Rchr
J-GLOBAL ID：201801019693602751   Update date: Mar. 09, 2024

Flechsig Holger

フレクシグ ホルガー | Flechsig Holger
Affiliation and department：
Kanazawa University Nano Life Science Institute (WPI-NanoLSI)

About Kanazawa University Nano Life Science Institute (WPI-NanoLSI)


Job title： Assistant Professor
Research field  (3)： Bio-, chemical, and soft-matter physics ,  Biophysics ,  Computational science
Research keywords  (6)： Protein Machines ,  Molecular Motors ,  Biological Evolution ,  Protein dynamics ,  Computational Biology ,  Biophysics
Research theme for competitive and other funds  (20)：
  • 2023 - 2024 Investigation of p53 degradation mechanism by E6AP ubiquitin ligase and E6 protein derived from human papillomavirus.
  • 2023 - 2024 Developing optimized molecular models of integrin/laminin binding by combing systematic mutational analysis with HS-AFM, molecular dynamics simulations and simulated AFM
  • 2021 - 2024 Modelling of myosin V motor dynamics to understand its ATP-less walking along actin filaments under interactive high-speed AFM
  • 2022 - 2023 Investigation of p53 degradation mechanism by E6AP ubiquitin ligase and E6 protein
  • 2022 - 2023 Strategic Research Promotion Program (Core-to-Core Program)
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Papers (37)：
  • Lucky Akter, Holger Flechsig, Arin Marchesi, Clemens M Franz. Observing dynamic conformational changes within the coiled-coil domain of different laminin isoforms by high-speed atomic force microscopy. International Journal of Molecular Sciences. 2024. 25. 4. 1951
  • Romain Amyot, Noriyuki Kodera, Holger Flechsig. Atom Filtering Algorithm and GPU-Accelerated Calculation of Simulation Atomic Force Microscopy Images. Algorithms. 2024. 17. 38
  • Zhongjie Ye, Nicola Galvanetto, Leonardo Puppulin, Simone Pifferi, Holger Flechsig, Melanie Arnd, Cesar Adolfo, Sánchez Triviño, Michael Di Palma, Shifeng Guo, et al. Structural heterogeneity of the ion and lipid channel TMEM16F. Nature Communications. 2024. 15. 110
  • Ayumi Sumino, Takashi Sumikama, Yimeng Zhao, Holger Flechsig, Kenichi Umeda, Noriyuki Kodera, Motoyuki Hattori, Mikihiro Shibata. High-speed AFM reveals fluctuations and dimer splitting of the N-terminal domain of GluA2-γ2. 2023
  • Kazusa Takeda, Holger Flechsig, Ikumi Muro, Romain Amyot, Fuminori Kobayashi, Noriyuki Kodera, Toshio Ando, Hiroki Konno. Structural Dynamics of E6AP E3 Ligase HECT Domain and Involvement of a Flexible Hinge Loop in the Ubiquitin Chain Synthesis Mechanism. Nano Letters. 2023. 23. 11940-11948
ｍore...
MISC (2)：
  • Damien Hall, Holger Flechsig, Takashi Sumikama. Computational biophysics of atomic force microscopy-an IUPAB-sponsored workshop. Biophysical Reviews. 2023. 15. 6. 2041-2044
  • Takashi Sumikama, Damien Hall, Holger Flechsig. Biophysical Reviews Issue Focus call: Computational biophysics of atomic force microscopy. Biophysical Reviews. 2023. 15. 1. 17-18
Books (3)：
  • Computational biophysics of atomic force microscopy-an IUPAB-sponsored workshop
    Biophysical Reviews 2023
  • Biophysical Reviews Issue Focus call: Computational biophysics of atomic force microscopy
    Biophysical Reviews 2023
  • Molecular Motors - Nanoscale engines of the cell and their structurally resolved modeling.
    VHS Publishing 2012 ISBN:9783838134086
Lectures and oral presentations  (28)：
  • Protein dynamics by the combination of high-speed atomic force microscopy and computational modeling
    (The 61st Annual Meeting of the Biophysical Society of Japan 2023)
  • Protein dynamics by the combination of high-speed atomic force microscopy and computational modeling
    (NanoBioCom 2023, Quy Nhon Vietnam 2023)
  • Simulation atomic force microscopy
    (11th Bio-SPM Summer School 2023)
  • Biomolecular modeling to understand nanoprobe measurements
    (WPI Site visit 2023 2023)
  • HFSP progress report
    (HFSP Meeting: Self-organization and biomechanical properties of the endosomal membrane 2022)
ｍore...
Education (2)：
  • 2007 - 2011 Fritz Haber Institute of the Max Planck Society Department of Physical Chemistry
  • 2000 - 2007 Free University Berlin, Department of Physics
Work history (7)：
  • 2018/02 - 現在 Kanazawa University, Nano Life Science Institute (WPI-Nano LSI) Assistant Professor
  • 2017/11 - 2018/01 Ochanomizu Womens University, Department of Information Sciences Researcher (part time)
  • 2017/04 - 2018/01 Hiroshima University, Graduate School of Science Researcher
  • 2015/04 - 2017/03 Hiroshima University, Graduate School of Science Assistant Professor (Faculty)
  • 2014/02 - 2015/03 Hiroshima University, Graduate School of Science Researcher
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Committee career (2)：
  • - 現在 Biophysical Society of Japan
  • - 現在 German Physical Society
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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