Takedachi Masahide

タケダチマサヒデ | Takedachi Masahide

Affiliation and department：
Job title： Professor

Research field (1)： Conservative dentistry and endodontics

Research theme for competitive and other funds (30)：

2023 - 2026 組織再生の3要素を統合的に活用した歯周組織再生効果増強への挑戦
2023 - 2026 Cooperative angiogenesis mechanism in three-dimensional periodontal ligament mimetic organoids.
2022 - 2025 次世代型再生医療の開発を目指した幹細胞由来エクソソーム研究の新展開
2022 - 2025 歯周病におけるFPR2シグナルを介した炎症収束機構の解明
2021 - 2024 LAP依存性組織リモデリングによる歯周組織再生医療の新機軸

2021 - 2023 ラマン分光sortingの導入による歯根膜シングルセル解析の高機能化

2020 - 2023 Evaluation of trophic factor activated by 3D intracellular networks.

2020 - 2022 Creation of neo-epigenetic periodontal therapy targeting DNA twist

2019 - 2022 Analysis of cellular hierarchy in the periodontal ligament

2019 - 2021 Elucidation of mechanisms of regeneration of periodontal tissue by mathematical modelling

2019 - 2021 Fabrication of three-dimensional periodontal ligament tissue with nanometer-sized extracellular matrix films and creation of new system to analyze the cell-cell interaction

2018 - 2021 Challenge to the development of new treatments applying the enhancement of periodontal tissue regeneration by controlling stem cell aging

2018 - 2021 Elucidation of stem cell competencies for periodontal tissue regeneration and application to cell transplantation therapy

2017 - 2020 Basic study for immunomodulatory therapy utilizing crosstalk between macrophages and mesenchymal cells toward periodontal tissue regeneration

2017 - 2019 Nano-scale observation of differentiating periodontal ligament cells

2016 - 2019 Application to periodontal tissue regeneration therapy by microcirculatory improvement medicine through non- neuronal cholinergic system

2015 - 2019 Identification of genetic risk factors of aggressive periodontitis by genome wide approach

2016 - 2018 Feasible research for novel periodontal regeneration therapeutics by CRISPR/Cas9

2015 - 2018 Enhancement of stem cell induced-periodontal tissue regeneration by utilizing hypoxia biology

2015 - 2018 A basic study for the development of stem cell-cytokine therapy aimed at the enhancing periodontal tissue regeneration effect.

2015 - 2017 Photonics imaging of cytodifferentiation of periodontal ligament cells

2014 - 2017 The effect of cell-derived microparticles on the homeostasis of periodontal tissue

2014 - 2017 Establishment of ECM related Periodontal medicine

2013 - 2015 Regulation of mechanical stress-induced responses by adenosine in periodontal tissue

2013 - 2015 Raman imaging of osteoblastic mineralization

2012 - 2015 Asymmetric stem cell division in the homeostasis and the disease onset of periodontal tissue

2011 - 2014 A Challenge to the expansion of indications in periodontal tissue regeneration using FGF-2 by analyzing cross talk between signal molecules

2011 - 2012 The role of adenosine to regulate osteoimmunology in inflammatory bone destruction

2011 - 2012 Complexity single cell analysis designed to create a new periodontal regenerative medicine in silico

2008 - 2009 プリンヌクレオシドによる新規歯槽骨代謝制御機構のin vivo解析

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Papers (51)：

竹立匡秀. 歯周組織の理解の深化と幹細胞移植治療への応用. 日本歯周病学会会誌. 2023. 65. 4. 109-116
Masahide Takedachi, Kohsuke Kawasaki, Keigo Sawada, Kazuma Sakura, Mari Murata, Junpei Shimomura, Kazuma Kawakami, Chiaki Morimoto, Koji Miki, Noboru Takeshita, et al. Periodontal Tissue Regeneration by Transplantation of Autologous Adipose Tissue-Derived Multi-Lineage Progenitor Cells With Carbonate Apatite. Cell transplantation. 2023. 32. 9636897231198296-9636897231198296
Keigo Sawada, Junpei Shimomura, Masahide Takedachi, Mari Murata, Chiaki Morimoto, Kohsuke Kawasaki, Kazuma Kawakami, Tomoaki Iwayama, Shinya Murakami. Activation of periodontal ligament cell cytodifferentiation by juxtacrine signaling from cementoblasts. Journal of Periodontology. 2023
Toshie Nagayasu-Tanaka, Jun Anzai, Masahide Takedachi, Masahiro Kitamura, Tatsuhiro Harada, Shinya Murakami. Effects of combined application of fibroblast growth factor (FGF)-2 and carbonate apatite for tissue regeneration in a beagle dog model of one-wall periodontal defect. Regenerative therapy. 2023. 23. 84-93
島袋善夫, 竹立匡秀, 沢田啓吾, 小清水まみ, 品田和子, 浅井晴美, 溝口あゆみ, 林裕子, 塚本明奈, 宮後緑, et al. 歯周炎新分類に基づく診断とメインテナンス期の歯周炎に起因した,およびそれ以外の原因による歯の喪失発生率との関連性. 日本歯周病学会会誌. 2022. 64. 4. 142-157

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MISC (82)：

竹立匡秀. 歯周組織の理解の深化と幹細胞移植治療への応用. 日本歯周病学会会誌(Web). 2023. 65
竹立匡秀. Elucidation of Periodontal Tissue Homeostatic Mechanisms and Development of Stem Cell Transplantation Therapy for Periodontal Tissue Regeneration. 日本歯周病学会会誌(Web). 2023. 65. 4
島袋善夫, 竹立匡秀, 沢田啓吾, 小清水まみ, 西端隆子, 岩山智明, 藤原千春, 村上伸也. 歯周炎新分類に基づく診断とメインテナンス期の歯周病に関連した歯の喪失未発生者率との関連性. 日本歯科保存学雑誌. 2022. 65. 1. 64-77
川嵜公輔, 竹立匡秀, 沢田啓吾, 下村純平, 村田真里, 河上和馬, 三木康史, 竹下登, 佐倉千萬, 松山晃文, et al. 炭酸アパタイトを足場材とした脂肪組織由来多系統前駆細胞の自己移植による歯周組織再生効果. 日本再生医療学会総会(Web). 2022. 21st
島袋善夫, 島袋善夫, 竹立匡秀, 沢田啓吾, 小清水まみ, 西端隆子, 岩山智明, 藤原千春, 村上伸也. Association of the New Periodontitis Classification with Non-incidence Rate of Periodontitis-related Tooth Loss during Maintenance. 日本歯科保存学雑誌(Web). 2022. 65. 1

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Lectures and oral presentations (1)：

炎症歯根膜におけるPLAP-1の発現
(第62回春季日本歯周病学会 2018)

Education (2)：

2000 - 2004 Osaka University 歯学研究科
1994 - 2000 Osaka University 歯学部

Work history (7)：

2024 - 現在 Osaka University Graduate School of Dentistry Professor
2017 - 2024 大阪大学歯学部附属病院講師
2011 - 2017 大阪大学大学院歯学研究科助教
2009 - 2011 日本学術振興会特別研究員
2008 - 2009 大阪大学歯学部附属病院医員

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Awards (1)：

2022/09 - 日本歯周病学会学術賞

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