Rchr
J-GLOBAL ID：201801020757097264
Update date: Feb. 01, 2024
Saito Yuichiro
サイトウ ユウイチロウ | Saito Yuichiro
Research field (1)：
Genetics
Research keywords (5)：
タンパク質分解
, ゲノム編集
, DNA修復
, 相同組換え
, Genome Instability
Research theme for competitive and other funds (1)：
- 2021 - 2023 複製ストレス下で機能する組換えDNA複製の制御機構の解明
Papers (17)：
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Wenpeng Liu, Yuichiro Saito, Jessica Jackson, Rahul Bhowmick, Masato T Kanemaki, Alessandro Vindigni, David Cortez. RAD51 bypasses the CMG helicase to promote replication fork reversal. Science (New York, N.Y.). 2023. 380. 6643. 382-387
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Yuichiro Saito, Venny Santosa, Kei-ichiro Ishiguro, Masato T Kanemaki. MCMBP promotes the assembly of the MCM2-7 hetero-hexamer to ensure robust DNA replication in human cells. eLife. 2022. 11
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Yuichiro Saito, Masato T Kanemaki. Targeted Protein Depletion Using the Auxin-Inducible Degron 2 (AID2) System. Current protocols. 2021. 1. 8. e219
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Aisha Yesbolatova, Yuichiro Saito, Naomi Kitamoto, Hatsune Makino-Itou, Rieko Ajima, Risako Nakano, Hirofumi Nakaoka, Kosuke Fukui, Kanae Gamo, Yusuke Tominari, et al. The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice. Nature communications. 2020. 11. 1. 5701-5701
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Lotte P Watts, Toyoaki Natsume, Yuichiro Saito, Javier Garzon, Qianqian Dong, Lora Boteva, Nick Gilbert, Masato T Kanemaki, Shin-Ichiro Hiraga, Anne D Donaldson. The RIF1-long splice variant promotes G1 phase 53BP1 nuclear bodies to protect against replication stress. eLife. 2020. 9
ｍore...
MISC (2)：
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Akihiro Kato, Hiromi Yanagihara, Yuichiro Saito, Zhou Hui, Junya Kobayashi, Kenshi Komatsu. Roles of NBS1 in radiation responses and the initiation of translesional DNA synthesis. DNA REPAIR. 2015. 28. 142-142
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Kobayashi J, Mashimo T, Fuj imoto H, Saito y, Komatsu K. Regulation of DNA double-strand break repair through \nDSB-end resection by Exol. Gordon Research Conference “Mammalian DNA repair"2013 年2 月, Ventura, USA. 2013
Books (2)：
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新世代オーキシンデグロンAID2法による高効率タンパク質分解
羊土社 2021 ISBN:9784758125505
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オーキシンデグロン法によるプロテインノックダウン(実験医学2020年9月号)
実験医学 2020
Lectures and oral presentations (6)：
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MCM8/9は非典型的DNA合成を促進してゲノム恒常性維持に機能する
(日本分子生物学会 第42回大会 2019)
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A dual role of NBS1 in homologous recombination repair of radiation-induced double-strand breaks
(6th US-Japan DNA Repair Meeting 2017)
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相同組換え活性の線量依存的抑制機構
(日本放射線影響学会 第59回大会 2016)
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Dose-dependent regulation of two rejoining pathways for DNA double-strand breaks
(30th RBC-NIRS International Symposium 2015)
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放射線照射による相同組換え修復能の“飽和”と細胞制御機構
(日本放射線影響学会 第57回大会 2014)
ｍore...
Education (3)：
- 2012 - 2015 Kyoto University
- 2010 - 2012 Tokyo Metropolitan University
- 2005 - 2010 Tokyo Metropolitan University Faculty of Urban Liberal Arts Faculty of Urban Liberal Arts
Professional career (1)：
Work history (2)：
- 2018/04 - 2022/07 National Institute of Genetics
- 2015/04 - 2018/07 Kyoto University Radiation Biology Center Post doctor
Awards (3)：
- 2018/04 - (公財)放射線影響協会 放射線影響研究奨励賞
- 2016/10 - 日本放射線影響学会 第59回大会 優秀発表賞
- 2012/03 - 首都大学東京 修士論文賞
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