Katsuumi Goro

カツウミゴロウ | Katsuumi Goro

Affiliation and department：
Job title： Project Assisant Professor

Research field (1)： Cardiology

Research keywords (4)： senolysis , cellular senescence , Heart , Cardiology

Research theme for competitive and other funds (2)：

2022 - 2025 Mechanism about evasion of senescent cell from removal by immunity during aging and cardiometabolic stress
2019 - 2022 Identification of novel senolytic drugs to treat age-related diseases

Papers (61)：

Goro Katsuumi, Ippei Shimizu, Masayoshi Suda, Yohko Yoshida, Takaaki Furihata, Yusuke Joki, Chieh-Lun Hsiao, Liang Jiaqi, Shinya Fujiki, Manabu Abe, et al. SGLT2 inhibition eliminates senescent cells and alleviates pathological aging. Nature aging. 2024
Masayoshi Suda, Goro Katsuumi, Tamar Tchkonia, James L Kirkland, Tohru Minamino. Potential Clinical Implications of Senotherapies for Cardiovascular Disease. Circulation journal : official journal of the Japanese Circulation Society. 2023
Ryo Furuuchi, Ippei Shimizu, Yohko Yoshida, Goro Katsuumi, Masayoshi Suda, Yoshiaki Kubota, Kenneth Walsh, Tohru Minamino. Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue. iScience. 2022. 25. 11. 105424-105424
Yohko Yoshida, Ippei Shimizu, Atsuhiro Shimada, Keita Nakahara, Sachiko Yanagisawa, Minoru Kubo, Shinji Fukuda, Chiharu Ishii, Hiromitsu Yamamoto, Takamasa Ishikawa, et al. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Scientific reports. 2022. 12. 1. 14883-14883
Yuka Hayashi, Ippei Shimizu, Yohko Yoshida, Ryutaro Ikegami, Masayoshi Suda, Goro Katsuumi, Shinya Fujiki, Kazuyuki Ozaki, Manabu Abe, Kenji Sakimura, et al. Coagulation factors promote brown adipose tissue dysfunction and abnormal systemic metabolism in obesity. iScience. 2022. 25. 7. 104547-104547

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MISC (36)：

蕭捷倫, 勝海悟郎, 須田将吉, 清水逸平, 吉田陽子, 降旗高明, 上木裕介, 古内亮, 蕭詠てい, 唐敬遠, et al. Vaccination for senescence-associated glycoprotein ameliorates Alzheimer’s pathology and cognitive behavior in mice. 日本抗加齢医学会総会プログラム・抄録集. 2023. 23rd
仲尾政晃, 清水逸平, 吉田陽子, 勝海悟郎, 林由香, 須田将吉, 南野徹. Increased Metabolites Do not Mediate Cardioprotective Effects of Empagliflozin in a Murine Left Ventricular Pressure Overload Model. 日本循環器学会学術集会(Web). 2021. 85th
須田将吉, 清水逸平, 吉田陽子, 勝海悟郎, 林由香, 池上龍太郎, 南野徹. 新規老化関連分子SAGPを標的とした抗老化治療. 日本臨床分子医学会学術総会プログラム・抄録集. 2019. 56回. 50-50
勝海悟郎, 清水逸平, 吉田陽子, 林由香, 池上龍太郎, 須田将吉, 若杉嵩幸, 仲尾政晃, 長澤綾子, 南野徹. A Novel Senolytic Drug for Aging and Age-related Cardiometabolic Disorders(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. PJ126-4
Suda Masayoshi, Shimizu Ippei, Yoshida Yohko, Hayashi Yuka, Ikegami Ryutaro, Katsuumi Goro, Wakasugi Takayuki, Nagasawa Ayako, Nakao Masaaki, Ozawa Takuya, et al. Senescence-associated Glycoprotein(SAGP) Inhibits Age-related Endothelial Dysfunction by the Regulating Mitophagy in Vascular Diseases(和訳中). 日本循環器学会学術集会抄録集. 2019. 83回. FRS09-3

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Lectures and oral presentations (24)：

Senolysis through immunomodulation against pathologies of cardio-metabolic diseases
(2024)
一細胞解析に基づく老化細胞の多様性の理解と治療開発
(第97回日本薬理学会年会 2023)
Sodium Glucose Co-Transporter 2 Inhibition Eliminates Senescent Cells Through Downregulation of PD-L1 and Improves Pathological Aging.
(AHA scientific sessions 2023 2023)
Seno-antigen and senolytic therapy with utilization of immune function.
(2023)
Canagliflozin eliminates senescent cells via upregulating AMPK-mediated PD-L1 expression.
(ESC congress 2023 2023)

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Education (2)：

2014 - 2018 Niigata University Graduate School of Medical and Dental Sciences Course of Biological Functions and Medical Control
2003 - 2009 Niigata University Faculty of Medicine School of Medicine

Professional career (1)：

医学博士 (新潟大学大学院医歯学総合研究科)

Work history (7)：

2021/04 - 現在 Juntendo University School of Medicine Department of Cardiovascular Biology and Medicine Project Assistant Professor
2018/02 - 2021/03 新潟大学医歯学総合病院循環器内科医員
2018/01 - 2018/01 厚生連佐渡総合病院循環器内科
2014/04 - 2017/12 Niigata University Medical and Dental Hospital, Cardiovascular Medicine
2012/04 - 2014/03 Niigata University Medical and Dental Hospital, Cardiovascular Medicine

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Awards (10)：

2024/06 - 第24回抗加齢医学会総会最優秀演題賞細胞老化関連蛋白GPNMBの血中濃度と個体老化の関連の検証
2020/09 - 第20回抗加齢医学会総会最優秀演題賞老化細胞の選択的除去効果を有する新規薬剤の導出と加齢性疾患への効果の検討
2019/11 - International Heart Journal International Heart Journal Ueda Heart Awards Catecholamine-Induced Senescence of Endothelial Cells and Bone Marrow Cells Promotes Cardiac Dysfunction in Mice
2019/08 - ESC Congress 2019 Basic Science Travel Grant A novel senolytic drug, seno-7284 ameliorates age-related cardiometabolic diseases
2017/12 - 脳心血管抗加齢研究会2017 Young Investigator Aword 慢性的な交感神経シグナルの活性化は骨髄-血管内皮老化を介し心不全を増悪させる

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Association Membership(s) (4)：

日本抗加齢学会 , JAPANESE HEART RHYTHM SOCIETY , The Japanese Circulation Society , THE JAPANESE SOCIETY OF INTERNAL MEDICINE

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