Kudo Yuta

クドウユウタ | Kudo Yuta

Affiliation and department：
Job title： Associate Professor
Other affiliations (1)：

Tohoku University Graduate School of Agricultural Science

Homepage URL (1)： http://www.fris.tohoku.ac.jp/researcher/creative/

Research field (1)： Bioorganic chemistry

Research keywords (5)： biosynthesis , LC-MS , structure determination , bioactive compound , natural product chemistry

Research theme for competitive and other funds (8)：

2024 - 2027 多種の放線菌におけるシグナル分子の同定と二次代謝の活性化への応用
2024 - 2025 化合物生産を制御する放線菌シグナル分子の迅速同定法の開発と有用天然化合物の生産への応用
2022 - 2024 Investigation of the biosynthesis of terrestrial tetrodotoxin via new compound screening and metagenomic analysis
2021 - 2023 陸上における神経毒テトロドトキシンの生合成経路の解明
2020 - 2022 Elucidation of the biosynthetic pathway of terrestrial tetrodotoxin via metagenomic analysis

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Papers (33)：

Masato Terauchi, Yuki Komazaki, Atsushi Yoshino, Yuko Cho, Yuta Kudo, Mari Yotsu-Yamashita, Keiichi Konoki. Assay for okadaic acid O-acyl transferase using HPLC-FLD. Bioscience, Biotechnology, and Biochemistry. 2024. 88. 9. 999-1006
Mayu Hakamada, Chihiro Tokairin, Hayate Ishizuka, Kanna Adachi, Toma Osawa, Shiori Aonuma, Ryosuke Hirozumi, Shigeki Tsuchiya, Yuko Cho, Yuta Kudo, et al. Synthesis and Identification of decarbamoyloxySaxitoxins in Toxic Microalgae and their Reactions with the Oxygenase, SxtT, Reveal Saxitoxin Biosynthesis. Chemistry - A European Journal. 2024
Keita Yamaki, Kyoka Sato, Yuta Kudo, Yuko Cho, Keiichi Konoki, Tomohiro Takatani, Osamu Arakawa, Kentaro Kawatsu, Mari Yotsu-Yamsahita. The quite low cross-reactivity of Kawatsu's anti-tetrodotoxin monoclonal antibody to 5,6,11-trideoxytetrodotoxin, 11-nortetrodotoxin-6(S)-ol, and 11-oxotetrodotoxin, the major tetrodotoxin analogues in pufferfish. Toxicon. 2023. 107081-107081
Osamu Chiba, Noriko Shimada, Shutaro Yoshio, Yuta Kudo, Yuko Cho, Mari Yotsu-Yamashita, Keiichi Konoki. State-Dependent Inhibition of Voltage-Gated Sodium Channels in Neuroblastoma Neuro-2A Cells by Arachidonic Acid from Halichondria okadai. Chemical Research in Toxicology. 2022. 35. 11. 1950-1961
Yuji Yaegashi, Yuta Kudo, Nozomi Ueyama, Ken-ichi Onodera, Yuko Cho, Keiichi Konoki, Mari Yotsu-Yamashita. Isolation and Biological Activity of 9-epiTetrodotoxin and Isolation of Tb-242B, Possible Biosynthetic Shunt Products of Tetrodotoxin from Pufferfish. Journal of Natural Products. 2022. 85. 9. 2199-2206

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MISC (18)：

Mari Yotsu-Yamashita, Yuta Kudo, Nozomi Ueyama, Yuji Yaegashi, Yuko Cho, Keiichi Konoki. Prediction of biosynthetic pathway towards pufferfish toxin, tetrodotoxin. KAIYO MANTHLY. 2023. 55. 2. 47-52
Yuta Kudo, Mari Yotsu-Yamashi. Origin, accumulation and proposed biosynthetic pathway of tetrodotoxin in terrestrial amphibian, newts and frogs. KAIYO MANTHLY. 2023. 55. 2. 53-59
沼野聡, 渡邊龍一, 内田肇, 小澤眞由, 松嶋良次, 工藤雄大, 工藤雄大, 山下まり, 鈴木敏之. 二枚貝が含有する麻痺性貝毒の代謝物に関する研究. 日本食品衛生学会学術講演会講演要旨集. 2023. 119th
沼野聡, 渡邊龍一, 内田肇, 小澤眞由, 松嶋良次, 工藤雄大, 工藤雄大, 山下まり, 鈴木敏之. ホタテガイ(Patinopecten yessoensis)における麻痺性貝毒代謝物の蓄積. 日本水産学会大会講演要旨集(CD-ROM). 2023. 2023
MARI YOTSU-YAMASHITA, YUTA KUDO, NOZOMI UEYAMA, CHARLES T. HANIFIN, SATOSHI NUMANO, YUKO CHO, KEIICHI KONOKI. Prediction of biosynthetic pathways of the pufferfish toxin, tetrodotoxin. NIPPON SUISAN GAKKAISHI. 2022. 88. 5. 423-423

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Books (2)：

Progress in the Chemistry of Organic Natural Products, vol 118. Chemical Ecology of the North American Newt Genera Taricha and Notophthalmus
Springer Nature 2022 ISBN:9783030920302
テトロドトキシンはモノテルペン由来か?-有毒イモリから発見した新規環状グアニジン化合物
月刊化学 2016

Lectures and oral presentations (139)：

サキシトキシンの生合成研究から着想を得たdispacamide類の合成研究
(日本農芸化学会東北支部第159回大会 2024)
下痢性貝毒オカダ酸の二枚貝中腸腺内のアシル化酵素の探索
(日本農芸化学会東北支部第159回大会 2024)
サキシトキシン生合成酵素SxtTの異種発現と反応に基づく生合成経路の推定
(日本農芸化学会東北支部第159回大会 2024)
The Origin of Toxins in Amphibians: Focusing on Tetrodotoxin in Newts
(The 2nd NIBB Workshop on Kleptobiology 2024)
放線菌シグナル分子の迅速同定を目指したγ-ブチロラクトン化合物の化学-酵素合成法の構築
(日本生薬学会第70回年会 2024)

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Education (3)：

2013 - 2016 Tohoku University Graduate School of Agriculture Division of Bioscience and Biotechnology for Future Bioindustries Department of Applied Bioorganic Chemistry
2011 - 2013 Tohoku University Graduate School of Agriculture Division of Bioscience and Biotechnology for Future Bioindustries Department of Applied Bioorganic Chemistry
2007 - 2011 Tohoku University Faculty of Agriculture

Professional career (1)：

Ph.D (Agriculture) (Tohoku Univ.)

Work history (11)：

2024/04 - 現在 Osaka University Institute for Protein Research
2024/04 - 現在 Tohoku University Graduate School of Agricultural Science
2024/04 - 現在 Tohoku University Frontier Research Institute for Interdisciplinary Sciences Creative Interdisciplinary Research Division Associate Professor
2022/04 - 現在連携型博士研究人材総合育成システムの構築連携育成対象者
2022/02 - 2024/03 Tohoku University

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Committee career (10)：

2024/04 - 現在東北大学オープンオンライン教育開発推進センター講座企画運営委員会
2024/04 - 現在 FRIS FRIS-URO WG
2024/01 - 現在東北大学学際科学フロンティア研究所 DEI推進WG
2023/04 - 現在東北大学大学院農学研究科冷凍室管理運営委員会
2023/01 - 現在 toxin symposium committee member

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Awards (11)：

2024/10 - 日本生薬学会日本生薬学会第70回年会優秀発表賞(口頭) 放線菌シグナル分子の迅速同定を目指したγ-ブチロラクトン化合物の化学-酵素合成法の構築
2023/03 - Japan Society for Bioscience, Biotechnology, and Agrochemistry Article award Mass spectrometry-guided discovery of new analogs of bicyclic phosphotriester salinipostin and evaluation of their monoacylglycerol lipase inhibitory activity
2022/12 - 日本農芸化学会東北支部日本農芸化学会東北支部奨励賞新規化合物の探索を軸とする二次代謝産物の生合成研究
2022/09 - 毒素シンポジウム毒素シンポジウム奨励賞
2020/09 - American Chemical Society and American Society of Pharmacognosy ACS Editors' Choice Structures of N-Hydroxy-Type Tetrodotoxin Analogues and Bicyclic Guanidinium Compounds Found in Toxic Newts

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Association Membership(s) (7)：

日本水産学会 , 日本生薬学会 , 毒素シンポジウム , American Chemical Society , マリントキシン研究会 , American Society of Pharmacognosy , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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