Tezuka Kenta

テヅカケンタ | Tezuka Kenta

Affiliation and department：

Research field (4)： Laboratory animal science , Tumor biology , Immunology , Virology

Research theme for competitive and other funds (3)：

2022 - 2025 HTLV-1水平感染者で誘導されるEnv特異的抗体の性状解析
2019 - 2022 Development of the next-generation humanized mouse model for HTLV-1 infection
2016 - 2018 Development of iPSC-based CTL therapy for HTLV-1 infection

Papers (22)：

Koh Nagata, Kenta Tezuka, Madoka Kuramitsu, Naoki Fuchi, Yuri Hasegawa, Isao Hamaguchi, Kiyonori Miura. Establishment of a novel human T-cell leukemia virus type 1 infection model using cell-free virus. Journal of virology. 2024. e0186223
Sho Saito, Satoshi Kutsuna, Imamura Akifumi, Ryota Hase, Rentaro Oda, Junko Terada, Yosuke Shimizu, Yukari Uemura, Yuki Takamatsu, Akemi Yasuhara, et al. Efficacy of convalescent plasma therapy for COVID-19 in Japan: An open-label, randomized, controlled trial. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2023. 29. 9. 869-874
Masayoshi Suzuki, Kenta Tezuka, Takumi Handa, Risa Sato, Hina Takeuchi, Masaki Takao, Mitsutoshi Tano, Yasuo Uchida. Upregulation of ribosome complexes at the blood-brain barrier in Alzheimer's disease patients. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2022. 42. 11. 2134-2150
Yu Sakurai, Himeka Watanabe, Kazuma Nishio, Kohei Hashimoto, Atsuki Harada, Masaki Gomi, Masayoshi Suzuki, Ryotaro Oyama, Takumi Handa, Risa Sato, et al. pH-Responsive Lipid Nanoparticles Achieve Efficient mRNA Transfection in Brain Capillary Endothelial Cells. Pharmaceutics. 2022. 14. 8
Hina Takeuchi, Masayoshi Suzuki, Ryohei Goto, Kenta Tezuka, Holger Fuchs, Naoki Ishiguro, Tetsuya Terasaki, Clemens Braun, Yasuo Uchida. Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs. Pharmaceutical research. 2022. 39. 7. 1393-1413

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MISC (6)：

Emi Ikebe, Akira Kawaguchi, Kenta Tezuka, Shinya Taguchi, Satoshi Hirose, Takashi Matsumoto, Takahiro Mitsui, Kazuyo Senba, Akira Nishizono, Mitsuo Hori, et al. A novel HSP90 inhibitor, 17-DMAG, induces Tax down-regulation and its oral administration to ATL-model mice intervenes against the infiltration property of the ATL-like lymphocytes and provides extended survival period. Retrovirology. 2014. 11(Suppl 1). P44
Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Hidekatu Iha, Jun-ichi Fujisawa. Inhibition of ATL development in humanized mouse model by AZT/IFN treatment. Retrovirology. 2014. 11(Suppl 1). P43
Takaharu Ueno, Runze Xun, Mineki Saito, Kenta Tezuka, Yuetsu Tanaka, Jun-ichi Fujisawa. Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression. Retrovirology. 2014. 11(Suppl 1). P146
Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Jun-ichi Fujisawa. Carrier model of HTLV-1 infection in humanized NOG mice. Retrovirology. 2014. 11(Suppl 1). P42
Kenta Tezuka, Runze Xun, Mami Tei, Takaharu Ueno, Masakazu Tanaka, Norihiro Takenouchi, Jun-ichi Fujisawa. Inverse correlation between Tax and CD25 expressions in HTLV-1 infected CD4 T-cells in vivo. Retrovirology. 2011. 8(Suppl 1). A14

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Patents (2)：

Books (3)：

創薬研究者がこれだけは知っておきたい最新のウイルス学
技術情報協会 2021
臨床免疫・アレルギー科 Vol.75 No.6
科学評論社 2021
臨床血液 Vol.62 No.1
日本血液学会 2021

Lectures and oral presentations (84)：

輸血用血液製剤と血漿分画製剤の安全性確保と安定供給のための新興・再興感染症の研究血液からの重症熱性血小板減少症候群ウイルス等の検出法確立に関する研究
(輸血用血液製剤と血漿分画製剤の安全性確保と安定供給のための新興・再興感染症の研究令和元年度総括・分担研究報告書(Web) 2020)
小胞体ストレス応答を標的とした新規抗HTLV-1薬の開発
(日本生化学会大会(Web) 2020)
STLV-1感染ニホンザルによるHTLV-1標的ウイルス療法の開発に向けた検討
(日本実験動物学会総会講演要旨集(Web) 2020)
組換えVSVによる抗HTLV-1ウイルス療法の開発に向けたSTLV-1感染ニホンザルのHTLV-1感染霊長類モデルへの応用
(日本ウイルス学会学術集会プログラム・予稿集(Web) 2019)
サル感染モデルを用いたHTLV-1治療薬評価に向けた検討
(日本実験動物学会総会講演要旨集(Web) 2019)

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Professional career (1)：

Work history (5)：

2019/03 - 現在 National Institute of Infectious Diseases Department of Safety Research on Blood and Biological Products Senior Researcher
2018/03 - 2019/02 National Institute of Infectious Diseases Department of Safety Research on Blood and Biological Products Researcher
2015/03 - 2018/02 National Institute of Infectious Diseases Department of Safety Research on Blood and Biological Products Fixed-term Researcher
2015/01 - 2015/02 UNITECH Co., Ltd. Animal experiments Senior Researcher
2014/04 - 2015/01 UNITECH Co., Ltd. Animal experiments Researcher

Awards (2)：

2019/08 - The Japanese Society of HTLV-1 and Associated Diseases Young Investigator Award
2013/06 - International Retrovirology Association 16th International Conference on Human Retroviruses: HTLV and Related Viruses, Poster Award

Association Membership(s) (4)：

The International Retrovirology Association , THE JAPAN SOCIETY OF TRANSFUSION MEDICINE AND CELL THERAPY , The Japanese society of HTLV-1 and Associated Diseases , THE JAPANESE SOCIETY FOR VIROLOGY

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