Morihara Takashi

モリハラタカシ | Morihara Takashi

Affiliation and department：
Other affiliations (1)：

大阪大学精神医学

Homepage URL (1)： http://www.med.osaka-u.ac.jp/introduction/research/endowed/precision-medicine-for-dementia

Research field (5)： Psychiatry , Medical biochemistry , Pathobiochemistry , Neuroscience - general , Basic brain sciences

Research keywords (9)：診断マーカー , 創薬 , 老年精神病 , Omics , 疾患モデル動物 , genetics , Dementia , Fluid Biomarker , Alzheimer's Disease

Research theme for competitive and other funds (20)：

2017 - 2020 Research to elucidate novel molecular mechanism in Alzheimer's disease
2016 - 2019 Study of mechanism of neurodegeneration and abnoraml protein deposition in FTLD
2015 - 2018 The effects of phosphorylation on degradative processes of abnormally accumulated intracellular protein in dementia
2014 - 2018 Alzheimer disease modifier gene: Identification by novel transcriptions and functional analysis
2012 - 2015 The analysis of neurodegenerative processes and changes of protein interaction of tau by mutation.

2012 - 2015 Pathogenesis of tauopathies in terms of protein quality control mechanism

2012 - 2015 The analysis of regulatory mechanisms of degradation/aggregation of abnormally accumulated protein in fontotemporal dementia brain.

2011 - 2013 Identification of modifier genes of Alzheimer's disease amyloid pathology using a mouse-to-human translational approach

2009 - 2011 The investigating the molecular mechanisms of cognitive impairment due to cancer chemotherapy and its prevention

2009 - 2011 The mechanisms of aggregation, accumulation and degradation of the genetically causative protein related to familial dementia diseases

2008 - 2010 Involvement of interaction between RNA and protein in neurodegenerative mechanisms in dementia

2008 - 2010 Anti-inflammatory effects on amyloid vaccination therapy by NSAID : a development of Alzheimer disease therapy

2008 - 2010 Application of an ER chaperone inducer for Alzheimer disease

2005 - 2009 Genetic study on Alzheimer Disease

2007 - 2008 The examination of interaction between risk factors for dementia in cerebrovascular diseases and Alzheimer's disease-related factors

2007 - 2008 Discrepancy between regional blood flow and cerebral protein synthesis in patients with Alzheimer's disease

2007 - 2008 Involvement of protein s coded by causative genes for familial dementia and ubiquitin system in neurodegenerative mechanisms

2006 - 2007 The mechanisms of anti-Alzheimer dicaam effects by NSAIDs

2006 - 2007 Study on involvement of of tau-binding factors in neurodegeneration

2005 - 2006 Analysis of sequential endoproteolytic process of beta-APP to establish novel therapeutic interventions

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Papers (95)：

大藏裕平, 佐竹祐人, 末廣聖, 梅田寿美代, 繁信和恵, 工藤喬, 鈴木由貴, 高橋励, 森悦朗, 橋本衛, et al. Lecanemab One Osaka Project LooPの取り組みについて. Dementia Japan. 2024. 38. 4. 684-684
宮本哲愼, 森康治, 赤嶺祥真, 魚住亮太, 後藤志帆, 近藤志都子, 梅田寿美代, 佐竹祐人, 末廣聖, 鐘本英輝, et al. 大阪大学精神科認知症コホートにおけるNOTCH2NLC遺伝子のGGCリピート長解析. Dementia Japan. 2024. 38. 4. 691-691
Masataka Kikuchi, Justine Viet, Kenichi Nagata, Masahiro Sato, Geraldine David, Audic Yann, Michael A. Silverman, Mitsuko Yamamoto, Hiroyasu Akatsu, Yoshio Hashizume, et al. Gene-gene functional relationships in Alzheimer’s disease: CELF1 regulates KLC1 alternative splicing. Biochemical and Biophysical Research Communications. 2024. 150025-150025
Yuto Satake, Hideki Kanemoto, Shiho Gotoh, Shoshin Akamine, Takashi Suehiro, Keiko Matsunaga, Eku Shimosegawa, Kenji Yoshiyama, Takashi Morihara, Kohji Mori, et al. Cerebrospinal fluid amyloid beta with amyloid positron emission tomography concordance rates in a heterogeneous group of patients including late-onset psychotic disorders: a retrospective cross-sectional study. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society. 2023
Yuto Satake, Hideki Kanemoto, Daiki Taomoto, Takashi Suehiro, Fuyuki Koizumi, Shunsuke Sato, Tamiki Wada, Keiko Matsunaga, Eku Shimosegawa, Shiho Gotoh, et al. Characteristics of very late-onset schizophrenia-like psychosis classified with the biomarkers for Alzheimer's disease: a retrospective cross-sectional study. International psychogeriatrics. 2023. 1-14

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MISC (140)：

宮本哲愼, 森康治, 赤嶺祥真, 魚住亮太, 後藤志帆, 近藤志都子, 梅田寿美代, 佐竹祐人, 末廣聖, 鐘本英輝, et al. 大阪大学精神科認知症コホートにおけるNOTCH2NLC遺伝子のGGCリピート長解析. Dementia Japan. 2024. 38. 4
大藏裕平, 佐竹祐人, 末廣聖, 梅田寿美代, 繁信和恵, 繁信和恵, 工藤喬, 鈴木由貴, 高橋励, 森悦朗, et al. Lecanemab One Osaka Project:LooPの取り組みについて. Dementia Japan. 2024. 38. 4
佐竹祐人, 鐘本英輝, 垰夲大喜, 小泉冬木, 末廣聖, 佐藤俊介, 和田民樹, 吉山顕次, 後藤志帆, 森康治, et al. アルツハイマー病バイオマーカー陽性のVLOSLPの特徴. Dementia Japan. 2022. 36. 4
永田健一, 高橋美華, 松葉由紀夫, 森原剛史, 西道隆臣. ゲノム編集技術が切り拓く神経内科学ゲノム編集技術によるアルツハイマー病の保護的バリアントの探索. 臨床神経学. 2019. 59. Suppl. S81-S81
森原剛史, 永田健一, 赤津裕康, LUC Paillard, 池田学. 認知症のプレシジョン医療実現に向けて-疾患再分類,層別化マーカーと血液コアマーカー-. 老年精神医学雑誌. 2019. 30. 増刊II. 131-131

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Books (7)：

国際・未来医療学-健康・医療イノベーション
大阪大学出版会 2017
NICE 疾病と治療III
南江堂 2010
新老年学第3版
東京大学出版会 2010
絵で見る心の保健室
アルタ出版 2007
心の医学新書「心のサイエンスこの10年のあゆみ」
メディカルレビュー社(大阪) 2006

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Education (2)：

1987 - 1993 Osaka University Faculty of Medicine Medical School
大阪大学大学院医学研究科内科系専攻博士課程

Professional career (1)：

医学博士 (大阪大学)

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