and department：
Showa University Dept. of Clin. Diag Oncol., Clin. Res. Inst. for Clin. Pharmacol. and Ther.

About Showa University Dept. of Clin. Diag Oncol., Clin. Res. Inst. for Clin. Pharmacol. and Ther.


Other affiliations (1)：
  • Keio University  School of Medicine Department of Plastic and Reconstructive Surgery 
Research field  (3)： Molecular biology ,  Laboratory animal science ,  Tumor biology
Research theme for competitive and other funds  (5)：
  • 2019 - 2022 Development of easy-to-use genome editing protein synthesis system and one-step genetically modified animal production method
  • 2016 - 2019 Development of novel mouse brain tumor model using in vivo electroporation and piggyBac system
  • 2013 - 2015 Development of recurrence mouse brain tumor model using inducible iCSCs and identification of target molecules in recurrence tumor
  • 2010 - 2011 Establishment of human induced cancer stem cells(iCSCs) and malignant brain tumor models derived from neural stem cells
  • 2005 - 2007 DNA損傷応答におけるWip1による細胞周期チェックポイントの解除機構
Papers (42)：
  • Hiroshi Onji, Sota Tate, Tomohisa Sakaue, Kohei Fujiwara, Shiho Nakano, Miho Kawaida, Nobuyuki Onishi, Takashi Matsumoto, Wataru Yamagami, Takashi Sugiyama, et al. Schlafen 11 further sensitizes BRCA-deficient cells to PARP inhibitors through single-strand DNA gap accumulation behind replication forks. Oncogene. 2024
  • Tsubasa Goshima, Katsuaki Ieguchi, Nobuyuki Onishi, Takashi Shimizu, Daisuke Takayanagi, Makoto Watanabe, Yuki Fujimoto, Ryotaro Ohkuma, Risako Suzuki, Toshiaki Tsurui, et al. Non-classical Monocytes Enhance the Efficacy of Immune Checkpoint Inhibitors on Colon Cancer in a Syngeneic Mouse Model. Anticancer research. 2024. 44. 1. 23-29
  • Fujii Takashi, Nakano Yoshiko, Hagita Daichi, Onishi Nobuyuki, Endo Arumu, Nakagawa Masaya, Yoshiura Toru, Otsuka Yohei, Takeuchi Satoru, Suzuki Mario, et al. KLC1-ROS1 Fusion Exerts Oncogenic Properties of Glioma Cells via Specific Activation of JAK-STAT Pathway. Cancers. 2023. 16. 1
  • Ryotaro Ohkuma, Sakiko Miura, Satoshi Muto, Yoshitaka Toyomasu, Yuki Fujimoto, Katsuaki Ieguchi, Nobuyuki Onishi, Takashi Shimizu, Makoto Watanabe, Daisuke Takayanagi, et al. Novel quantitative immunohistochemical analysis for evaluating PD-L1 expression with phosphor-integrated dots for predicting the efficacy of patients with cancer treated with immune checkpoint inhibitors. Frontiers in immunology. 2023. 18. 14. 1260492-1260492
  • Ryotaro Ohkuma, Yuki Fujimoto, Katsuaki Ieguchi, Nobuyuki Onishi, Makoto Watanabe, Daisuke Takayanagi, Tsubasa Goshima, Atsushi Horiike, Kazuyuki Hamada, Hirotsugu Ariizumi, Yuya Hirasawa, Tomoyuki Ishiguro, Risako Suzuki, Nana Iriguchi, Toshiaki Tsurui, Yosuke Sasaki, Mayumi Homma, Toshiko Yamochi, Kiyoshi Yoshimura, Mayumi Tsuji, Yuji Kiuchi, Shinichi Kobayashi, Takuya Tsunoda, Satoshi Wada. Monocyte subsets associated with the efficacy of anti-PD-1 antibody monotherapy. Oncol Lett. 2023. 26. 3. 381-381
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MISC (42)：
  • 家口 勝昭, 大西 伸幸, 大熊 遼太朗, 角田 卓也, 和田 聡. EphA2/ephrin-A1シグナル伝達を介したPD-L1の発現調節機構(Expression of PD-L1 is regulated by the EphA2/ephrin-A1 signaling pathway). 日本癌学会総会記事. 2023. 82回. 1829-1829
  • 五嶋 翼, 家口 勝昭, 大西 伸幸, 高柳 大輔, 渡邊 真, 大熊 遼太朗, 鈴木 理沙子, 入口 菜々, 石黒 智之, 平澤 優弥, et al. 免疫チェックポイント阻害薬の効果予測バイオマーカーの探索及びICI併用療法の検討. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 115-115
  • 家口 勝昭, 大西 伸幸, 渡邊 真, 五嶋 翼, 鈴木 梨沙子, 大熊 遼太朗, 辻 まゆみ, 木内 祐二, 角田 卓也, 小林 真一, et al. 転移前微小環境形成における骨髄由来免疫抑制細胞と交感神経の連関機能. 日本がん免疫学会総会プログラム・抄録集. 2023. 27回. 135-135
  • 五嶋 翼, 大熊 遼太朗, 家口 勝昭, 大西 伸幸, 堀池 篤, 辻 まゆみ, 木内 祐二, 内田 直樹, 小林 真一, 藤代 準, et al. 免疫チェックポイント阻害薬の効果予測バイオマーカーの探索. 日本臨床薬理学会学術総会抄録集. 2022. 43回. 1-4
  • 和田 聡, 大熊 遼太郎, 鈴木 梨沙子, 家口 勝昭, 大西 伸幸, 渡邊 真, 吉村 清, 内田 直樹, 辻 まゆみ, 木内 祐二, et al. がん免疫療法におけるバイオマーカーの探索. 日本臨床薬理学会学術総会抄録集. 2022. 43回. 1-5
ｍore...
Education (2)：
  • 2002 - 2008 Kobe University
  • 1998 - 2002 Kindai University Faculty of Science and Engineering
Professional career (1)：
  • 博士(医学) (神戸大学)
Work history (9)：
  • 2022/10 - 現在 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
  • 2022/05 - 現在 Showa University Dept. of Clin. Diag Oncol., Clin. Res. Inst. for Clin. Pharmacol. and Ther.
  • 2022/05 - 2022/09 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
  • 2022/04 - 2022/04 Keio University School of Medicine Department of Plastic and Reconstructive Surgery
  • 2017/04 - 2022/03 株式会社 島津製作所 基盤技術研究所 嘱託研究員
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