Awazawa Motoharu

Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research theme for competitive and other funds (4)：

2020 - 2022 Re-understanding of Systemic Metabolism through Skin-mediated Thermal Regulation
2019 - 2022 Research of EDA and its associated molecules
2016 - 2019 Role of MEK/ERK signaling in pancreatic beta cells - to develop a novel treatment strategy for type 2 diaetes
2011 - 2011 アディポネクチン新規受容体の同定と,その抗糖尿病作用の解明

Papers (38)：

Motoharu Awazawa, Maya Matsushita, Ikumi Nomura, Naoki Kobayashi, Miwa Tamura-Nakano, Yuriko Sorimachi, Keiyo Takubo, Kohjiro Ueki. Imeglimin improves systemic metabolism by targeting brown adipose tissue and gut microbiota in obese model mice. Metabolism: clinical and experimental. 2024. 155796-155796
Kotaro Soeda, Takayoshi Sasako, Kenichiro Enooku, Naoto Kubota, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Motoharu Awazawa, Ryotaro Bouchi, Gotaro Toda, Tomoharu Yamada, et al. Gut insulin action protects from hepatocarcinogenesis in diabetic mice comorbid with nonalcoholic steatohepatitis. Nature communications. 2023. 14. 1. 6584-6584
戸田郷太郎, 升田紫, 生島芳子, 荒川直子, 平池勇雄, 小林直樹, 粟澤元晴, 正本庸介, 諏訪内浩紹, 泉田欣彦, et al. 食後に免疫細胞を活性化するシグナルによる糖代謝調節メカニズム. 日本内分泌学会雑誌. 2022. 98. 1. 283-283
Maya Matsushita, Motoharu Awazawa, Naoki Kobayashi, Yoshiko Matsumoto Ikushima, Kotaro Soeda, Miwa Tamura-Nakano, Masafumi Muratani, Kenta Kobayashi, Matthias Blüher, Jens C. Brüning, et al. An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. Cell Chemical Biology. 2022. 29. 4. 680-689.e6
戸田郷太郎, 升田紫, 生島芳子, 荒川直子, 粟澤元晴, 平池勇雄, 小林直樹, 諏訪内浩紹, 正本庸介, 泉田欣彦, et al. 免疫細胞の環境への応答による代謝調節メカニズム. 肥満研究. 2022. 27. Suppl. 344-344

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MISC (6)：

戸田郷太郎, 升田紫, 生島芳子, 荒川直子, 平池勇雄, 小林直樹, 粟澤元晴, 正本庸介, 諏訪内浩紹, 泉田欣彦, et al. 食後に免疫細胞を活性化するシグナルによる糖代謝調節メカニズム. 日本内分泌学会雑誌. 2022. 98. 1. 283-283
生島芳子, 粟澤元晴, 小林直樹, 遅野井祥, 諏訪内浩紹, 守本祐一, 添田光太郎, 足立淳, 村谷匡史, 水上浩哉, et al. Roles of MEK/ERK signaling in pancreatic β cells under insulin resistant status. 糖尿病(Web). 2021. 64. Suppl
Yukiko Okazaki, Kohjiro Ueki, Aya Iwane, Takayoshi Sasako, Michinori Sakada, Toshihiro Umehara, Hirotsugu Suwanai, Masatoshi Kobayashi, Motoharu Awazawa, Naoki Kobayashi, et al. Identification of a Novel Adipokine Involved in the Development of the Metabolic Syndrome. DIABETES. 2013. 62. A542-A542
AMPK and LKB1. Endocrinology, diabetology & metabolism. 2011. 33. 2. 146-154
Masatoshi Kobayashi, Mitsuru Ohsugi, Takayoshi Sasako, Naoki Kobayashi, Miho Suzuki, Kazuma Kaneko, Motoharu Awazawa, Yukiko Okazaki, Kohjiro Ueki, Keiko Horiuchi, et al. Roles of Wilms' tumor 1-associating protein (WTAP) in development of obesity and diabetes. ENDOCRINE JOURNAL. 2010. 57. S423-S423

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Education (2)：

2004 - 2007 The University of Tokyo Faculty of Medicine
1994 - 2000 The University of Tokyo Faculty of Medicine School of Medicine

Work history (4)：

2018/04 - 現在 Research Institute, National Center for Global Health and Medicine Division Chief
2014/05 - 2018/03 Max-Planck Institute Post Doctoral Fellow
2012/04 - 2014/04 The University of Cologne Post Doctoral Fellow
2009/03 - The University of Tokyo Faculty of Medicine University Hospital Metabolic Diseases Assistant Professor

Awards (5)：

2021 - 日本糖尿病学会リリー賞
2019 - 日本糖尿病合併症学会若手研究奨励賞
2011 - 日本肥満糖尿病・動物学会若手研究奨励賞
2011 - 日本内分泌学会若手研究奨励賞
2011 - 日本糖尿病学会若手研究奨励賞

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