Ono Chikako

Affiliation and department：

Research field (1)： Virology

Research theme for competitive and other funds (5)：

2021 - 2024 SARS-CoV-2増殖におけるマイクロRNAの機能解析
2021 - 2024 Promotion of emerging and re-emerging virus research using high-speed reverse genetics
2018 - 2021 Mechanistic analysis of persistent infection of HCV in non-hepatic cells
2015 - 2017 Characterization of adapted HCV that can replicate efficiently in non-hepatic cells
2012 - 2015 Establishment of mouse infection model of HCV

Papers (77)：

Itsuki Anzai, Junso Fujita, Chikako Ono, Yoichiro Kosaka, Yuki Miyamoto, Shintaro Shichinohe, Kosuke Takada, Shiho Torii, Shuhei Taguwa, Koichiro Suzuki, et al. Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2 spike receptor-binding domain. Microbiology spectrum. 2024. e0365523
Atsushi Kawai, Nagisa Tokunoh, Eigo Kawahara, Shigeyuki Tamiya, Shinya Okamura, Chikako Ono, Jessica Anindita, Hiroki Tanaka, Hidetaka Akita, Sho Yamasaki, et al. Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses. The Journal of clinical investigation. 2023. 133. 23
Rahmi Dianty, Junki Hirano, Itsuki Anzai, Yuta Kanai, Tsuyoshi Hayashi, Masae Morimoto, Chikako Kataoka-Nakamura, Sakura Kobayashi, Kentaro Uemura, Chikako Ono, et al. Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation. Frontiers in microbiology. 2023. 14. 1284274-1284274
Nagisa Tokunoh, Shigeyuki Tamiya, Masato Watanabe, Toru Okamoto, Jessica Anindita, Hiroki Tanaka, Chikako Ono, Toshiro Hirai, Hidetaka Akita, Yoshiharu Matsuura, et al. A nasal vaccine with inactivated whole-virion elicits protective mucosal immunity against SARS-CoV-2 in mice. Frontiers in immunology. 2023. 14. 1224634-1224634
Anastasia Armimi, Afina Firdaus Syuaib, Katherine Vanya, Marselina Irasonia Tan, Dessy Natalia, David Virya Chen, Chikako Ono, Yoshiharu Matsuura, Anita Artarini. SARS-CoV-2 Neutralization Assay System using Pseudo-lentivirus. Indonesian Biomedical Journal. 2023. 15. 2. 179-184

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MISC (4)：

鈴木孝一朗, 鈴木孝一朗, 小野慎子, 朴貞玉, 高橋美恵, 川崎淳, 松浦善治. SARS-CoV-2pseudovirusを利用した中和抗体評価系の開発. 日本衛生検査所協会学術研究発表会全国大会抄録集(Web). 2023. 29th
Sujin Kang, Toshio Tanaka, Hitomi Inoue, Chikako Ono, Shoji Hashimoto, Yoshiyuki Kioi, Hisatake Matsumoto, Hiroshi Matsuura, Tsunehiro Matsubara, Kentaro Shimizu, et al. COVID-19 induces lower extent of cytokines, but damages vascular endothelium by IL-6 signaling. Proceedings of the National Academy of Sciences of the United States of America. 2021. 118. 21
Chikako Ono, Toru Okamoto, Takayuki Abe, Yoshiharu Matsuura. Baculovirus as a tool for gene delivery and gene therapy. Viruses. 2018. 10. 9
Kari J. Airenne, Yu Chen Hu, Thomas A. Kost, Richard H. Smith, Robert M. Kotin, Chikako Ono, Yoshiharu Matsuura, Shu Wang, Seppo Ylä-Herttuala. Baculovirus: An insect-derived vector for diverse gene transfer applications. Molecular Therapy. 2013. 21. 4. 739-749

Lectures and oral presentations (76)：

Suppression of SARS-CoV-2 propagation by siRNA targeting the stem-loop struc tures in the 5'UTR
(The 21st Awaji International Forum on Infection and Immunity 2023)
SARS-CoV-2マウス感染モデルの作製
(ムーンショット目標2×7技術交流会 2023)
Suppression of SARS-CoV-2 propagation by siRNA targeting the stem-loop structures in the 5'UTR
(ASV2023 2023)
SARS-CoV-2に対する抗ウイルス活性を有する海洋天然物の探索と作用機序解明
(日本薬学会第143年会 2023)
新型コロナウイルス感染マウスにおける宿主応答解析
(第69回日本ウイルス学会学術集会 2022)

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