Research keywords (11)：
Neurodegenerative diseases
, Motor neuron diseases
, iPSCs
, GEF
, Small G proteins
, Rab
, Golgi apparatus
, amphisome
, Early endosome
, ALS2
, ALS
Research theme for competitive and other funds (14)：
2023 - 2028 ヒト骨格筋オルガノイドを活用した低酸素依存性マイオカインの網羅的探索と評価
2023 - 2028 ヒト骨格筋オルガノイドを活用した低酸素依存性マイオカインの網羅的探索と評価
2024 - 2027 Elucidation of the molecular mechanisms of selective neurodegeneration focusing on the cell-type-specific resilience regulatory systems
2022 - 2025 生理的機能を有するALS細胞モデルの構築とその病態解析
2020 - 2023 A new drug-delivery method to the central nervous system: study on novel proteins that regulate drug-permeability in the blood-brain barrier
2019 - 2023 An ALS2-linked functional cellular network-based study on molecular mechanisms of selective upper motor neuron degeneration in ALS
2019 - 2022 Analysis of the pathogenic mechanism of neurodegenerative diseases focusing on the functional disruption of early endosomes
2014 - 2017 Molecular mechanism for the maintenance of proteostasis in motor neurons
2013 - 2016 Establishment and Characterization of iPS cell lines from Japanese ALS2 patients
2014 - 2016 運動ニューロンの恒常性維持に関わる分子機構の解明
2010 - 2015 sex differences regulated by W- and Y-sex chromosomes
2009 - 2011 Analysis of ALS2 function in motor neurons form common marmoset
2004 - 2006 筋萎縮性側索硬症2型原因遺伝子産物、ALS2の分子機能解析と制御因子の同定
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Papers (49)：
Nami Motosugi, Akiko Sugiyama, Asako Otomo, Yuka Sakata, Takuma Araki, Shinji Hadano, Natsuhiko Kumasaka, Atsushi Fukuda. Effect of PCDH19 missense mutations on cell-to-cell proximity and neuronal development under heterotypic conditions. PNAS nexus. 2024. 3. 3. pgae060
Kai Sato, Kyoko Suzuki-Utsunomiya, Shun Mitsui, Suzuka Ono, Kento Shimakura, Asako Otomo, Shinji Hadano. Central nervous system specific high molecular weight ALS2/alsin homophilic complex is enriched in mouse brain synaptosomes. Biochemical and Biophysical Research Communications. 2023. 638. 168-175
Nami Motosugi, Akiko Sugiyama, Chisa Okada, Asako Otomo, Akihiro Umezawa, Hidenori Akutsu, Shinji Hadano, Atsushi Fukuda. De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs. Cell Reports Methods. 2022. 100352-100352
Matteo Rossi Sebastiano, Giuseppe Ermondi, Kai Sato, Asako Otomo, Shinji Hadano, Giulia Caron. Personalized Treatment for Infantile Ascending Hereditary Spastic Paralysis Based on In Silico Strategies. Molecules (Basel, Switzerland). 2022. 27. 20
Shun Mitsui, Asako Otomo, Kai Sato, Masahito Ishiyama, Kento Shimakura, Chisa Okada-Yamaguchi, Eiji Warabi, Toru Yanagawa, Masashi Aoki, Hui-Fang Shang, et al. SQSTM1, a protective factor of SOD1-linked motor neuron disease, regulates the accumulation and distribution of ubiquitinated protein aggregates in neuron. Neurochemistry international. 2022. 158. 105364-105364
OTOMO Asako, OTOMO Asako, NISHIJIMA Keiko, MURAKAMI Yuta, ISHIKAWA Mitsuru, KIMURA Hiroshi, KIMURA Hiroshi, HADANO Shinji, HADANO Shinji. Evaluation of an FUS-linked ALS cellular model using the microfluidic cell culture system. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
SHIMAKURA Kento, YAMAGUCHI Chisa, YUDAHIRA Haruka, OKA Akira, OTOMO Asako, HADANO Shinji. Spatiotemporal dynamics of SQSTM1 using a photoconvertible fluorescent protein Dendra2. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
村上裕太, WANG Bingbing, 西島恵子, 大友麻子, 大友麻子, 秦野伸二, 秦野伸二, 木村啓志, 木村啓志. Fabrication and evaluation of microfluidic devices suitable for co-culture of human iPSCs-derived neurons. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
SHIMAKURA Kento, YAMAGUCHI Chisa, YUDAHIRA Haruka, OKA Akira, OTOMO Asako, HADANO Shinji. Monitoring intracellular dynamics of SQSTM1 using a photoconvertible fluorescent protein Dendra2. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
