Tomiyasu Hirotaka

トミヤスヒロタカ | Tomiyasu Hirotaka

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://park.itc.u-tokyo.ac.jp/naika/index.html

Research field (1)： Veterinary medicine

Research keywords (5)： Next generation sequencing , exosome , Cancer immunology , Tumor microenvironment , Chemotherapy resistance

Research theme for competitive and other funds (11)：

2023 - 2028 Establishment of novel chemotherapy for canine tumors by drug repositioning
2023 - 2026 生殖細胞系列のCHEK2遺伝子欠損に起因するイヌの腫瘍の病態及び分子生物学的解析
2022 - 2026 Investigations of the relationship between antitumor immunity and chemotherapy resistance focusing on heterogeneity in tumor tissues
2020 - 2024 犬固形腫瘍に対する低コストかつレディメイドで適応可能なCAR-T細胞製剤の開発
2020 - 2023 Elucidation of molecular mechanisms of chemotherapy resistance based on interactions between tumor cells and immune cells

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Papers (71)：

Yong Bin Teoh, Teita Ishizaki, Yumiko Kagawa, Shoko Yokoyama, Jaroslav Jelinek, Yuki Matsumoto, Hirotaka Tomiyasu, Hajime Tsujimoto, Mitsuyoshi Takiguchi, Jumpei Yamazaki. Use of genome-wide DNA methylation analysis to identify prognostic CpG site markers associated with longer survival time in dogs with multicentric high-grade B-cell lymphoma. Journal of veterinary internal medicine. 2024. 38. 1. 316-325
Taiga Yamada, Marika Ishimaru, Takuma Shoji, Hirotaka Tomiyasu, Ryota Tochinai, Kazuaki Taguchi, Teruyuki Komatsu. Polyoxazoline-Conjugated l-Asparaginase: An Antibody-Production-Free Therapeutic Agent for Acute Lymphoblastic Leukemia. ACS Applied Bio Materials. 2023
Hiroto Toyoda, Akiyoshi Tani, Yuko Goto-Koshino, Tomoki Motegi, Mika Sakamoto, Takako Mochizuki, Kei Harada, Tetsuya Kobayashi, Asuka Setoguchi, Yohei Shizuta, et al. Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma. The Journal of veterinary medical science. 2023
Itsuma Nagao, Kanako Tsuji, Yuko Goto-Koshino, Masaya Tsuboi, James K Chambers, Kazuyuki Uchida, Satoshi Kambayashi, Hirotaka Tomiyasu, Kenji Baba, Masaru Okuda. MUC5AC and MUC5B expression in canine gallbladder mucocele epithelial cells. The Journal of veterinary medical science. 2023
Hsin-Pei Weng, Chiao-Hsu Ke, Chun-Wei Tung, Akiyoshi Tani, Chia-Chi Wang, Wen-Yuan Yang, Yu-Shan Wang, Winston Han, Chi-Hsun Liao, Hirotaka Tomiyasu, et al. Canine diffuse large b-cell lymphoma downregulates the activity of CD8 + T-cells through tumor-derived extracellular vesicles. Cancer cell international. 2023. 23. 1. 252-252

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MISC (41)：

阪本恵美, 富安博隆. 猫の腫瘍別プロトコル解説集抗がん薬の組み合わせを理解する!リンパ腫(レスキュー療法). Veterinary Oncology. 2023. 10. 1
富安博隆. 見落としてはいけない!猫のリンパ腫総論:猫に発生する代表的なリンパ腫に関するアップデート. Veterinary Board. 2023. 5. 9
佐久間大樹, 富安博隆, 富安博隆. 見落としてはいけない!猫のリンパ腫症例報告〈1〉:眼窩を原発としたリンパ腫と診断し長期寛解を得た猫の一例. Veterinary Board. 2023. 5. 9
富安博隆. Necessity and Prospects of Artificial Blood Products in Veterinary Medicine. 人工血液. 2023. 31. 1
赤熊帆波, 富安博隆. 見落としてはいけない!犬のリンパ腫症例報告〈3〉:卵巣原発を疑うリンパ腫を発症した犬の一例. Veterinary Board. 2023. 5. 10

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Lectures and oral presentations (28)：

非再生性免疫介在性貧血の現状
(第20回日本獣医内科学アカデミー学術大会 2024)
フローサイトメトリー解析のすゝめ〜血液腫瘍における有用性〜
(第20回日本獣医内科学アカデミー学術大会 2024)
犬の血液腫瘍における臨床的挙動と関連するゲノム配列/遺伝子発現の経時的解析
(第4回コンパニオンアニマルのゲノム医療研究会 2024)
Comparative Oncology ~Clinical and molecular pathology of canine and human histiocytic sarcoma~
(One Health Seminar and International Course 2024)
犬のリンパ腫細胞由来エクソソームを介した腫瘍細胞と免疫細胞の相互作用の解析
(第166回日本獣医学会学術集会 2023)

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Education (3)：

2010 - 2014 the University of Tokyo Graduate School of Agricultural and Life Sciences
2006 - 2010 the University of Tokyo Faculty of Agriculture
2004 - 2006 the University of Tokyo

Professional career (1)：

博士(獣医学) (東京大学)

Work history (5)：

2021/11 - 現在 The University of Tokyo Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences Associate Professor
2018/02 - 2021/10 the University of Tokyo Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences Assistant Professor
2016/04 - 2018/01 the University of Tokyo Veterinary Medical Center, Graduate School of Agricultural and Life Sciences Project Assistant Professor
2015/11 - 2016/03 the University of Tokyo Veterinary Medical Center, Graduate School of Agricultural and Life Sciences Project Researcher
2014/04 - 2015/10 University of Minnesota Veterinary Clinical Sciences, College of Veterinary Medicine Postdoctoral Associate

Awards (1)：

2014/03 - the University of Tokyo Dean's Award

Association Membership(s) (6)：

American Association for Cancer Research , Veterinary Cancer Society , THE JAPANESE SOCIETY OF HEMATOLOGY , THE JAPANESE SOCIETY OF VETERINARY SCIENCE , Japanese College of Veterinary Internal Medicine , Japanese Cancer Association

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