Hiraoka Kei

Affiliation and department：

Research field (4)： Tumor diagnostics and therapeutics , Virology , Respiratory surgery , General surgery, pediatric surgery

Research keywords (3)： retrovirus , cancer , gene therapy

Research theme for competitive and other funds (5)：

2018 - 2020 増殖型レトロウイルスを用いた遺伝子治療を応用した膵癌の新規治療戦略
2018 - 2020 増殖型レトロウイルスベクターを用いた肺癌に対する新規遺伝子治療の開発
2018 - 2020 膵癌におけるバイオマーカーの探索および新規治療法の開発
2016 - 2019 放射線増強効果をもつプロドラッグ遺伝子治療システムによる新規膠芽腫治療法の開発
2014 - 2016 Retroviral Replicating Vector (RRV)- Mediated Prodrug-Activator Gene Therapy for Pancreatic Cancer

Papers (35)：

Kazuho Inoko, Kei Hiraoka, Akihito Inagaki, Mizuna Takahashi, Toshihiro Kushibiki, Koji Hontani, Hironobu Takano, Shoki Sato, Shintaro Takeuchi, Toru Nakamura, et al. Therapeutic activity of retroviral replicating vector-mediated prodrug activator gene therapy for pancreatic cancer. Cancer Gene Therapy. 2018. 1-12
Kei Hiraoka, Akihito Inagaki, Yuki Kato, Tiffany T. Huang, Leah A. Mitchell, Shuichi Kamijima, Masamichi Takahashi, Hiroshi Matsumoto, Katrin Hacke, Carol A. Kruse, et al. Retroviral replicating vector-mediated gene therapy achieves long-term control of tumor recurrence and leads to durable anticancer immunity. NEURO-ONCOLOGY. 2017. 19. 7. 918-929
Leah A. Mitchell, Fernando Lopez Espinoza, Daniel Mendoza, Yuki Kato, Akihito Inagaki, Kei Hiraoka, Noriyuki Kasahara, Harry E. Gruber, Douglas J. Jolly, Joan M. Robbins. Toca 511 gene transfer and treatment with the prodrug, 5-fluorocytosine, promotes durable antitumor immunity in a mouse glioma model. NEURO-ONCOLOGY. 2017. 19. 7. 930-939
Yoshiyuki Matsumura, Kei Hiraoka, Keidai Ishikawa, Yasuhito Shoji, Takehiro Noji, Koji Hontani, Tomoo Itoh, Toru Nakamura, Takahiro Tsuchikawa, Toshiaki Shichinohe, et al. CD40 Expression in Human Esophageal Squamous Cell Carcinoma Is Associated with Tumor Progression and Lymph Node Metastasis. ANTICANCER RESEARCH. 2016. 36. 9. 4467-4475
Hironobu Takano, Toru Nakamura, Takahiro Tsuchikawa, Toshihiro Kushibiki, Kouji Hontani, Kazuho Inoko, Mizuna Takahashi, Shoki Sato, Hirotake Abe, Shintaro Takeuchi, et al. Inhibition of Eph receptor A4 by 2,5-dimethylpyrrolyl benzoic acid suppresses human pancreatic cancer growing orthotopically in nude mice. ONCOTARGET. 2015. 6. 38. 41063-41076

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Education (1)：

- 2002 Hokkaido University Graduate School of Medicine

Professional career (1)：

医学博士 (北海道大学)

Work history (3)：

2014 - 現在 Hokkaido University
2009 - 2012 University of California at Los Angeles Department of Medicine Assistant Researcher
2003 - 2007 University of California at Los Angeles Department of Medicine Postdoctoral Researcher

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