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J-GLOBAL ID：201801019978434100   Update date: Nov. 22, 2024

Okuda Hiroaki

オクダ ヒロアキ | Okuda Hiroaki
Affiliation and department：
Osaka Medical and Pharmaceutical University

About Osaka Medical and Pharmaceutical University


Research field  (3)： Neuropathology ,  Neuroanatomy and physiology ,  Anatomy
Research keywords  (4)： 疼痛学 ,  グリア細胞 ,  神経化学 ,  解剖学
Research theme for competitive and other funds  (21)：
  • 2024 - 2027 赤ビート成分ベタニンによる抗炎症作用のメカニズムの解明
  • 2023 - 2027 虚血性筋痛における脊髄神経節マクロファージを介した末梢感作機構の解明
  • 2021 - 2025 機能性胃腸症における胃の痛覚過敏への、CRF2を介した炎症性サイトカインの関与
  • 2023 - 2024 食用ビート成分による潰瘍性大腸炎の緩和作用の解明を介した新規治療法の開発
  • 2021 - 2024 末梢神経系グリア細胞を標的とした痛みの慢性化メカニズムの解明
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Papers (56)：
  • Tatsuhide Tanaka, Ayami Isonishi, Mitsuko Banja, Rikuto Yamamoto, Masaki Sonobe, Emiko Okuda-Ashitaka, Hidemasa Furue, Hiroaki Okuda, Kouko Tatsumi, Akio Wanaka. Dermal macrophages control tactile perception under physiological conditions via NGF signaling. Scientific reports. 2024. 14. 1. 27192-27192
  • Ilia Viktorovich Potapenko, Tatsuya Ishikawa, Hiroaki Okuda, Kiyomi Hori, Noriyuki Ozaki. Chemogenetic inhibition of pain-related neurons in the posterior insula cortex reduces mechanical hyperalgesia and anxiety-like behavior during acute pain. Biochemical and Biophysical Research Communications. 2024
  • Tatsuya Ishikawa, Daisuke Uta, Hiroaki Okuda, Ilia Potapenko, Kiyomi Hori, Toshiaki Kume, Noriyuki Ozaki. Combined Experiments with <i>in Vivo</i> Fiber Photometry and Behavior Tests Can Facilitate the Measurement of Neuronal Activity in the Primary Somatosensory Cortex and Hyperalgesia in an Inflammatory Pain Mice Model. Biological and Pharmaceutical Bulletin. 2024. 47. 3. 591-599
  • Tatsuya Ishikawa, Koshi Murata, Hiroaki Okuda, Ilia Potapenko, Kiyomi Hori, Takafumi Furuyama, Ryo Yamamoto, Munenori Ono, Nobuo Kato, Yugo Fukazawa, et al. Pain-related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety. iScience. 2023. 26. 4. 106332-106332
  • Tatsuhide Tanaka, Hiroaki Okuda, Ayami Isonishi, Yuki Terada, Masahiro Kitabatake, Takeaki Shinjo, Kazuya Nishimura, Shoko Takemura, Hidemasa Furue, Toshihiro Ito, et al. Dermal macrophages set pain sensitivity by modulating the amount of tissue NGF through an SNX25-Nrf2 pathway. Nature immunology. 2023. 24. 3. 439-451
ｍore...
MISC (113)：
  • Development of a new therapy mechanism through elucidation of the alleviating effect of red beet component on ulcerative colitis. 飯島藤十郎記念食品科学振興財団年報. 2024. 39
  • 奥田洋明, 石川達也, 堀紀代美, 尾崎紀之. 慢性痛の発症メカニズムの解明と治療を目指して:中枢と末梢の観点から. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2024. 129th
  • 田中達英, 奥田洋明, 和中明生. Dermal macrophages set pain sensitivity. 月刊臨床免疫・アレルギー科. 2024. 81. 1. 58-63
  • 奥田洋明, 石川達也, 堀紀代美, 尾崎紀之. 末梢神経系におけるHedgehogシグナルの活性化は痛覚過敏の発症に関与する. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
  • 堀紀代美, 奥田洋明, 石川達也, 白石昌武, 中村恒夫, 尾崎紀之. 血管内皮増殖因子のスプライスバリアントVEGF-A165aとVEGF-A165bの量的バランスは下肢虚血に起因する筋の痛覚過敏に関与する. 日本解剖学会総会・全国学術集会抄録集(CD-ROM). 2023. 128th
ｍore...
Patents (3)：
Education (3)：
  • 2003 - 2007 Osaka University Graduate School of Medicine
  • 2001 - 2003 Setsunan University Graduate School of Pharmaceutical Sciences
  • 1997 - 2001 Setsunan University Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences
Professional career (1)：
  • 博士(医学) (大阪大学)
Work history (3)：
  • 2024/04 - 現在 Osaka Medical and Pharmaceutical University
  • 2016/04 - 2024/03 Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine
  • 2007/04 - 2016/03 Nara Medical University
Awards (1)：
  • 2017/03 - 日本解剖学会 奨励賞
Association Membership(s) (4)：
JAPANESE ASSOCIATION FOR THE STUDY OF PAIN ,  JAPANESE SOCIETY OF NEUROLOGY ,  THE JAPANESE SOCIETY FOR NEUROCHEMISTRY ,  THE JAPANESE ASSOCIATION OF ANATOMISTS
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