Rchr
J-GLOBAL ID：201801020079147604
Update date: Apr. 04, 2024
OZAWA SHIN-ICHIRO
オザワ シンイチロウ | OZAWA SHIN-ICHIRO
Affiliation and department：
Job title：
Assistant Professor
Research field (4)：
Pharmaceuticals - chemistry and drug development
, Pharmaceuticals - analytical and physicochemistry
, Structural biochemistry
, Biophysics
Research keywords (7)：
計算化学
, 創薬化学
, 物理系薬学
, インシリコ創薬
, 分子動力学
, 構造生物学
, 生物物理学
Research theme for competitive and other funds (3)：
- 2023 - 2027 Development of knowledge-based computational method for drug discovery targeting cryptic pockets
- 2020 - 2023 Development of novel computational method for identification of druggable cryptic pocket on protein surface
- 2018 - 2020 Development of in silico fragment mapping method for discovery of small-molecule PPI inhibitors
Papers (15)：
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Mitsuru Okuwaki, Shin-Ichiro Ozawa, Shuhei Ebine, Motoki Juichi, Tadanobu Umeki, Kazuki Niioka, Taiyo Kikuchi, Nobutada Tanaka. The stability of NPM1 oligomers regulated by acidic disordered regions controls the quality of liquid droplets. The Journal of Biochemistry. 2023. 174. 5. 461-476
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Yosuke Kaneko, Shin-ichiro Ozawa, Yuiko Sato, Tami Kobayashi, Tatsuaki Matsumoto, Kana Miyamoto, Shu Kobayashi, Kengo Harato, Shuichi Hirono, Morio Matsumoto, et al. The Stat3 inhibitor F0648-0027 is a potential therapeutic against rheumatoid arthritis. Biochemical and Biophysical Research Communications. 2022. 636. Pt 2. 133-140
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Ko Morishita, Yuma Ito, Kazuya Otake, Kenji Takahashi, Megumi Yamamoto, Tatsuya Kitao, Shin-ichiro Ozawa, Shuichi Hirono, Hiroaki Shirahase. Synthesis and Evaluation of a Novel Series of 2,7-Substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline Derivatives as Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonists. Chemical and Pharmaceutical Bulletin. 2021. 69. 4. 333-351
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Ko Morishita, Tomohiro Miike, Shigemitsu Takeda, Masaki Fukui, Yuma Ito, Tatsuya Kitao, Shin-ichiro Ozawa, Shuichi Hirono, Hiroaki Shirahase. (S)-1,2,3,4-Tetrahydroisoquinoline Derivatives Substituted with an Acidic Group at the 6-Position as a Selective Peroxisome Proliferator-Activated Receptor γ Partial Agonist. Chemical and Pharmaceutical Bulletin. 2019. 67. 11. 1211-1224
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Shin-ichiro Ozawa, Miki Takahashi, Noriyuki Yamaotsu, Shuichi Hirono. Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping. Journal of Molecular Graphics and Modelling. 2019. 89. 102-108
ｍore...
MISC (1)：
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Shin-ichiro Ozawa. Discovery of protein-protein interaction inhibitors using in silico fragment mapping method. Monthly Fine Chemical. 2020. 49. 10. 19-24
Lectures and oral presentations (61)：
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Discovery of novel DPP8 inhibitors by fragment-based approach
(2024)
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新規DPP8阻害剤の開発を目的としたフラグメントベースバーチャルスクリーニング
(第51回構造活性相関シンポジウム 2023)
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NPM1の多量体形成制御を介した液滴形成と核小体形成の制御
(第96回日本生化学会大会 2023)
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Discovery of DPP8 inhibitors using in silico fragment mapping method
(IX EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’23) 2023)
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Discovery of DPP8 inhibitors by in silico fragment mapping method
(2023)
ｍore...
Education (3)：
- 2009 - 2013 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 2007 - 2009 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 2003 - 2007 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
- Doctor of Pharmacy (The University of Tokyo)
Work history (1)：
- 2013/04/01 - Kitasato Univversity School of Pharmacy, Research associate
Awards (1)：
- 2010/08 - International Conference on Magnetic Resonance in Biological Systems (ICMRBS) 24th ICMRBS Student Poster Award Development of residue selective cross-saturation method for modeling a large protein-protein complex
Association Membership(s) (2)：
The Pharmaceutical Society of Japan Division of Medicinal Chemistry
, The Pharmaceutical Society of Japan
