Rchr
J-GLOBAL ID：201801020159078166   Update date: Sep. 26, 2024

Onizuka Kazumitsu

オニヅカ カズミツ | Onizuka Kazumitsu
Affiliation and department：
Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Synthesis of Organic Functional Molecules

About Tohoku University Institute of Multidisciplinary Research for Advanced Materials Division of Organic- and Bio-materials Research Synthesis of Organic Functional Molecules


Job title： Associate Professor
Homepage URL  (1)： http://www2.tagen.tohoku.ac.jp/lab/nagatsugi/html/index.html
Research field  (3)： Bioorganic chemistry ,  Chemical biology ,  Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds  (8)：
  • 2021 - 2024 新規核酸貫通構造体の構築とmRNA保護法への展開
  • 2020 - 2022 RNA標的創薬を指向したRNA-小分子間化学シグナル大規模解析技術の展開
  • 2019 - 2022 Development of novel reactive units that activate on higher-order structures of nucleic acids and their application to highly selective inhibitors
  • 2015 - 2020 Development for the functional middle size molecules to the high ordered nucleic acidsstructure
  • 2016 - 2019 Creation of new function of chemically-modified cyclized nucleic acids
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Papers (52)：
  • Yutong Chen, Kazumitsu Onizuka, Fumi Nagatsugi. Michael addition-activated alkylation of G-quadruplex DNA with methylamine-protected vinyl-quinazolinone derivatives. Bioorganic & medicinal chemistry letters. 2024. 109. 129855-129855
  • Nadya Soemawisastra, Hidenori Okamura, Ahmed Mostafa Abdelhady, Kazumitsu Onizuka, Mamiko Ozawa, Fumi Nagatsugi. Uracil-selective Cross-linking in RNA and Inhibition of miRNA Function by 2-Amino-6-vinyl-7-deazapurine Deoxynucleosides. ChemBioChem. 2024. e202400417
  • Ryosuke Nagasawa, Kazumitsu Onizuka, Kaoru R. Komatsu, Emi Miyashita, Hirotaka Murase, Kanna Ojima, Shunya Ishikawa, Mamiko Ozawa, Hirohide Saito, Fumi Nagatsugi. Large-scale analysis of small molecule-RNA interactions using multiplexed RNA structure libraries. Communications Chemistry. 2024
  • Tamaki Endoh, Sagar Satpathi, Yutong Chen, Saki Matsumoto, Tatsuya Ohyama, Peter Podbevšek, Janez Plavec, Kazumitsu Onizuka, Fumi Nagatsugi, Naoki Sugimoto. Guanidine modification improves functions of natural RNA-targeting alkaloids. New Journal of Chemistry. 2024. 48. 19. 8529-8533
  • Fangjie Lyu, Takashi Tomita, Naoko Abe, Haruka Hiraoka, Fumitaka Hashiya, Yuko Nakashima, Shiryu Kajihara, Fumiaki Tomoike, Zhaoma Shu, Kazumitsu Onizuka, et al. Topological capture of mRNA for silencing gene expression. Chemical communications (Cambridge, England). 2023. 59. 77. 11564-11567
ｍore...
MISC (3)：
Patents (1)：
  • 核酸内グアニン塩基結合性蛍光色素
Books (2)：
  • 進化を続ける核酸化学 : ゲノム編集、非二重らせん、核酸医薬
    化学同人 2021
  • Middle Molecular Strategy
    2021
Lectures and oral presentations  (67)：
  • RNA標的創薬研究に資する 核酸化学ツール開発
    (第12回 Chem-Bio Joint Seminar 2024 2024)
  • Non-enzymatic abasic site generation in DNA by photo-catalytic reaction
    (ISBC2024 2024)
  • Interstrand crosslinking mediated by 2’-deoxythioguanosine-containg oligonucleotides
    (ISBC2024 2024)
  • Elucidation of RNA-binding selectivity of an aminoglycoside-thiazole orange probe by large-scale analysis and its application to RNA binder screening
    (2024)
  • Large-scale analysis of small molecule-RNA interactions by barcode microarray method
    (ISBC2024 2024)
ｍore...
Professional career (1)：
  • 博士(薬学) (九州大学)
Association Membership(s) (6)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY ,  NUCLEIC ACIDS THERAPEUTICS SOCIETY OF JAPAN ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE JAPAN SOCIETY OF NUCLEIC ACIDS CHEMISTRY ,  THE CHEMICAL SOCIETY OF JAPAN ,  THE PHARMACEUTICAL SOCIETY OF JAPAN
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