Akiyama Yoshimitsu

アキヤマヨシミツ | Akiyama Yoshimitsu

Research field (1)： Tumor biology

Research keywords (4)： Hereditary cancer , DNA mismatch repair , Epigenetics , Gastrointestinal cancer

Research theme for competitive and other funds (21)：

2020 - 2023 Envolvement of abnormal of SETDB-related histone modification enzyme and tumor immune environment in gastrointestinal cancer
2020 - 2022 Application of multiplex genome editing technology to the development of CAR-T therapy for refractory cancer subtypes
2019 - 2022 Clarification of diversity mechanisms for innovation of refractory cancer treatment
2018 - 2020 Innovation of genome editing technology as the basis to develop molecular subtype panels of intractable cancer
2016 - 2020 Molecular pathology of SET-related histone methyltransferase in refractory cancer

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Papers (112)：

梅村謙太郎, 秋山好光, 島田周, 羽多野恵, 安川紘矢, 蒲池厚志, 田邉稔, 田中真二. 膵癌の新規エピゲノム異常の解明と標的治療の開発. 日本消化器外科学会雑誌. 2023. 56. Suppl.2. 545-545
Megumi Hatano, Yoshimitsu Akiyama, Shu Shimada, Kohei Yagi, Keiichi Akahoshi, Michiko Itoh, Minoru Tanabe, Yoshihiro Ogawa, Shinji Tanaka. Loss of KDM6B epigenetically confers resistance to lipotoxicity in nonalcoholic fatty liver disease-related HCC. Hepatology communications. 2023. 7. 10
安川紘矢, 島田周, 秋山好光, 田中真二. 肝癌における免疫治療抵抗性の解明乳酸代謝からみた新規治療法への展開(Elucidation of immunotherapy resistance in hepatocellular carcinoma: Novel treatment based on lactate metabolism). 日本癌学会総会記事. 2023. 82回. 1147-1147
Ayano Kabashima, Yuki Matsuo, Saki Ito, Yoshimitsu Akiyama, Takeshi Ishii, Shu Shimada, Atsushi Masamune, Minoru Tanabe, Shinji Tanaka. cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer. Scientific reports. 2022. 12. 1. 10466-10466
Hiroaki Ono, Tomotaka Kato, Yoshiki Murase, Yutaro Nakamura, Yoshiya Ishikawa, Shuichi Watanabe, Keiichi Akahoshi, Toshiro Ogura, Kosuke Ogawa, Daisuke Ban, et al. C646 inhibits G2/M cell cycle-related proteins and potentiates anti-tumor effects in pancreatic cancer. Scientific Reports. 2021. 11. 1

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MISC (9)：

梅村謙太郎, 梅村謙太郎, 秋山好光, 島田周, 羽多野恵, 安川紘矢, 安川紘矢, 蒲池厚志, 蒲池厚志, 田邉稔, et al. 膵癌の新規エピゲノム異常の解明と標的治療の開発. 日本消化器外科学会雑誌(Web). 2023. 56. Supplement2
安川紘矢, 安川紘矢, 島田周, 秋山好光, 田中真二. Elucidation of immunotherapy resistance in hepatocellular carcinoma: Novel treatment based on lactate metabolism. 日本癌学会学術総会抄録集(Web). 2023. 82nd
安川紘矢, 秋山好光, 島田周, 田中真二. 【胆道疾患研究最前線】胆道癌の分子生物学的サブタイプと治療戦略. 消化器・肝臓内科. 2022. 11. 1. 33-42
田中真二, 島田周, 秋山好光, 大庭篤志, 渡辺秀一, 奥野圭祐, 水野裕貴, 上田浩樹, 吉野潤, 菅原了子, et al. ゲノム医療・ゲノム編集時代におけるプレシジョン免疫複合療法. 日本外科学会定期学術集会(Web). 2019. 119th
Eriko Katsuta, Shinji Tanaka, Kaoru Mogushi, Shu Shimada, Yoshimitsu Akiyama, Arihiro Aihara, Satoshi Matsumura, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, et al. CD73: A therapeutic target for pancreatic neuroendocrine tumor stem cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2016. 38. S5-S5

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Awards (2)：

2005/09 - The Japanese Cancer Association The Young Investigator Awards of the Japanese Cancer Association
2000/04 - American Association for Cancer Research-ITO-EN Young Investigator Award APC and β-catenin gene mutations in colorectal adenomas from HNPCC patients.

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