Sakamoto Kimitoshi

Affiliation and department：

Research keywords (5)： anaerobic respiratory chain , redox enzyme , rhodoquinone , ubiquinone biosynthesis , respiratory electron transfer chain

Research theme for competitive and other funds (7)：

2020 - 2023 嫌気的呼吸能の付与による、余剰還元力を活用した微生物物質生産系の開拓
2019 - 2022 Identification and analysis of lipophilic ligands for the nuclear receptor essential for planarian sexualization
2015 - 2018 Identification of sex-inducing substances that can trigger the switching from asexual to sexual reproduction in planarians.
2014 - 2017 Reaction mechanism analysis and inhibitor screening of helminthic fumarate quinone reductase
2011 - 2013 Development of the expression system of helminthic mitochondrial quinol-fumarate reductase in bacteria.

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Papers (69)：

Yuta Horie, Makoto Uchikata, Sachie Ueda, Gai Yamahira, Masaru Hashimoto, Kimitoshi Sakamoto, Hiroyuki Ito, Shigeki Hamada. In vitro synthesis of oryzamutaic acid H using recombinant L-lysine ε-dehydrogenase from Agrobacterium tumefaciens. Journal of biotechnology. 2024. 385. 42-48
Kiyono Sekii, Taro Watanabe, Riku Ito, Akitoshi Yoshikawa, Madoka Ichikawa-Seki, Kimitoshi Sakamoto, Kazuya Kobayashi. Fractionation of a sex-inducing substance from flatworms using open-column chromatography and reverse-phase high-performance liquid chromatography. STAR Protocols. 2023. 4. 4
Haruka Nagatani, Yoshiyuki Mae, Miharu Konishi, Motomichi Matsuzaki, Kiyoshi Kita, Fevzi Daldal, Kimitoshi Sakamoto. UbiN, a novel Rhodobacter capsulatus decarboxylative hydroxylase involved in aerobic ubiquinone biosynthesis. FEBS open bio. 2023
Kiyono Sekii, Soichiro Miyashita, Kentaro Yamaguchi, Ikuma Saito, Yuria Saito, Sayaka Manta, Masaki Ishikawa, Miyu Narita, Taro Watanabe, Riku Ito, et al. Sex-inducing effects toward planarians widely present among parasitic flatworms. iScience. 2023. 26. 1. 105776-105776
Atsushi Tashibu, Daniel Ken Inaoka, Kimitoshi Sakamoto, Kenji Murakami, Ferdoush Zannatul, Kiyoshi Kita, Madoka Ichikawa-Seki. Fumarate respiration of Fasciola flukes as a potential drug target. Frontiers in cellular and infection microbiology. 2023. 13. 1302114-1302114

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MISC (2)：

北潔, 坂元君年. 【その時ミトコンドリアは動いた独自の品質管理システムから疾患に迫る】ミトコンドリアのフマル酸呼吸と低酸素適応. 細胞工学. 2010. 29. 5. 455-460
MIZUGUCHI MITSUHIRO, TOYAMA HIROHIDE, ADACHI OSAO, MATSUSHITA KAZUNOBU, SAKAMOTO KIMITOSHI, MIYOSHI HIDEHITO. 酢酸菌のキノヘモプロテインアルコール脱水素酵素におけるユビキノン反応部位のアジドキノン標識法による同定. 生化学. 2001. 73. 8. 868

Lectures and oral presentations (8)：

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Education (2)：

Committee career (1)：

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