Shirakawa Ryutaro

シラカワリュウタロウ | Shirakawa Ryutaro

Affiliation and department：

Research field (2)： Medical biochemistry , Molecular biology

Research theme for competitive and other funds (12)：

2024 - 2027 Development of a platform for evaluating the environmental response to von Willebrand factor during circulatory assist
2023 - 2027 Research of high-shear stress-induced hemostatic disorder
2021 - 2025 リソソーム維持機構の理解に基づく神経変性疾患の革新的治療法開発
2019 - 2022 Molecular Mechanism of Tumor Supression by RalGAP and Biguanides
2016 - 2019 Molecular Mechanisms of Tumorigenesis, Invasion, and Metastasis by the Small GTPase Ral

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Papers (58)：

Noriyuki Okubo, Shingo Sugawara, Tohru Fujiwara, Ko Sakatsume, Tsuyoshi Doman, Mihoko Yamashita, Kota Goto, Masaki Tateishi, Misako Suzuki, Ryutaro Shirakawa, et al. von Willebrand factor Ristocetin co-factor activity to von Willebrand factor antigen level ratio for diagnosis of acquired von Willebrand syndrome caused by aortic stenosis. Research and Practice in Thrombosis and Haemostasis. 2023. 102284-102284
Atsushi Kubo, Keisuke Hitachi, Ryutaro Shirakawa, Toshihiko Ogura. Protective effects of Mkl1/2 against lipodystrophy and muscle atrophy via PI3K/AKT-independent FoxO repression. bioRxiv. 2023
Koyu Ito, Kota Goto, Ryutaro Shirakawa, Hisanori Horiuchi, Kouetsu Ogasawara. Platelet αIIbβ3 integrin binds to SARS-CoV-2 spike protein of alpha strain but not wild type and omicron strains. Biochemical and Biophysical Research Communications. 2023. 657. 80-85
Mingxin Cao, Xinming Li, Duc-Anh Trinh, Shingo Yoshimachi, Kota Goto, Natsumi Sakata, Masaharu Ishida, Hideo Ohtsuka, Michiaki Unno, Yuxia Wang, et al. Ral GTPase promotes metastasis of pancreatic ductal adenocarcinoma via elevation of TGF-β1 production. The Journal of Biological Chemistry. 2023. 104754-104754
Shingo Yoshimachi, Ryutaro Shirakawa, Mingxin Cao, Duc Anh Trinh, Pan Gao, Natsumi Sakata, Kento Miyazaki, Kota Goto, Takayuki Miura, Kyohei Ariake, et al. Ral GTPase-activating protein regulates the malignancy of pancreatic ductal adenocarcinoma. Cancer Science. 2021

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MISC (24)：

K. Saito, K. Sakatsume, R. Shirakawa, T. Kimura, M. Akiyama, Y. Saiki, H. Horiuchi. Accuired von Willebrand syndrome in patients treated with left ventricular assist devices. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015. 13. 744-744
H. Horiuchi, N. Yaoita, R. Shirakawa. Evaluation of activation states of small GTPases in patient platelets. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013. 11. 1139-1140
白川龍太郎, 堀内久徳. 血小板系血小板顆粒放出異常症と遺伝子異常. Annual Review血液. 2013. 2013. 182-189
R. Saito, T. Kobayashi, M. Nakashima, Y. Matsui, N. Shibasaki, T. Inoue, H. Nishiyama, R. Shirakawa, H. Horiuchi, O. Ogawa. RalGAP, the Inactivator of Ral Small GTPase, Suppresses the Invasion and Metastasis of Prostate Cancer. UROLOGY. 2012. 80. 3. S278-S278
R. Saito, T. Kobayashi, M. Nakashima, Y. Matsui, N. Shibasaki, T. Kanno, T. Inoue, H. Nishiyama, R. Shirakawa, H. Horiuchi, et al. RalGAP, the inactivator of Ral small GTPase, suppresses the progression of prostate cancer. EUROPEAN UROLOGY SUPPLEMENTS. 2012. 11. 1. E839-U771

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Education (3)：

Professional career (1)：

Work history (4)：

2022/09 - 現在 Institute of Development, Aging and Cancer, Tohoku University Department of Molecular and Cellular Biology Lecturer
2021/07 - 現在東北大学プロミネントリサーチフェロー
2010/04 - 2022/08 Tohoku University Institute of Development, Aging and Cancer
2007/04 - 2010/03 京都大学大学院医学研究科学術振興会特別研究員PD

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