Sotogaku Naoki

ソトガクナオキ | Sotogaku Naoki

Affiliation and department：

Research field (1)： Other

Research theme for competitive and other funds (24)：

2020 - 2023 敗血症関連脳症におけるメラトニンとテトラヒドロビオプテリンのクロストーク解析
2019 - 2022 Pharmacological treatment of depression: development of novel therapeutics targeting the dopamine neuronal system
2018 - 2021 Investigation of the interaction between dopamine and noradrenaline signaling in the hippocampus to develop novel treatment of depression
2017 - 2020 Melatonin signaling pathway as a novel target for the treatment for sepsis-associated encephalopathy
2018 - 2020 再生医療を指向したヒトiPS細胞からドパミン作動性細胞への効率的分化誘導と細胞機能解析

2016 - 2019 Investigation of dopamine neurocircuits to identify novel therapeutic targets in psychiatric disorders

2014 - 2017 細胞外マトリックス糖鎖分子による神経細胞の形態形成制御機構

2016 - 治療抵抗性うつ病の病態解明と治療法開発

2014 - 細胞外マトリックス糖鎖分子による神経細胞の形態形成制御機構

2010 - 2013 神経再生を制御するコンドロイチン硫酸の糖鎖構造と作用分子機構

2013 - 細胞外マトリックス糖鎖分子による大脳皮質形成の制御機構

2011 - ニューロンへの分化を促進する細胞外マトリックス糖鎖分子

2008 - 2010 コンドロイチン硫酸による神経損傷再生の制御機構

2010 - 神経再生を制御するコンドロイチン硫酸の糖鎖構造と作用分子機構

2006 - 2008 ドーパミン神経保護作用を示すプロテオグリカンの構造とその作用分子機構

2008 - コンドロイチン硫酸による神経損傷再生の制御機構

2006 - 2007 Map of dopamine signaling in the neostriatum under normal and pathophysiological conditions

2004 - 2006 ドーパミン神経の分化・発達・再生を調節する糖鎖の構造と細胞内シグナル伝達機構

2006 - ドーパミン神経保護作用を示すプロテオグリカンの構造とその作用分子機構

2006 - Synthetic chondroitin sulfate E tetrasaccharide promotes neurite outgrowth of dopaminergic neurons.

2004 - 2005 Effects of proteoglycans on the membrane dysfunction produced by in vitro ischemia in the rat hippocampal CA1 neurons.

2004 - 2005 Map of dopamine signaling in the neostriatum

2005 - ドーパミン神経の機能制御におけるコンドロイチン硫酸プロテオグリカンの役割

2003 - 2004 Role of GABA_B receptors in dopamine/DARPP-32 signaling

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Papers (27)：

Ryusuke Sin, Naoki Sotogaku, Yoshinori N. Ohnishi, Takahide Shuto, Mahomi Kuroiwa, Yukie Kawahara, Keita Sugiyama, Yuki Murakami, Masaaki Kanai, Hiroshi Funakoshi, et al. Inhibition of STAT-mediated cytokine responses to chemically-induced colitis prevents inflammation-associated neurobehavioral impairments. Brain, Behavior, and Immunity. 2023
Yuki Kishikawa, Yukie Kawahara, Yoshinori N. Ohnishi, Naoki Sotogaku, Tomoko Koeda, Hiroshi Kawahara, Akinori Nishi. Dysregulation of dopamine neurotransmission in the nucleus accumbens in immobilization-induced hypersensitivity. Frontiers in Pharmacology. 2022. 13
Hashizume N, Shin R, Akiba J, Sotogaku N, Asagiri K, Hikida S, Fukahori S, Ishii S, Saikusa N, Koga Y, et al. The herbal medicines Inchinkoto and Saireito improved hepatic fibrosis via aquaporin 9 in the liver of a rat bile duct ligation model. Pediatr Surg Int. 2021
沈龍佑, 外角直樹, 河原幸江, 西昭徳. 炎症性腸疾患に合併するうつ病・不安障害の病態解明とトリプトファン代謝酵素阻害薬680C91の治療効果の解析. 臨床薬理. 2020. 51. Suppl. S267-S267
Takatoshi Hikida, Makiko Morita, Mahomi Kuroiwa, Tom Macpherson, Takahide Shuto, Naoki Sotogaku, Minae Niwa, Akira Sawa, Akinori Nishi. Adolescent psychosocial stress enhances sensitization to cocaine exposure in genetically vulnerable mice. Neuroscience research. 2020. 151. 38-45

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Patents (1)：

Books (3)：

Education (3)：

1998 - 2001 University of Shizuoka Graduate School of Pharmaceutical Sciences
1996 - 1998 Showa Pharmaceutical University Graduate School Research Division in Pharmaceutical Sciences
1992 - 1996 Showa Pharmaceutical University Faculty of Pharmaceutical Sciences

Work history (5)：

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