Hajime Mizuno

ミズノハジメ | Hajime Mizuno

Affiliation and department：
Job title： Professor

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (2)：質量分析 , 分析化学

Research theme for competitive and other funds (10)：

2022 - 2025 Development of sensitive intracellular molecular analytical method by single-cell organelle injection and derivatization
2022 - 2025 Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
2019 - 2022 Development of mitochondrial mass spectrometry in live single-cell.
2016 - 2019 Subcellular molecular localization analysis by in situ derivatization
2012 - 2016 Development of low polar molecules-targetted Live single-cell MS by piezo-oscillated nano-CI.

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Papers (69)：

Yuko Terada, Takumi Hisada, Masaya Fujitani, Ryoka Nakayama, Serina Fukui, Kei Kanie, Ryuji Kato, Takashi Shigeta, Eiji Sugiyama, Hajime Mizuno, et al. (S)-2,5-dioxopyrrolidin-1-yl-1-(4,6-dimethoxy-1,3,5-triazin-2-yl)pyrrolidine-2-carboxylate derivatization combined with UPLC/ESI-MS/MS as a powerful method for dipeptide determination in foods: an application example in fermented cocoa beans. Journal of Food Composition and Analysis. 2024. 106759-106759
Tomohiro Yamada, Kaori Tsukakoshi, Aogu Furusho, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Takeshi Yamano, Hideki Kumobayashi, Takashi Hasebe, Kazunori Ikebukuro, et al. Simple and fast one-step FRET assay of therapeutic mAb bevacizumab using anti-idiotype DNA aptamer for process analytical technology. Talanta. 2024. 277. 126349-126349
Jo Sakata, Aogu Furusho, Eiji Sugiyama, Iwao Sakane, Kenichiro Todoroki, Hajime Mizuno. Development of a highly efficient solubilization method for mass spectrometric analysis of phospholipids in living single cells. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2024
Kenichiro Todoroki, Nan Fukudo, Yuto Kudoh, Hajime Mizuno, Jun Zhe Min, Shimako Tanaka, Shinya Uchida, Noriyuki Namiki, Toshimasa Toyo'oka. Development of an on-site therapeutic drug monitoring method using a portable spectrometer. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2024
Kenichiro Todoroki, Daichi Hamada, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kaori Tsukakoshi, Kazunori Ikebukuro. Development of a liquid chromatography-based versatile bioanalysis for bevacizumab based on pretreatment combining aptamer affinity purification and centrifugal ultrafiltration concentration. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023

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MISC (50)：

濱田大地, 齋藤太郎, 清水裕, 杉山栄二, 塚越かおり, 水野初, 豊岡利正, 池袋一典, 轟木堅一郎. 抗イディオタイプDNAアプタマー固定化セファロースを用いる抗体医薬のアフィニティー精製-LC分析法の開発. 分析化学討論会講演要旨集(Web). 2023. 83rd
杉山栄二, 水野初, 轟木堅一郎. 医化学研究における質量分析の応用~イメージングから血液マーカー開発まで~ ジアステレオマー誘導体化によるキラル分子のエナンチオ選択的イメージング. JSBMS Letters. 2022. 47. Suppl. 48-48
阪田晟, 水野初, 古庄仰, 杉山栄二, 轟木堅一郎. 1細胞質量分析によるがん特異的代謝物の探索. JSBMS Letters. 2022. 47. Suppl. 91-91
小林直央, 北條泰成, 後藤厚子, 杉山栄二, 水野初, 驫木堅一郎. 3種抗体医薬に対する高親和性DNAアプタマーの効率的な探索とその評価. 日本薬学会年会要旨集. 2022. 142年会. 26H-pm17S
竹内大揮, 阪田晟, 加藤良浩, 水野初, 工藤忍, 坂根巌, 杉山栄二, 轟木堅一朗. 1細胞質量分析による細胞内リン脂質分析法の開発. 日本薬学会年会要旨集. 2022. 142年会. 27PO3-11S

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Education (2)：

- 2007 Hiroshima University Graduate School of Science Department of Mathematical and Life Sciences
- 2003 Hiroshima University Faculty of Science Department of Chemistry

Professional career (1)：

博士(理学) (広島大学)

Work history (6)：

2022/04 - 現在 Meijo University Faculty of Pharmacy Professor
2020/04 - 2022/03 University of Shizuoka School of Pharmaceutical Sciences
2017/09 - 2020/03 University of Shizuoka School of Pharmaceutical Sciences
2015/04 - 2017/08 University of Shizuoka School of Pharmaceutical Sciences
2013/04 - 2015/03 理化学研究所生命システム研究センター研究員

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Awards (1)：

2013/09 - 日本分析化学会奨励賞

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