Rchr
J-GLOBAL ID：201801020143201243
Update date: Sep. 24, 2024
Yasuhara Takaaki
ヤスハラ タカアキ | Yasuhara Takaaki
Affiliation and department：
Job title：
Professor
Homepage URL (2)：
https://www.rbc.kyoto-u.ac.jp/genome_stress/
,
https://www.rbc.kyoto-u.ac.jp/genome_stress/en/
Research field (4)：
Genomics
, Tumor biology
, Radiology
, Environmental effects of radiation
Research keywords (6)：
DNA damage response
, DNA repair
, Genome stability
, Transcription
, Condensate
, Senescence
Research theme for competitive and other funds (10)：
- 2022 - 2026 Age-related changes in germline cells that cause chromosome translocations
- 2021 - 2026 Investigation of the new factors regulating transcription- associated DNA double-strand break repair
- 2021 - 2025 全ゲノム領域に共通した正確なDNA修復を保証するDSB修復経路選択機構の研究
- 2023 - 2025 Genome instability induced by spatial positions in the nucleus
- 2022 - 2024 A strategy to transform genomic organization and change the gene expression pattern via controlling nucleolar condensates
- 2019 - 2022 Elucidation of the mechanism underlying DNA replication stress response regulating genomic instability
- 2020 - 2022 Chromosome translocations mediated by nuclear condensates
- 2018 - 2021 The roles of R-loop structure in DNA damage signaling and genome
- 2015 - 2017 Mechanism for cancer-related upregulation of the Rad54B-mediated cellular function network
- 2012 - 2015 How Rad54B-mediated network of cellular functions contributes to acquisition of therapy resistance in cancer
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Papers (22)：
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Kie Ozaki, Reona Kato, Takaaki Yasuhara, Yuki Uchihara, Miyako Hirakawa, Yu Abe, Hiroki Shibata, Reika Kawabata-Iwakawa, Aizhan Shakayeva, Palina Kot, et al. Involvement of the splicing factor SART1 in the BRCA1-dependent homologous recombination repair of DNA double-strand breaks. Scientific Reports. 2024. 14. 1
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Peter W. T. Lee, Tatsuya Suwa, Minoru Kobayashi, Hui Yang, Lina R. Koseki, Satoshi Takeuchi, Christalle C. T. Chow, Takaaki Yasuhara, Hiroshi Harada. Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner. British Journal of Cancer. 2024. 131. 1. 37-48
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Taichi Igarashi, Marianne Mazevet, Takaaki Yasuhara, Kimiyoshi Yano, Akifumi Mochizuki, Makoto Nishino, Tatsuya Yoshida, Yukihiro Yoshida, Nobuhiko Takamatsu, Akihide Yoshimi, et al. An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress. Nature Communications. 2023. 14. 4991
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Takaaki Yasuhara, Yu-Hang Xing, Nicholas C. Bauer, Lukuo Lee, Rui Dong, Tribhuwan Yadav, Roy J. Soberman, Miguel N. Rivera, Lee Zou. Condensates induced by transcription inhibition localize active chromatin to nucleoli. Molecular Cell. 2022. 82. 15. 2738-2753
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Yuki Uchihara, Tiara Bunga Mayang Permata, Hiro Sato, Reika Kawabata-Iwakawa, Sayako Katada, Wenchao Gu, Sangeeta Kakoti, Motohiro Yamauchi, Reona Kato, Soehartati Gondhowiardjo, et al. DNA damage promotes HLA class I presentation by stimulating a pioneer round of translation-associated antigen production. Molecular Cell. 2022. 82. 14. 2557-2570
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Books (3)：
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RNA を介したゲノム安定性の維持機構
月刊「アグリバイオ」 2022年 6巻 77-81 2022
-
ゲノム安定性維持機構におけるarcRNA の役割
ニューサイエンス社 月刊「細胞」 2022
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Elucidation of the Mechanism Regulating Transcription Associated Dna Double Strand Break Repair and Its Pathway
Impact 2019 50-51 2019 2019
Lectures and oral presentations (10)：
-
Toward an understanding of how chromosome translocations occur
(Radiation Biology Center Mini-symposium 2023)
-
Genome maintenance by transcription-associated DNA double-strand break repair
(2nd Fukuoka RNA commons 2023)
-
RNAを介したゲノム安定性維持機構
(RNAフロンティアミーティング2023 2023)
-
How Our Genome Is Protected From Mutagenesis
(Asian Young Scientist Fellowship Annual Conference 2023 2023)
-
Condensates induced by nucleolar stresses mediate gene fusion
(19th Ataxia-Telangiectasia workshop(ATW2023) 2023)
ｍore...
Education (2)：
- 2011 - 2015 The University of Tokyo Graduate School of Medicine
- 2007 - 2011 The University of Tokyo The Faculty of Medicine
Professional career (1)：
- PhD (Medicine) (The University of Tokyo)
Work history (7)：
- 2023/07 - 現在 Kyoto University Graduate School of Biostudies Professor
- 2023/04 - 2023/06 The University of Tokyo Isotope Science Center Project Lecturer
- 2021/10 - 2023/03 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Assistant Professor
- 2018/06 - 2021/10 Massachusetts General Hospital Cancer Center Research Fellow
- 2018/06 - 2020/05 Japan Society for the Promotion of Science JSPS Overseas Research Fellow
- 2015/04 - 2018/06 The University of Tokyo Graduate School of Medicine Center for Disease Biology and Integrative Medicine Assitant Professor
- 2012/04 - 2015/03 Japan Society for the Promotion of Science Research Fellow (DC1)
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Awards (8)：
- 2023/05 - Asian Young Scientist Fellowship 2023
- 2023/04 - The Minister of Education, Culture, Sports, Science and Technology The Young Scientists' Award, The Commendation for Science and Technology
- 2018/06 - Japan Society for the Promotion of Science Overseas Research Fellowships
- 2015/12 - The Molecular Biology Society of Japan Best Presenter Award
- 2015/10 - Young Radiation Biologists’ Association of Japan Best Paper Award
- 2015/05 - International Congress of Radiation Research 2015 Young Investigators’ Award
- 2012/04 - Japan Society for the Promotion of Science Research Fellowships for Young Scientist
- 2011/04 - Faculty of Medicine, The University of Tokyo Fellowships for Ph.D.-M.D. Course Trainee
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Association Membership(s) (2)：
THE JAPANESE RADIATION RESEARCH SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
