Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Synthesis of Organic Functional Molecules
About Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Synthesis of Organic Functional Molecules
Research field (3):
Bioorganic chemistry
, Chemical biology
, Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (8):
2021 - 2024 新規核酸貫通構造体の構築とmRNA保護法への展開
2020 - 2022 RNA標的創薬を指向したRNA-小分子間化学シグナル大規模解析技術の展開
2019 - 2022 Development of novel reactive units that activate on higher-order structures of nucleic acids and their application to highly selective inhibitors
2015 - 2020 Development for the functional middle size molecules to the high ordered nucleic acidsstructure
2016 - 2019 Creation of new function of chemically-modified cyclized nucleic acids
2015 - 2017 核酸上を一次元的に動く分子マシンの開発
2014 - 2016 Development of a novel method to control translation by pseudorotaxane formation targeting on RNA
2008 - 2010 RNAの選択的化学修飾を目指した官能基転移能を持つ人工核酸の開発
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Papers (50):
Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito, Fumi Nagatsugi. Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries. Communications Chemistry. 2024
Tamaki Endoh, Sagar Satpathi, Yutong Chen, Saki Matsumoto, Tatsuya Ohyama, Peter Podbevšek, Janez Plavec, Kazumitsu Onizuka, Fumi Nagatsugi, Naoki Sugimoto. Guanidine modification improves functions of natural RNA-targeting alkaloids. New Journal of Chemistry. 2024
Fangjie Lyu, Takashi Tomita, Naoko Abe, Haruka Hiraoka, Fumitaka Hashiya, Yuko Nakashima, Shiryu Kajihara, Fumiaki Tomoike, Zhaoma Shu, Kazumitsu Onizuka, et al. Topological capture of mRNA for silencing gene expression. Chemical communications (Cambridge, England). 2023. 59. 77. 11564-11567
Kazumitsu Onizuka. Creation of unique nucleic acid structures using nucleic acid reaction fields. Journal of Synthetic Organic Chemistry, Japan. 2023. 81. 8. 809-816
Kazuki Kuwahara, Sayaka Yajima, Yuuhei Yamano, Fumi Nagatsugi, Kazumitsu Onizuka. Formation of Direction-Controllable Pseudorotaxane and Catenane Using Chemically Cyclized Oligodeoxynucleotides and Their Noncovalent RNA Labeling. Bioconjugate Chemistry. 2023
Large-scale analysis of small molecule-RNA interactions and RNA alkylation reactions
(The 144th Annual Meeting of the Pharmaceutical Society of Japan Asia Symposium on Pharmaceutical Sciences for the Next Generation: Chemical Biology 2024)
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN
, THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN
, THE JAPAN SOCIETY OF NUCLEIC ACIDS CHEMISTRY
, THE CHEMICAL SOCIETY OF JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN