Miki Nagase

ナガセミキ | Miki Nagase

Affiliation and department：

Research field (1)： Anatomy

Research theme for competitive and other funds (20)：

2023 - 2026 Expression regulation and morphological and function analysis of Piezo1 and Piezo2 in the kidney using genetically engineered mice
2022 - 2025 Development of contrast media for postmortem imaging and optimization of the imaging techniques for medical education, and a verification of the educational effects
2022 - 2025 Development of molecular biological treatment of Eustachian tube dysfunction based on aquaporin functional analysis
2021 - 2024 ポドサイトの形態形成と機能制御の基盤となる分子モーターの解析
2020 - 2023 メカノバイオロジーに基づく腎臓病の病態解明と新規診断・治療法の開発

2018 - 2021 Analysis of the properties of pyrrolidone-fixed cadavers and establishment of its application methods for anatomical research, education, and training

2017 - 2020 Elucidation of the molecular basis of mechano-sensing and responding system and its alteration in hypertension

2016 - 2019 腎糸球体ポドサイトのメカノバイオロジーの解明と糸球体内圧評価法の開発

2015 - 2018 Identification of molecules which regulate the podocyte morphology tightly associated with the glomerular filtration.

2014 - 2016 Structure-function association in podocytopathy via Rho family small G proteins

2012 - 2015 Elucidation of mineralocorticoid receptor/ glucocorticoid receptor paradox and its application to kidney disease therapy

2009 - 2014 The mechanism for activation of aldosterone/mineralocorticoid receptor in life style-related diseases

2009 - 2011 Strategy for overcoming chronic kidney disease, focusing on mineralocorticoid receptor

2005 - 2007 Targeting oxidative stress and new therapy in metabolic syndrome

2005 - 2006 Glomerular podocyte injury in lifestyle-related disease : elucidation of its mechanism and establishment of novel therapeutic strategy to inhibit proteinuria

2000 - 2002 Role of oxidized LDL/LOX-1 in the development and progression of renal disease.

2000 - 2001 Molecular Mechanism of the role of oxidized LDL and physical stress in progressive renal disease

2000 - 2001 発生工学を用いた食塩感受性高血圧発症機序及び臓器障害進展の研究

1999 - 2000 ROLE OF LOX-1, A NOVEL OXIDIZED LOW-DENSITY LIPOPROTEIN RECEPTOR.IN THE PROGRESSION OF RENAL INJURY

1993 - 1993 食塩高血圧の昇圧機序における細胞内pHの役割:特に内皮細胞機能について

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Papers (91)：

Miki Nagase, Hikaru Ando, Yoshiaki Beppu, Hidetake Kurihara, Souta Oki, Fumimasa Kubo, Kazuki Yamamoto, Takashi Nagase, Shinya Kaname, Yoshihiro Akimoto, et al. Glomerular endothelial cell receptor ADGRF5 and the integrity of the glomerular filtration barrier. J Am Soc Nephrol. 2024
Satoyuki Ogino, Kei Yoshikawa, Takashi Nagase, Kaori Mikami, Miki Nagase. Roles of the mechanosensitive ion channel Piezo1 in the renal podocyte injury of experimental hypertensive nephropathy. Hypertension Research. 2023
長瀬美樹. MR 拮抗薬と心腎連関. 日腎会誌. 2023. 65. 5. 464-471
Koji Ochiai, Yuki Mochida, Takashi Nagase, Hiroshi Fukuhara, Yoshihiro Yamaguchi, Miki Nagase. Upregulation of Piezo2 in the mesangial, renin, and perivascular mesenchymal cells of the kidney of Dahl salt-sensitive hypertensive rats and its reversal by esaxerenone. Hypertension Research. 2023
Makoto Miyamoto, Miki Nagase, Itaru Watanabe, Hideki Nakagawa, Kanae Karita, Domingos Hiroshi Tsuji, Arlindo Neto Montagnoli, George Matsumura, Koichiro Saito. Excised human larynx in N-vinyl-2-pyrrolidone-embalmed cadavers can produce voiced sound by pliable vocal fold vibration. Anatomical science international. 2022. 97. 4. 347-357

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MISC (78)：

長瀬美樹. アルドステロン/ミネラルコルチコイド受容体(MR)過剰活性化に起因する腎障害と高血圧. 腎と透析. 2023. 95. 5. 619-625
河原崎和歌子, 長瀬美樹. 【腎臓とRAS up to date】Rac1とRAAS. Angiotensin Research. 2013. 10. 4. 226-233
The role of aldosterone in obese kidney injury. 2012. 243. 7. 573-578
河原崎和歌子, 長瀬美樹. 【心腎連関の病態と治療の進歩-心臓と腎臓からみた循環器疾患】アルドステロンと心腎連関. カレントテラピー. 2012. 30. 8. 761-769
上田浩平, 長瀬美樹. 炎症と酸化ストレス・CKD・心疾患 (特集心腎連鎖の克服を目指した糖尿病腎症の治療) -- (心腎連関と各因子・疾患のかかわり). 糖尿病. 2012. 4. 2. 64-74

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Books (6)：

非腫瘍性疾患病理アトラス腎. 大橋健一、小池淳樹、冨田茂樹、原重雄(編集)
文光堂 2022 ISBN:9784830604881
日本臨牀増刊号「高血圧学(上)」 2020年78巻増刊号1(6月発行)
日本臨牀社 2020
臨床検査ガイド : これだけは必要な検査のすすめかた・データのよみかた
文光堂 2020 ISBN:4830611146
疾患に挑むメカノバイオロジー : 循環器、運動器、がん、再生・発生に生体内の力はどうかかわるのか
羊土社 2020 ISBN:9784758103862
人体の細胞生物学 : カラー図解
日本医事新報社 2018 ISBN:9784784932320

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