Rchr
J-GLOBAL ID：201801020797918465
Update date: Jun. 20, 2024
Abe-Chayama Hiromi
Abe-Chayama Hiromi
Affiliation and department：
Research field (1)：
Infectious disease
Research theme for competitive and other funds (4)：
- 2022 - 2025 B型肝炎ウイルス持続感染の完治を目指すHBV特異的Tscmを用いた新規治療の探索
- 2021 - 2024 ヒト肝細胞キメラマウスモデルとヒト組織学的進展例材料を用いたNASHの研究
- 2017 - 2020 Establishment of highly safe gene therapy without usage of double stranded DNA
- 2014 - 2017 Novel animal models for hereditary diseases using human hepatocytes transplanted chimeric mice and vaculovirus
Papers (142)：
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Hiromi Abe-Chayama, Takakazu Kawase, Tatsuo Ichinohe, Yuji Ishida, Chise Tateno, Makoto Hijikata, Kazuaki Chayama. Hepatitis B virus-specific human stem cell memory T cells differentiate into cytotoxic T cells and eradicate HBV-infected hepatocytes in mice. FEBS letters. 2024. 598. 11. 1354-1365
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Grace Naswa Makokha, Kazuaki Chayama, C Nelson Hayes, Hiromi Abe-Chayama, Maidina Abuduwaili, Makoto Hijikata. Deficiency of SCAP inhibits HBV pathogenesis via activation of the interferon signaling pathway. Virology. 2023. 585. 248-258
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Takuro Uchida, Michio Imamura, C Nelson Hayes, Yosuke Suehiro, Yuji Teraoka, Kazuki Ohya, Hiroshi Aikata, Hiromi Abe-Chayama, Yuji Ishida, Chise Tateno, et al. HBV with precore and basal core promoter mutations exhibits a high replication phenotype and causes ER stress-mediated cell death in humanized liver chimeric mice. Hepatology (Baltimore, Md.). 2023
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Takuro Uchida, Yuji Teraoka, Michio Imamura, Hiromi Abe-Chayama, Grace Naswa Makokha, Clair Nelson Hayes, Hiroshi Aikata, Satoko Hamamura, Yuji Ishida, Chise Tateno, et al. A novel cDNA-uPA/SCID/Rag2-/- /Jak3-/- mouse model for hepatitis virus infection and reconstruction of human immune system. Journal of viral hepatitis. 2022. 30. 3. 262-272
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Yosuke Suehiro, Masataka Tsuge, Mio Kurihara, Takuro Uchida, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Grace Naswa Makokha, Takashi Nakahara, Eisuke Murakami, et al. HBV upregulates TRAIL-R3 expression in hepatocytes for escaping both cell apoptosis and suppression of their replication by TRAIL. The Journal of infectious diseases. 2022
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MISC (78)：
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Yuji Teraoka, Michio Imamura, Takuro Uchida, Kazuki Ohya, Mitsutaka Osawa, Kei Morio, Hatsue Fujino, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, et al. PERMISSION OF HEPATITIS B VIRUS INFECTION IN Jak3KORag2KO MOUSE. HEPATOLOGY. 2019. 70. 617A-617A
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Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. GENETIC POLYMORPHISM OF IP-10, NOT IFNL4 OR HLA-DPS, AFFECTS LIVER INFLAMMATION IN CHRONIC HEPATITIS B PATIENTS. HEPATOLOGY. 2019. 70. 412A-413A
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Daiki Miki, Takashi Nakahara, Eisuke Murakami, Hiromi Abe-Chayama, Hatsue Fujino, Atsushi Ono, Masami Yamauchi, Tomokazu Kawaoka, Masataka Tsuge, Akira Hiramatsu, et al. ASSOCIATION OF FNDC5, PNPLA3 AND TM6SF2 POLYMORPHISMS WITH HEPATIC STEATOSIS IN NAFLD PATIENTS. HEPATOLOGY. 2019. 70. 1050A-1051A
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Daiki Miki, Yumi Shimomura, Nelson Hayes, Hiromi Abe-Chayama, Hatsue Fujino, Maiko Numba, Takashi Nakahara, Atsushi Ono, Eisuke Murakami, Masami Yamauchi, et al. A COMPREHENSIVE ANALYSIS OF A WIDE RANGE OF LIVER DISEASES BY 16S rRNA SEQUENCING REVEALS CHARACTERISTIC PATTERNS OF GUT MICROBIOTA IN EACH ETIOLOGY. HEPATOLOGY. 2019. 70. 1163A-1164A
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Daiki Miki, Masataka Tsuge, Hiromi Abe-Chayama, Nelson Hayes, Hatsue Fujino, Grace Naswa Makokha, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Masami Yamauchi, et al. INDEPENDENT IMPACT OF POLYMORPHISM IN IRF5 AS WELL AS STAT4 ON HBV-RELATED HEPATOCARCINOGENESIS. HEPATOLOGY. 2019. 70. 1190A-1190A
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Professional career (1)：
Awards (2)：
- 2014/10 - 日本消化器病学会 Bristol-Myers Award
- 2009/06 - 日本肝臓学会 海外研修スポンサーシップ2009
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